Chlordiazepoxide Clidinium Brand Name– Librax
What is Chlordiazepoxide Clidinium
Chlordiazepoxide and clidinium are a benzodiazepine and an antimuscarinic, respectively, used together in an oral preparation to control emotional and somatic factors in gastrointestinal disorders.
Chlordiazepoxide; clidinium may also be used as adjunctive therapy to treat GI-related problems such as irritable bowel syndrome and peptic ulcer disease.
Chlordiazepoxide clidinium does not aid in the healing of peptic ulcers and other, clinically proven therapies should be used for active ulcer disease.
The use of this combination for the treatment of acute enterocolitis is not recommended as the drug may lead to a reduction in GI motility resulting in retention of the GI toxin.
Doses of each ingredient should be titrated and individualized, especially in the elderly.
Chlordiazepoxide clidinium was approved by the FDA in the early 1960’s.
Indications
- enterocolitis
- gastric ulcer
- irritable bowel syndrome
To control emotional and somatic factors in gastrointestinal disorders and for the adjunctive treatment of peptic ulcer disease (duodenal ulcer or gastric ulcer) or the symptomatic treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis
Side Effects
- agitation
- agranulocytosis
- anaphylactoid reactions
- anhidrosis
- ataxia
- blurred vision
- confusion
- constipation
- cycloplegia
- dizziness
- drowsiness
- dysgeusia
- edema
- headache
- hostility
- hyperthermia
- impotence (erectile dysfunction)
- insomnia
- irritability
- jaundice
- libido decrease
- libido increase
- menstrual irregularity
- mydriasis
- nausea
- ocular hypertension
- palpitations
- physiological dependence
- psychosis
- sinus tachycardia
- syncope
- teratogenesis
- thrombotic thrombocytopenic purpura (TTP)
- tolerance
- tremor
- urinary retention
- urticaria
- vomiting
- weakness
- withdrawal
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- alcoholism
- ambient temperature increase
- anticholinergic medications
- autonomic neuropathy
- benzodiazepine dependence
- benzodiazepine hypersensitivity
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- CNS depression
- coadministration with other CNS depressants
- coronary artery disease
- dementia
- depression
- diarrhea
- driving or operating machinery
- esophagitis
- ethanol ingestion
- ethanol intoxication
- gastroesophageal reflux disease (GERD)
- geriatric
- GI obstruction
- heart failure
- hepatic disease
- hiatal hernia
- hyperthyroidism
- ileus
- labor
- myasthenia gravis
- obstetric delivery
- Parkinson’s disease
- porphyria
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- renal failure
- renal impairment
- respiratory depression
- sleep apnea
- substance abuse
- suicidal ideation
- tachycardia
- toxic megacolon
- ulcerative colitis
- urinary retention
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aclidinium
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Alosetron
- Alprazolam
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amantadine
- Ambenonium Chloride
- Amiodarone
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Antacids
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atracurium
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benztropine
- Bosentan
- Botulinum Toxins
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Cholinergic agonists
- Cimetidine
- Ciprofloxacin
- Cisapride
- Cisatracurium
- Clarithromycin
- Clemastine
- Clobazam
- Clonidine
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- COMT inhibitors
- Conivaptan
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desflurane
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dicyclomine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Disulfiram
- Donepezil
- Donepezil; Memantine
- Doxacurium
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enflurane
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esketamine
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etomidate
- Ezogabine
- Fentanyl
- Flumazenil
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Umeclidinium; Vilanterol
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Gabapentin
- Galantamine
- General anesthetics
- Glucagon
- Glycopyrronium
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Idelalisib
- Iloperidone
- Imatinib
- Indinavir
- Ipratropium
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketamine
- Ketoconazole
- Lasmiditan
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levocetirizine
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Linaclotide
- Lithium
- Lofexidine
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loxapine
- Lubiprostone
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Magnesium Hydroxide
- Magnesium Salts
- Maprotiline
- Meclizine
- Memantine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mestranol; Norethindrone
- Methacholine
- Methadone
- Methocarbamol
- Methohexital
- Methscopolamine
- Methyldopa
- Metoclopramide
- Metyrapone
- Metyrosine
- Milnacipran
- Minocycline
- Mirtazapine
- Mitotane
- Mivacurium
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nelfinavir
- Neuromuscular blockers
- Nevirapine
- Nicardipine
- Nitrofurantoin
- Nitroglycerin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Orphenadrine
- Oxybutynin
- Oxycodone
- Oxymorphone
- Paliperidone
- Pancuronium
- Papaverine
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Posaconazole
- Potassium
- Pramipexole
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Pregabalin
- Primidone
- Probenecid
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Protease inhibitors
- Proton pump inhibitors
- Quetiapine
- Quinidine
- Ramelteon
- Ranolazine
- Rapacuronium
- Rasagiline
- Remifentanil
- Revefenacin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rivastigmine
- Rocuronium
- Ropinirole
- Rotigotine
- Safinamide
- Saquinavir
- Scopolamine
- Secobarbital
- Secretin
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Sevoflurane
- Sincalide
- Skeletal Muscle Relaxants
- Sodium Bicarbonate
- Sodium Oxybate
- Solifenacin
- St. John’s Wort, Hypericum perforatum
- Succinylcholine
- Sufentanil
- Suvorexant
- Tacrine
- Tapentadol
- Teduglutide
- Tegaserod
- Telithromycin
- Telotristat Ethyl
- Tetrabenazine
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiopental
- Thioridazine
- Thiothixene
- Tiagabine
- Tiotropium
- Tiotropium; Olodaterol
- Tipranavir
- Tizanidine
- Tolterodine
- Topiramate
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Triprolidine
- Trospium
- Tubocurarine
- Umeclidinium
- Umeclidinium; Vilanterol
- Valerian, Valeriana officinalis
- Vecuronium
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Warfarin
- Zafirlukast
- Zaleplon
- Zileuton
- Ziprasidone
- Zolpidem
- Zonisamide