Azelastine

Azelastine Brand Names

Astelin | Astepro | Optivar

What is Azelastine

Azelastine is a phthalazinone second-generation antihistamine (H1-blocker) and an inhibitor of mast cell histamine release.

It is used topically in adult and pediatric patients for the management of symptoms associated with allergic or vasomotor rhinitis and allergic conjunctivitis.

The FDA approved the first azelastine nasal spray in November 1996; several different nasal formulations have been approved since that time. An ophthalmic preparation was FDA-approved in May 2000.

The Astepro nasal spray formulation is approved for use in infants as young as 6 months of age for certain indications.

Indications

  1. allergic conjunctivitis
  2. allergic rhinitis
  3. ocular pruritus
  4. perennial allergies
  5. seasonal allergies
  6. vasomotor rhinitis

For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis

Side Effects

  1. abdominal pain
  2. amenorrhea
  3. anaphylactoid reactions
  4. anxiety
  5. appetite stimulation
  6. atrial fibrillation
  7. back pain
  8. blurred vision
  9. bronchospasm
  10. chest pain (unspecified)
  11. confusion
  12. conjunctivitis
  13. constipation
  14. contact dermatitis
  15. cough
  16. depression
  17. diarrhea
  18. dizziness
  19. drowsiness
  20. dysesthesia
  21. dysgeusia
  22. dyspnea
  23. elevated hepatic enzymes
  24. epistaxis
  25. fatigue
  26. fever
  27. flushing
  28. furunculosis
  29. glossitis
  30. headache
  31. hematuria
  32. hyperkinesis
  33. hypertension
  34. hypoesthesia
  35. increased urinary frequency
  36. infection
  37. insomnia
  38. laryngitis
  39. malaise
  40. myalgia
  41. nasal congestion
  42. nasal dryness
  43. nasal irritation
  44. nausea
  45. ocular irritation
  46. ocular pain
  47. palpitations
  48. paresthesias
  49. pharyngitis
  50. pruritus
  51. rash
  52. rhinalgia
  53. rhinitis
  54. sinus tachycardia
  55. sinusitis
  56. sneezing
  57. stomatitis
  58. throat irritation
  59. tolerance
  60. urinary retention
  61. vertigo
  62. vomiting
  63. weight gain
  64. xerophthalmia
  65. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • contact lenses
  • driving or operating machinery
  • pregnancy

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Alfentanil
  • Amoxapine
  • Anxiolytics; Sedatives; and Hypnotics
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Baclofen
  • Barbiturates
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buspirone
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorzoxazone
  • Cimetidine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Deutetrabenazine
  • Dextromethorphan; Promethazine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Droperidol
  • Entacapone
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Ethanol
  • Fentanyl
  • Fluphenazine
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Ketoconazole
  • Levomethadyl
  • Levorphanol
  • Lofexidine
  • Lumateperone
  • Maprotiline
  • Meperidine
  • Meperidine; Promethazine
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methocarbamol
  • Mirtazapine
  • Morphine
  • Morphine; Naltrexone
  • Nalbuphine
  • Nefazodone
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Pentazocine
  • Pentazocine; Naloxone
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenylephrine; Promethazine
  • Pitolisant
  • Pramipexole
  • Pregabalin
  • Prochlorperazine
  • Promethazine
  • Propoxyphene
  • Remifentanil
  • Ropinirole
  • Sedating H1-blockers
  • Skeletal Muscle Relaxants
  • Sufentanil
  • Tapentadol
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiethylperazine
  • Thioridazine
  • Thiothixene
  • Tizanidine
  • Tolcapone
  • Tramadol
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
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