Cenobamate Brand Name– XCOPRI
What is Cenobamate
Cenobamate is an oral antiepileptic drug indicated for partial-onset seizures in adults.
In placebo-controlled clinical trials, cenobamate significantly decreased seizure frequency in patients with partial-onset seizures with or without secondary generalization who were not adequately controlled with 1 to 3 concomitant antiepileptic drugs.
The median reduction in seizure frequency per 28 days was 36.3% in patients treated with cenobamate 100 mg/day (n = 108), 55.2% to 55.6% in patients treated with cenobamate 200 mg/day (n = 222), and 55.3% in patients treated with cenobamate 400 mg/day (n = 111) compared to 21.5% to 24.3% in patients given placebo (n = 214) in 2 clinical trials with 6-week titration phases and 6- to 12-week maintenance phases.
A higher percentage of subjects who took cenobamate during placebo-controlled clinical trials had a QT interval shortening of more than 20 milliseconds compared to placebo.
Reductions in the QT interval below 300 milliseconds were not observed.
Cenobamate is also associated with dose-related dizziness, drowsiness, fatigue, and gait disturbance or coordination-related adverse reactions
Indications
- partial seizures
Side Effects
- abdominal pain
- amnesia
- anorexia
- aphasia
- asthenia
- ataxia
- back pain
- blurred vision
- confusion
- constipation
- cystitis
- diarrhea
- diplopia
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysarthria
- dysgeusia
- dysmenorrhea
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- euphoria
- fatigue
- headache
- hiccups
- hyperkalemia
- irritability
- lethargy
- maculopapular rash
- malaise
- memory impairment
- migraine
- musculoskeletal pain
- nausea
- nystagmus
- palpitations
- pharyngitis
- pruritus
- psychomotor impairment
- shortened QT interval
- suicidal ideation
- tremor
- vertigo
- vomiting
- weight loss
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- breast-feeding
- depression
- dialysis
- driving or operating machinery
- geriatric
- hepatic disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- short QT syndrome
- shortened QT interval
- suicidal ideation
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