Citric Acid Potassium Citrate

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Citric Acid Potassium Citrate Brand Names

Cytra K | Polycitra-K | VIRTRATE

What is Citric Acid Potassium Citrate

Citric acid and potassium citrate are orally administered alkalinizing agents. Once absorbed, citrate salts are metabolized to bicarbonates.

In treating metabolic acidosis, the resulting bicarbonates buffer excess hydrogen ion concentrations and raise blood pH.

As a urinary alkalinizer, the generated bicarbonates increase urinary pH by promoting the urinary excretion of free bicarbonate ions.

Citric acid potassium citrate is used to treat some nephrolithiasis conditions by raising urine pH and increasing urinary citrate and potassium concentrations.

Oral administration of potassium citrate reduces the potential crystallization of stone-forming salts in the urine (calcium oxalate, calcium phosphate, and uric acid).

Citrate salts may also be used for the management of renal tubular acidosis (RTA) associated with nephrolithiasis.

Potassium salts such as potassium citrate may be used as a supplement to maintain potassium homeostasis; however, potassium chloride is usually the salt of choice for potassium supplementation.

Indications

  1. metabolic acidosis
  2. nephrolithiasis
  3. nephrolithiasis prevention
  4. renal calculus
  5. renal tubular acidosis (RTA)
  6. urinary alkalinization

For urinary alkalinization for nephrolithiasis prevention (due to nephrolithiasis or renal calculus with uric acid or cystine salts or during use of uricosuric agents); or for the treatment of chronic metabolic acidosis associated with crenal tubular acidosis (RTA) or other renal tubular disorders

Side Effects

  1. abdominal pain
  2. confusion
  3. diarrhea
  4. hyperkalemia
  5. metabolic alkalosis
  6. nausea
  7. paresthesias
  8. tremor
  9. vomiting
  10. weakness

Monitoring Parameters

  • serum creatinine/BUN
  • serum electrolytes

Contraindications

  • adrenal insufficiency
  • anuria
  • atrial fibrillation
  • atrial flutter
  • breast-feeding
  • burns
  • cardiac arrhythmias
  • chronic obstructive pulmonary disease (COPD)
  • dehydration
  • diabetic ketoacidosis
  • diarrhea
  • digitalis toxicity
  • geriatric
  • heart failure
  • hepatic disease
  • hyperkalemia
  • hypertension
  • hypocalcemia
  • metabolic acidosis
  • metabolic alkalosis
  • muscle cramps
  • oliguria
  • peptic ulcer disease
  • pregnancy
  • renal failure
  • renal impairment
  • ventricular arrhythmias
  • ventricular fibrillation
  • ventricular tachycardia

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amphetamines
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Betamethasone
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Colchicine
  • Colchicine; Probenecid
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Deflazacort
  • Desloratadine; Pseudoephedrine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicyclomine
  • Diflunisal
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Donepezil; Memantine
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fexofenadine; Pseudoephedrine
  • Flavoxate
  • Flecainide
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Heparin
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Irbesartan
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lisdexamfetamine
  • Lisinopril
  • Lithium
  • Loperamide
  • Loperamide; Simethicone
  • Loratadine; Pseudoephedrine
  • Losartan
  • Magnesium Salicylate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Memantine
  • Mepenzolate
  • Methamphetamine
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Methylprednisolone
  • Moexipril
  • Mometasone
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol; Valsartan
  • Nonsteroidal antiinflammatory drugs
  • Olmesartan
  • Oxaprozin
  • Oxybutynin
  • Penicillin G
  • Perindopril
  • Perindopril; Amlodipine
  • Piroxicam
  • Prednisolone
  • Prednisone
  • Propantheline
  • Pseudoephedrine
  • Quinapril
  • Quinidine
  • Quinine
  • Ramipril
  • Rofecoxib
  • Sacubitril; Valsartan
  • Salicylates
  • Salsalate
  • Scopolamine
  • Sodium Polystyrene Sulfonate
  • Spironolactone
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulindac
  • Tacrolimus
  • Telmisartan
  • Tolmetin
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamcinolone
  • Triamterene
  • Trihexyphenidyl
  • Trimethoprim
  • Valdecoxib
  • Valsartan

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