Cetirizine Pseudoephedrine

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Cetirizine Pseudoephedrine Brand Names

All Day Allergy-D | Allergy Relief Nasal Decongestant 12 Hour | Zyrtec-D | Zyrtec-D Allergy + Congestion

What is Cetirizine Pseudoephedrine

Cetirizine and pseudoephedrine extended-release are used together in an oral preparation for the relief of nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis.

Specifically, the combination may relieve nasal congestion, rhinorrhea, sneezing, itching of the nose or throat, and itchy, watery eyes.

Cetirizine is the active metabolite of hydroxyzine, a piperazine H1-receptor antagonist, but has negligible anticholinergic activity.

Cetirizine has not been shown to prolong the QTc interval. Pseudoephedrine is a sympathomimetic agent that stimulates alpha-1-adrenergic receptors in vascular smooth muscle. This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and increase in nasal airway patency.

Pseudoephedrine is commonly diverted for use as a substrate for the illegal synthesis of amphetamine and methamphetamine.

The Combat Methamphetamine Epidemic Act of 2005 governs the sale and purchase of all OTC products containing pseudoephedrine, ephedrine, or phenylpropanolamine in the US.

Retailers must keep products in locked cabinets or behind counters prior to purchase, enter individual product purchases and amounts into a log and maintain it for at least 2 years following each sale, require photo identification and verify customer-required entries into the log, and ensure daily and monthly allowable limits on purchases are not exceeded (review Patriot Act Title VII for more information on legal requirements).

Cetirizine pseudoephedrine (Zyrtec-D®) was approved by the FDA in August 2001 as a prescription-only product.

In November 2007, the FDA approved Zyrtec-D® for use as an OTC medication, in adults and children 12 years of age and older, for hay fever or other upper respiratory allergies.

Indications

  • allergic rhinitis
  • nasal congestion

For the treatment of seasonal or perennial allergic rhinitis and accompanying nasal congestion and symptoms (e.g., sneezing; rhinorrhea; itchy, watery eyes; itchy throat or nose)

Side Effects

  1. anaphylactic shock
  2. anaphylactoid reactions
  3. angina
  4. anorexia
  5. anxiety
  6. arrhythmia exacerbation
  7. colitis
  8. contact dermatitis
  9. dizziness
  10. drowsiness
  11. dysuria
  12. elevated hepatic enzymes
  13. fatigue
  14. hallucinations
  15. hepatitis
  16. hyperbilirubinemia
  17. hypertension
  18. insomnia
  19. myocardial infarction
  20. nausea
  21. ocular hypertension
  22. palpitations
  23. photophobia
  24. premature ventricular contractions (PVCs)
  25. psychosis
  26. rash
  27. seizures
  28. sinus tachycardia
  29. stroke
  30. supraventricular tachycardia (SVT)
  31. vomiting
  32. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • acute myocardial infarction
  • angina
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • closed-angle glaucoma
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • ethanol intoxication
  • geriatric
  • GI obstruction
  • heart failure
  • hepatic disease
  • hydroxyzine hypersensitivity
  • hypertension
  • hyperthyroidism
  • increased intraocular pressure
  • infants
  • MAOI therapy
  • peptic ulcer disease
  • pregnancy
  • renal failure
  • renal impairment
  • tachycardia
  • urinary retention

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Aclidinium; Formoterol
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amobarbital
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Apomorphine
  • Arformoterol
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Beta-blockers
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brexpiprazole
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide; Formoterol
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Cardiac glycosides
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Clevidipine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Diazepam
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dopamine
  • Dorzolamide; Timolol
  • Dronabinol
  • Droperidol
  • Droxidopa
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esketamine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Etomidate
  • Exenatide
  • Felodipine
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Furosemide
  • Gabapentin
  • General anesthetics
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Guanfacine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Heterocyclic antidepressants
  • Homatropine; Hydrocodone
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Ketamine
  • Labetalol
  • Lemborexant
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lisinopril
  • Lixisenatide
  • Lofexidine
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Macitentan
  • Maprotiline
  • Mecamylamine
  • Meglitinides
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaproterenol
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methazolamide
  • Methohexital
  • Methyclothiazide
  • Methyldopa
  • Methylergonovine
  • Methysergide
  • Metolazone
  • Metoprolol
  • Midazolam
  • Midodrine
  • Miglitol
  • Mirtazapine
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nalbuphine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Norepinephrine
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Opiate Agonists
  • Orphenadrine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenobarbital
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pimavanserin
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Pregabalin
  • Primidone
  • Procarbazine
  • Propofol
  • Propoxyphene
  • Propranolol
  • Quazepam
  • Quetiapine
  • Quinapril
  • Racepinephrine
  • Ramelteon
  • Ramipril
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Riociguat
  • Risperidone
  • Ritonavir
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Safinamide
  • Salmeterol
  • Secobarbital
  • Sedating H1-blockers
  • Selegiline
  • Selexipag
  • Semaglutide
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Oxybate
  • Solriamfetol
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfonylureas
  • Suvorexant
  • Tapentadol
  • Tasimelteon
  • Temazepam
  • Terbutaline
  • Tetrabenazine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Thyroid hormones
  • Timolol
  • Tolcapone
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triazolam
  • Tricyclic antidepressants
  • Trospium
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vasodilators
  • Vasopressors
  • Verapamil
  • Yohimbine
  • Zaleplon
  • Ziprasidone
  • Zolpidem

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