Cetirizine

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Cetirizine Brand Names

All Day Allergy | All Day Allergy Children’s | Allergy Relief | PediaCare Children’s Allergy | Quzyttir | ZERVIATE | Zyrtec | Zyrtec Children’s | Zyrtec Children’s Allergy | Zyrtec Children’s Hives | Zyrtec Hives Relief | Zyrtec Liquid Gel | Zyrtec Pre-Filled Spoons

What is Cetirizine

Cetirizine is the active metabolite of hydroxyzine, a piperazine H1-receptor antagonist (H1-blocker). Cetirizine differs from the parent compound by having greater affinity for the H1-receptor.

Cetirizine is commercially available as oral, ophthalmic, and injectable formulations. The ophthalmic solution is indicated to treat ocular pruritus associated with allergic conjunctivitis.

Oral cetirizine is approved for allergic rhinitis and chronic idiopathic urticaria.

In addition, oral cetirizine has been used off-label in pediatric patients for symptomatic treatment of atopic dermatitis.

Cetirizine intravenous injection is used to treat acute urticaria in adults and children 6 months of age and older.

At recommended doses, cetirizine may cause a higher incidence of somnolence than the non-sedating antihistamines (e.g., loratadine), although to a much lesser degree than first-generation (sedating) antihistamines.

Like loratadine, the cardiovascular safety of cetirizine has been demonstrated in drug-interaction studies, elevated-dose studies, and clinical trials.

Indications

  1. acute urticaria
  2. allergic conjunctivitis
  3. allergic rhinitis
  4. atopic dermatitis
  5. chronic idiopathic urticaria
  6. ocular pruritus
  7. perennial allergies
  8. pruritus
  9. seasonal allergies

For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. agitation
  4. amnesia
  5. anaphylactoid reactions
  6. angioedema
  7. anorexia
  8. anxiety
  9. appetite stimulation
  10. arthralgia
  11. arthropathy
  12. asthenia
  13. ataxia
  14. atopic dermatitis
  15. back pain
  16. blurred vision
  17. bronchospasm
  18. chest pain (unspecified)
  19. cholestasis
  20. conjunctival hyperemia
  21. conjunctivitis
  22. constipation
  23. cough
  24. cystitis
  25. dehydration
  26. dental caries
  27. depression
  28. diabetes mellitus
  29. diarrhea
  30. dizziness
  31. drowsiness
  32. dysgeusia
  33. dyskinesia
  34. dysmenorrhea
  35. dyspepsia
  36. dysphonia
  37. dyspnea
  38. dysuria
  39. edema
  40. elevated hepatic enzymes
  41. emotional lability
  42. epistaxis
  43. eructation
  44. euphoria
  45. fatigue
  46. fetal death
  47. fever
  48. flatulence
  49. flushing
  50. furunculosis
  51. gastritis
  52. glomerulonephritis
  53. hallucinations
  54. headache
  55. hearing loss
  56. heart failure
  57. hematuria
  58. hemolytic anemia
  59. hemorrhoids
  60. hepatitis
  61. hot flashes
  62. hyperbilirubinemia
  63. hyperesthesia
  64. hyperhidrosis
  65. hyperkeratosis
  66. hyperkinesis
  67. hypersalivation
  68. hypertension
  69. hypertonia
  70. hypertrichosis
  71. hyperventilation
  72. hypoesthesia
  73. hypotension
  74. increased urinary frequency
  75. insomnia
  76. leukorrhea
  77. libido decrease
  78. lymphadenopathy
  79. maculopapular rash
  80. malaise
  81. mastalgia
  82. melena
  83. menorrhagia
  84. menstrual irregularity
  85. migraine
  86. muscle cramps
  87. myalgia
  88. myasthenia
  89. myelitis
  90. myoclonia
  91. nausea
  92. nightmares
  93. ocular hemorrhage
  94. ocular hypertension
  95. ocular pain
  96. otalgia
  97. pallor
  98. palpitations
  99. paresthesias
  100. parosmia
  101. peripheral edema
  102. pharyngitis
  103. photosensitivity
  104. polydipsia
  105. polyuria
  106. pruritus
  107. ptosis
  108. purpura
  109. rash
  110. rhinitis
  111. seborrhea
  112. seizures
  113. sinus tachycardia
  114. sinusitis
  115. stomatitis
  116. suicidal ideation
  117. syncope
  118. thrombocytopenia
  119. tinnitus
  120. tongue discoloration
  121. tremor
  122. urinary incontinence
  123. urinary retention
  124. urticaria
  125. vaginitis
  126. vertigo
  127. visual impairment
  128. vomiting
  129. weight gain
  130. xerophthalmia
  131. xerosis
  132. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • coadministration with other CNS depressants
  • contact lenses
  • driving or operating machinery
  • ethanol ingestion
  • geriatric
  • hepatic disease
  • hydroxyzine hypersensitivity
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Alfentanil
  • Alprazolam
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Anticholinergics
  • Apomorphine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Brexpiprazole
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Cenobamate
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexmedetomidine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dronabinol
  • Droperidol
  • Enflurane
  • Entacapone
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Fospropofol
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Halothane
  • Heparin
  • Heterocyclic antidepressants
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Isocarboxazid
  • Isoflurane
  • Ketamine
  • Levodopa
  • Levorphanol
  • Lofexidine
  • Lopinavir; Ritonavir
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Maprotiline
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methohexital
  • Methyldopa
  • Midazolam
  • Mirtazapine
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Opiate Agonists
  • Orphenadrine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Phenelzine
  • Phenobarbital
  • Pimavanserin
  • Pimozide
  • Pramipexole
  • Pregabalin
  • Primidone
  • Propofol
  • Propoxyphene
  • Quazepam
  • Quetiapine
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Ritonavir
  • Ropinirole
  • Rotigotine
  • Safinamide
  • Secobarbital
  • Sedating H1-blockers
  • Selegiline
  • Sevoflurane
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Oxybate
  • Sufentanil
  • Suvorexant
  • Tapentadol
  • Tasimelteon
  • Temazepam
  • Tetrabenazine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiopental
  • Thiothixene
  • Tolcapone
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trospium
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Zaleplon
  • Ziprasidone
  • Zolpidem

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