Chlordiazepoxide Clidinium

Chlordiazepoxide Clidinium Brand Name– Librax

What is Chlordiazepoxide Clidinium

Chlordiazepoxide and clidinium are a benzodiazepine and an antimuscarinic, respectively, used together in an oral preparation to control emotional and somatic factors in gastrointestinal disorders.

Chlordiazepoxide; clidinium may also be used as adjunctive therapy to treat GI-related problems such as irritable bowel syndrome and peptic ulcer disease.

Chlordiazepoxide clidinium does not aid in the healing of peptic ulcers and other, clinically proven therapies should be used for active ulcer disease.

The use of this combination for the treatment of acute enterocolitis is not recommended as the drug may lead to a reduction in GI motility resulting in retention of the GI toxin.

Doses of each ingredient should be titrated and individualized, especially in the elderly.

Chlordiazepoxide clidinium was approved by the FDA in the early 1960’s.

Indications

  1. enterocolitis
  2. gastric ulcer
  3. irritable bowel syndrome

To control emotional and somatic factors in gastrointestinal disorders and for the adjunctive treatment of peptic ulcer disease (duodenal ulcer or gastric ulcer) or the symptomatic treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis

Side Effects

  1. agitation
  2. agranulocytosis
  3. anaphylactoid reactions
  4. anhidrosis
  5. ataxia
  6. blurred vision
  7. confusion
  8. constipation
  9. cycloplegia
  10. dizziness
  11. drowsiness
  12. dysgeusia
  13. edema
  14. headache
  15. hostility
  16. hyperthermia
  17. impotence (erectile dysfunction)
  18. insomnia
  19. irritability
  20. jaundice
  21. libido decrease
  22. libido increase
  23. menstrual irregularity
  24. mydriasis
  25. nausea
  26. ocular hypertension
  27. palpitations
  28. physiological dependence
  29. psychosis
  30. sinus tachycardia
  31. syncope
  32. teratogenesis
  33. thrombotic thrombocytopenic purpura (TTP)
  34. tolerance
  35. tremor
  36. urinary retention
  37. urticaria
  38. vomiting
  39. weakness
  40. withdrawal
  41. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • abrupt discontinuation
  • alcoholism
  • ambient temperature increase
  • anticholinergic medications
  • autonomic neuropathy
  • benzodiazepine dependence
  • benzodiazepine hypersensitivity
  • bladder obstruction
  • breast-feeding
  • cardiac arrhythmias
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • CNS depression
  • coadministration with other CNS depressants
  • coronary artery disease
  • dementia
  • depression
  • diarrhea
  • driving or operating machinery
  • esophagitis
  • ethanol ingestion
  • ethanol intoxication
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI obstruction
  • heart failure
  • hepatic disease
  • hiatal hernia
  • hyperthyroidism
  • ileus
  • labor
  • myasthenia gravis
  • obstetric delivery
  • Parkinson’s disease
  • porphyria
  • pregnancy
  • prostatic hypertrophy
  • pulmonary disease
  • renal failure
  • renal impairment
  • respiratory depression
  • sleep apnea
  • substance abuse
  • suicidal ideation
  • tachycardia
  • toxic megacolon
  • ulcerative colitis
  • urinary retention

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aclidinium
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Alosetron
  • Alprazolam
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Ambenonium Chloride
  • Amiodarone
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Antacids
  • Apomorphine
  • Apraclonidine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atracurium
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benztropine
  • Bosentan
  • Botulinum Toxins
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Cannabidiol
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Cholinergic agonists
  • Cimetidine
  • Ciprofloxacin
  • Cisapride
  • Cisatracurium
  • Clarithromycin
  • Clemastine
  • Clobazam
  • Clonidine
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Conivaptan
  • Crofelemer
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desflurane
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dicyclomine
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Donepezil
  • Donepezil; Memantine
  • Doxacurium
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Eluxadoline
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enflurane
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Etomidate
  • Ezogabine
  • Fentanyl
  • Flumazenil
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluvoxamine
  • food
  • Fosamprenavir
  • Fosphenytoin
  • Fospropofol
  • Gabapentin
  • Galantamine
  • General anesthetics
  • Glucagon
  • Glycopyrronium
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Guanfacine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Indinavir
  • Ipratropium
  • Isavuconazonium
  • Isoflurane
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketamine
  • Ketoconazole
  • Lasmiditan
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Levocetirizine
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Linaclotide
  • Lithium
  • Lofexidine
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Loxapine
  • Lubiprostone
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Hydroxide
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Memantine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mestranol; Norethindrone
  • Methacholine
  • Methadone
  • Methocarbamol
  • Methohexital
  • Methscopolamine
  • Methyldopa
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Milnacipran
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Mivacurium
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nelfinavir
  • Neuromuscular blockers
  • Nevirapine
  • Nicardipine
  • Nitrofurantoin
  • Nitroglycerin
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oritavancin
  • Orphenadrine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pancuronium
  • Papaverine
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimozide
  • Posaconazole
  • Potassium
  • Pramipexole
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Pregabalin
  • Primidone
  • Probenecid
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Protease inhibitors
  • Proton pump inhibitors
  • Quetiapine
  • Quinidine
  • Ramelteon
  • Ranolazine
  • Rapacuronium
  • Rasagiline
  • Remifentanil
  • Revefenacin
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Risperidone
  • Ritonavir
  • Rivastigmine
  • Rocuronium
  • Ropinirole
  • Rotigotine
  • Safinamide
  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Secretin
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Sevoflurane
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Bicarbonate
  • Sodium Oxybate
  • Solifenacin
  • St. John’s Wort, Hypericum perforatum
  • Succinylcholine
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tapentadol
  • Teduglutide
  • Tegaserod
  • Telithromycin
  • Telotristat Ethyl
  • Tetrabenazine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tiagabine
  • Tiotropium
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tizanidine
  • Tolterodine
  • Topiramate
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Triprolidine
  • Trospium
  • Tubocurarine
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Vecuronium
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Warfarin
  • Zafirlukast
  • Zaleplon
  • Zileuton
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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