Cenobamate

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Cenobamate Brand Name– XCOPRI

What is Cenobamate

Cenobamate is an oral antiepileptic drug indicated for partial-onset seizures in adults.

In placebo-controlled clinical trials, cenobamate significantly decreased seizure frequency in patients with partial-onset seizures with or without secondary generalization who were not adequately controlled with 1 to 3 concomitant antiepileptic drugs.

The median reduction in seizure frequency per 28 days was 36.3% in patients treated with cenobamate 100 mg/day (n = 108), 55.2% to 55.6% in patients treated with cenobamate 200 mg/day (n = 222), and 55.3% in patients treated with cenobamate 400 mg/day (n = 111) compared to 21.5% to 24.3% in patients given placebo (n = 214) in 2 clinical trials with 6-week titration phases and 6- to 12-week maintenance phases.

A higher percentage of subjects who took cenobamate during placebo-controlled clinical trials had a QT interval shortening of more than 20 milliseconds compared to placebo.

Reductions in the QT interval below 300 milliseconds were not observed.

Cenobamate is also associated with dose-related dizziness, drowsiness, fatigue, and gait disturbance or coordination-related adverse reactions

Indications

  • partial seizures

Side Effects

  1. abdominal pain
  2. amnesia
  3. anorexia
  4. aphasia
  5. asthenia
  6. ataxia
  7. back pain
  8. blurred vision
  9. confusion
  10. constipation
  11. cystitis
  12. diarrhea
  13. diplopia
  14. dizziness
  15. drowsiness
  16. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  17. dysarthria
  18. dysgeusia
  19. dysmenorrhea
  20. dyspepsia
  21. dyspnea
  22. elevated hepatic enzymes
  23. euphoria
  24. fatigue
  25. headache
  26. hiccups
  27. hyperkalemia
  28. irritability
  29. lethargy
  30. maculopapular rash
  31. malaise
  32. memory impairment
  33. migraine
  34. musculoskeletal pain
  35. nausea
  36. nystagmus
  37. palpitations
  38. pharyngitis
  39. pruritus
  40. psychomotor impairment
  41. shortened QT interval
  42. suicidal ideation
  43. tremor
  44. vertigo
  45. vomiting
  46. weight loss
  47. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • breast-feeding
  • depression
  • dialysis
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • short QT syndrome
  • shortened QT interval
  • suicidal ideation

Interactions

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