Chlordiazepoxide Brand Name– Librium
What is Chlordiazepoxide
Chlordiazepoxide is a long-acting oral and parenteral benzodiazepine used to manage symptoms associated with anxiety disorders.
Chlordiazepoxide also has been used for many years in the management of ethanol withdrawal, but many clinicians now prefer lorazepam because it is shorter acting and has no active metabolites.
Although chlordiazepoxide is used to reduce preoperative anxiety, midazolam is considered the drug of choice by most clinicians because of its rapid onset of action and short duration of effect.
Use of chlordiazepoxide has declined significantly since the release of shorter-acting benzodiazepines.
Chlordiazepoxide was approved by the FDA in 1960.
The parenteral formulation of chlordiazepoxide was discontinued in the U.S.
Indications
- alcohol withdrawal
- anxiety
For treatment of anxiety disorders or for the short-term relief of symptoms of anxiety
Side Effects
- agitation
- agranulocytosis
- amnesia
- anxiety
- ataxia
- confusion
- constipation
- depression
- drowsiness
- dysarthria
- edema
- EEG changes
- elevated hepatic enzymes
- hostility
- irritability
- jaundice
- libido decrease
- libido increase
- memory impairment
- menstrual irregularity
- nausea
- neonatal abstinence syndrome
- neonatal respiratory depression
- physiological dependence
- porphyria
- psychological dependence
- purpura
- rash
- respiratory depression
- syncope
- teratogenesis
- tolerance
- urinary incontinence
- urinary retention
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- benzodiazepine dependence
- benzodiazepine hypersensitivity
- bipolar disorder
- breast-feeding
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- coadministration with other CNS depressants
- coma
- dementia
- depression
- driving or operating machinery
- ethanol ingestion
- ethanol intoxication
- geriatric
- head trauma
- hepatic disease
- infants
- intraarterial administration
- labor
- mania
- myasthenia gravis
- neonates
- neuromuscular disease
- obstetric delivery
- Parkinson’s disease
- porphyria
- pregnancy
- psychosis
- pulmonary disease
- renal failure
- renal impairment
- respiratory depression
- seizure disorder
- seizures
- shock
- sleep apnea
- status epilepticus
- substance abuse
- suicidal ideation
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alfentanil
- Alprazolam
- Amiodarone
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atracurium
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benztropine
- Bosentan
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone; Clonidine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Cisatracurium
- Clarithromycin
- Clemastine
- Clobazam
- Clonidine
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- COMT inhibitors
- Conivaptan
- Cyclizine
- Cyproheptadine
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desflurane
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disulfiram
- Doxacurium
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Esketamine
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etomidate
- Fentanyl
- Flumazenil
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Gabapentin
- General anesthetics
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Idelalisib
- Iloperidone
- Imatinib
- Indinavir
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketamine
- Ketoconazole
- Lasmiditan
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levocetirizine
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Lithium
- Lofexidine
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Meclizine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mestranol; Norethindrone
- Methadone
- Methocarbamol
- Methohexital
- Methscopolamine
- Methyldopa
- Metoclopramide
- Metyrapone
- Metyrosine
- Milnacipran
- Minocycline
- Mirtazapine
- Mitotane
- Mivacurium
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nelfinavir
- Neuromuscular blockers
- Nevirapine
- Nicardipine
- Nitroglycerin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Oxybutynin
- Oxycodone
- Oxymorphone
- Paliperidone
- Pancuronium
- Papaverine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Phenobarbital
- Phenothiazines
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Posaconazole
- Pramipexole
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Pregabalin
- Primidone
- Probenecid
- Procarbazine
- Propofol
- Propoxyphene
- Protease inhibitors
- Quetiapine
- Ramelteon
- Ranolazine
- Rapacuronium
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rocuronium
- Ropinirole
- Rotigotine
- Safinamide
- Saquinavir
- Scopolamine
- Secobarbital
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Sevoflurane
- Sincalide
- Skeletal Muscle Relaxants
- Sodium Oxybate
- St. John’s Wort, Hypericum perforatum
- Succinylcholine
- Sufentanil
- Suvorexant
- Tacrine
- Tapentadol
- Teduglutide
- Telithromycin
- Telotristat Ethyl
- Tetrabenazine
- Thalidomide
- Theophylline, Aminophylline
- Thiopental
- Thiothixene
- Tiagabine
- Tipranavir
- Tizanidine
- Topiramate
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Tricyclic antidepressants
- Trihexyphenidyl
- Trimethobenzamide
- Triprolidine
- Tubocurarine
- Valerian, Valeriana officinalis
- Vecuronium
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Warfarin
- Zafirlukast
- Zaleplon
- Zileuton
- Ziprasidone
- Zolpidem
