Cetrorelix Brand Name– Cetrotide
What is Cetrorelix
Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonist activity similar to ganirelix.
The drug is used to inhibit premature leuteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation followed by insemination or assisted reproductive technology (ART) procedures; cetrorelix has also been used off-label for the treatment of endometriosis and benign prostatic hyperplasia (BPH).
Some data indicate that cetrorelix may also be effective in the treatment of uterine leiomyomata, ovarian cancer, and prostate cancer.
When used in infertility, the main advantage of GnRH antagonists versus GnRH agonists (e.g., leuprolide) is a reduction in the required fertility therapy cycle from several weeks (i.e., 3 weeks) to several days.
Secondarily, the onset of GnRH antagonists occurs rapidly after drug initiation, and the effects reverse rapidly, allowing pituitary function to return to baseline within 1—4 days after drug discontinuation.
Thus, pituitary and hormonal release is essentially normalized at the time of embryo transfer or implantation.
It was theorized that these properties would improve embryo viability and pregnancy success rates; however, results from meta-analyses comparing GnRH antagonists to GnRH agonists do not support this theory.
FDA approval for cetrorelix was granted in August 2000.
- benign prostatic hyperplasia (BPH)
For inhibiting premature leuteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation and subsequent in vitro fertilization (IVF) or other assisted reproductive technology (ART) for the treatment of infertility
- abdominal pain
- anaphylactoid reactions
- antibody formation
- elevated hepatic enzymes
- fetal death
- hot flashes
- injection site reaction
- menstrual irregularity
- ovarian enlargement
- ovarian hyperstimulation syndrome (OHSS)
- pelvic pain
- pelvic exam
- pelvic ultrasound
- serum estradiol concentrations
- serum gonadotropin concentrations
- hepatic disease
- mannitol hypersensitivity
- ovarian cyst
- ovarian failure
- polycystic ovary syndrome
- renal failure
- renal impairment
- tobacco smoking
- atypical antipsychotic
- Fluoxetine; Olanzapine
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)