Cetirizine

Cetirizine Brand Names

All Day Allergy | All Day Allergy Children’s | Allergy Relief | PediaCare Children’s Allergy | Quzyttir | ZERVIATE | Zyrtec | Zyrtec Children’s | Zyrtec Children’s Allergy | Zyrtec Children’s Hives | Zyrtec Hives Relief | Zyrtec Liquid Gel | Zyrtec Pre-Filled Spoons

What is Cetirizine

Cetirizine is the active metabolite of hydroxyzine, a piperazine H1-receptor antagonist (H1-blocker). Cetirizine differs from the parent compound by having greater affinity for the H1-receptor.

Cetirizine is commercially available as oral, ophthalmic, and injectable formulations. The ophthalmic solution is indicated to treat ocular pruritus associated with allergic conjunctivitis.

Oral cetirizine is approved for allergic rhinitis and chronic idiopathic urticaria.

In addition, oral cetirizine has been used off-label in pediatric patients for symptomatic treatment of atopic dermatitis.

Cetirizine intravenous injection is used to treat acute urticaria in adults and children 6 months of age and older.

At recommended doses, cetirizine may cause a higher incidence of somnolence than the non-sedating antihistamines (e.g., loratadine), although to a much lesser degree than first-generation (sedating) antihistamines.

Like loratadine, the cardiovascular safety of cetirizine has been demonstrated in drug-interaction studies, elevated-dose studies, and clinical trials.

Indications

1. acute urticaria
2. allergic conjunctivitis
3. allergic rhinitis
4. atopic dermatitis
5. chronic idiopathic urticaria
6. ocular pruritus
7. perennial allergies
8. pruritus
9. seasonal allergies

For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis

Side Effects

1. abdominal pain
2. acne vulgaris
3. agitation
4. amnesia
5. anaphylactoid reactions
6. angioedema
7. anorexia
8. anxiety
9. appetite stimulation
10. arthralgia
11. arthropathy
12. asthenia
13. ataxia
14. atopic dermatitis
15. back pain
16. blurred vision
17. bronchospasm
18. chest pain (unspecified)
19. cholestasis
20. conjunctival hyperemia
21. conjunctivitis
22. constipation
23. cough
24. cystitis
25. dehydration
26. dental caries
27. depression
28. diabetes mellitus
29. diarrhea
30. dizziness
31. drowsiness
32. dysgeusia
33. dyskinesia
34. dysmenorrhea
35. dyspepsia
36. dysphonia
37. dyspnea
38. dysuria
39. edema
40. elevated hepatic enzymes
41. emotional lability
42. epistaxis
43. eructation
44. euphoria
45. fatigue
46. fetal death
47. fever
48. flatulence
49. flushing
50. furunculosis
51. gastritis
52. glomerulonephritis
53. hallucinations
54. headache
55. hearing loss
56. heart failure
57. hematuria
58. hemolytic anemia
59. hemorrhoids
60. hepatitis
61. hot flashes
62. hyperbilirubinemia
63. hyperesthesia
64. hyperhidrosis
65. hyperkeratosis
66. hyperkinesis
67. hypersalivation
68. hypertension
69. hypertonia
70. hypertrichosis
71. hyperventilation
72. hypoesthesia
73. hypotension
74. increased urinary frequency
75. insomnia
76. leukorrhea
77. libido decrease
78. lymphadenopathy
79. maculopapular rash
80. malaise
81. mastalgia
82. melena
83. menorrhagia
84. menstrual irregularity
85. migraine
86. muscle cramps
87. myalgia
88. myasthenia
89. myelitis
90. myoclonia
91. nausea
92. nightmares
93. ocular hemorrhage
94. ocular hypertension
95. ocular pain
96. otalgia
97. pallor
98. palpitations
99. paresthesias
100. parosmia
101. peripheral edema
102. pharyngitis
103. photosensitivity
104. polydipsia
105. polyuria
106. pruritus
107. ptosis
108. purpura
109. rash
110. rhinitis
111. seborrhea
112. seizures
113. sinus tachycardia
114. sinusitis
115. stomatitis
116. suicidal ideation
117. syncope
118. thrombocytopenia
119. tinnitus
120. tongue discoloration
121. tremor
122. urinary incontinence
123. urinary retention
124. urticaria
125. vaginitis
126. vertigo
127. visual impairment
128. vomiting
129. weight gain
130. xerophthalmia
131. xerosis
132. xerostomia

Monitoring Parameters

• serum creatinine/BUN

Contraindications

• breast-feeding
• coadministration with other CNS depressants
• contact lenses
• driving or operating machinery
• ethanol ingestion
• geriatric
• hepatic disease
• hydroxyzine hypersensitivity
• pregnancy
• renal failure
• renal impairment

Interactions

• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Codeine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Alfentanil
• Alprazolam
• Amitriptyline; Chlordiazepoxide
• Amobarbital
• Amoxapine
• Anticholinergics
• Apomorphine
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• atypical antipsychotic
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Brexpiprazole
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Butabarbital
• Butorphanol
• Cannabidiol
• Capsaicin; Metaxalone
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Cariprazine
• Carisoprodol
• Cenobamate
• Chloral Hydrate
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Clonazepam
• Clonidine
• Clorazepate
• Clozapine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Cyclobenzaprine
• Dantrolene
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Desloratadine
• Desloratadine; Pseudoephedrine
• Deutetrabenazine
• Dexmedetomidine
• Diazepam
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Dronabinol
• Droperidol
• Enflurane
• Entacapone
• Esketamine
• Estazolam
• Eszopiclone
• Ethanol
• Etomidate
• Fentanyl
• Flibanserin
• Fluoxetine; Olanzapine
• Flurazepam
• Fospropofol
• Gabapentin
• General anesthetics
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanfacine
• Haloperidol
• Halothane
• Heparin
• Heterocyclic antidepressants
• Homatropine; Hydrocodone
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Ibuprofen; Oxycodone
• Iloperidone
• Isocarboxazid
• Isoflurane
• Ketamine
• Levodopa
• Levorphanol
• Lofexidine
• Lopinavir; Ritonavir
• Loratadine
• Loratadine; Pseudoephedrine
• Lorazepam
• Loxapine
• Lumateperone
• Lurasidone
• Maprotiline
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaxalone
• Methadone
• Methohexital
• Methyldopa
• Midazolam
• Mirtazapine
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nalbuphine
• Nefazodone
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Opiate Agonists
• Orphenadrine
• Oxazepam
• Oxycodone
• Oxymorphone
• Paliperidone
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Phenelzine
• Phenobarbital
• Pimavanserin
• Pimozide
• Pramipexole
• Pregabalin
• Primidone
• Propofol
• Propoxyphene
• Quazepam
• Quetiapine
• Ramelteon
• Rasagiline
• Remifentanil
• Risperidone
• Ritonavir
• Ropinirole
• Rotigotine
• Safinamide
• Secobarbital
• Sedating H1-blockers
• Selegiline
• Sevoflurane
• Sincalide
• Skeletal Muscle Relaxants
• Sodium Oxybate
• Sufentanil
• Suvorexant
• Tapentadol
• Tasimelteon
• Temazepam
• Tetrabenazine
• Thalidomide
• Theophylline, Aminophylline
• Thiopental
• Thiothixene
• Tolcapone
• Tramadol
• Tranylcypromine
• Trazodone
• Triazolam
• Tricyclic antidepressants
• Trospium
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Zaleplon
• Ziprasidone
• Zolpidem