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Azelastine Brand Names
Astelin | Astepro | Optivar
What is Azelastine
Azelastine is a phthalazinone second-generation antihistamine (H1-blocker) and an inhibitor of mast cell histamine release.
It is used topically in adult and pediatric patients for the management of symptoms associated with allergic or vasomotor rhinitis and allergic conjunctivitis.
The FDA approved the first azelastine nasal spray in November 1996; several different nasal formulations have been approved since that time. An ophthalmic preparation was FDA-approved in May 2000.
The Astepro nasal spray formulation is approved for use in infants as young as 6 months of age for certain indications.
Indications
- allergic conjunctivitis
- allergic rhinitis
- ocular pruritus
- perennial allergies
- seasonal allergies
- vasomotor rhinitis
For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis
Side Effects
- abdominal pain
- amenorrhea
- anaphylactoid reactions
- anxiety
- appetite stimulation
- atrial fibrillation
- back pain
- blurred vision
- bronchospasm
- chest pain (unspecified)
- confusion
- conjunctivitis
- constipation
- contact dermatitis
- cough
- depression
- diarrhea
- dizziness
- drowsiness
- dysesthesia
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- epistaxis
- fatigue
- fever
- flushing
- furunculosis
- glossitis
- headache
- hematuria
- hyperkinesis
- hypertension
- hypoesthesia
- increased urinary frequency
- infection
- insomnia
- laryngitis
- malaise
- myalgia
- nasal congestion
- nasal dryness
- nasal irritation
- nausea
- ocular irritation
- ocular pain
- palpitations
- paresthesias
- pharyngitis
- pruritus
- rash
- rhinalgia
- rhinitis
- sinus tachycardia
- sinusitis
- sneezing
- stomatitis
- throat irritation
- tolerance
- urinary retention
- vertigo
- vomiting
- weight gain
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- contact lenses
- driving or operating machinery
- pregnancy
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Amoxapine
- Anxiolytics; Sedatives; and Hypnotics
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Baclofen
- Barbiturates
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buspirone
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cimetidine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclobenzaprine
- Dantrolene
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Droperidol
- Entacapone
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esketamine
- Ethanol
- Fentanyl
- Fluphenazine
- Gabapentin
- General anesthetics
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Ketoconazole
- Levomethadyl
- Levorphanol
- Lofexidine
- Lumateperone
- Maprotiline
- Meperidine
- Meperidine; Promethazine
- Mesoridazine
- Metaxalone
- Methadone
- Methocarbamol
- Mirtazapine
- Morphine
- Morphine; Naltrexone
- Nalbuphine
- Nefazodone
- Orphenadrine
- Oxycodone
- Oxymorphone
- Pentazocine
- Pentazocine; Naloxone
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pitolisant
- Pramipexole
- Pregabalin
- Prochlorperazine
- Promethazine
- Propoxyphene
- Remifentanil
- Ropinirole
- Sedating H1-blockers
- Skeletal Muscle Relaxants
- Sufentanil
- Tapentadol
- Thalidomide
- Theophylline, Aminophylline
- Thiethylperazine
- Thioridazine
- Thiothixene
- Tizanidine
- Tolcapone
- Tramadol
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine