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Acetaminophen and Dextromethorphan Brand Names
Delsym Children’s Cough + Sore Throat | Delsym Cough + Sore Throat | PediaCare Cough & Sore Throat Plus Acetaminophen | Robitussin CF MAX Severe Cough + Sore Throat | Triaminic Cough & Sore Throat | Triaminic Cough and Sore Throat | Triaminic Cough and Sore Throat Softchew | Tylenol Children’s Cold + Cough + Sore Throat | Tylenol Children’s Plus Cough and Sore Throat | Tylenol Cough and Sore Throat
What is Acetaminophen and Dextromethorphan
Acetaminophen and dextromethorphan are used together to provide temporary relief from body aches, cough, minor pain due to a headache or sore throat, and fever.
Acetaminophen possesses analgesic and antipyretic activity similar to aspirin; however, acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function.
Acetaminophen is the preferred analgesic/antipyretic for patients in whom aspirin is contraindicated (e.g., those who have a history of gastric ulcer or a coagulation disorder).
In addition, acetaminophen has been recommended by the American Lung Association as the first line treatment for aches and pains associated with the flu. Dextromethorphan is a cough suppressant related to the opiate agonists; however, it does not exhibit typical opiate agonist characteristics.
The only morphine-like characteristic dextromethorphan retains is its antitussive property.
Dextromethorphan is effective in inhibiting dry, nonproductive coughs.
It is not intended to treat coughs associated with excessive mucus production such as may occur with smoking, emphysema, or chronic bronchitis.
Acetaminophen and dextromethorphan is available in nonprescription liquid formulations for adults and children.
Indications
- cough
- fever
- headache
- mild pain
- pharyngitis
For relief from body aches, cough, mild pain due to a headache or sore throat (pharyngitis), and fever
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- bleeding
- confusion
- contact dermatitis
- dizziness
- drowsiness
- dysarthria
- encephalopathy
- erythema
- excitability
- exfoliative dermatitis
- fatigue
- fever
- hemolysis
- hemolytic anemia
- hepatic necrosis
- hypoprothrombinemia
- interstitial nephritis
- irritability
- jaundice
- maculopapular rash
- methemoglobinemia
- myocarditis
- nausea
- pancytopenia
- pruritus
- purpura
- rash
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- restlessness
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN: in chronic use or acute toxicity
Contraindications
- alcoholism
- asthma
- bone marrow suppression
- breast-feeding
- bronchitis
- children
- chronic obstructive pulmonary disease (COPD)
- driving or operating machinery
- emphysema
- G6PD deficiency
- geriatric
- heart failure
- hepatic disease
- hepatitis
- immunosuppression
- infants
- infection
- MAOI therapy
- neonates
- neutropenia
- pregnancy
- renal disease
- renal failure
- renal impairment
- tobacco smoking
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abiraterone
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Codeine
- Alfentanil
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Antacids
- Aprepitant, Fosaprepitant
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Busulfan
- Butabarbital
- Carbamazepine
- Celecoxib
- Charcoal
- Chloroprocaine
- Chlorpheniramine; Codeine
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Cinacalcet
- Citalopram
- Clobazam
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dacomitinib
- Dapsone
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desvenlafaxine
- Diflunisal
- Donepezil; Memantine
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Escitalopram
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Exenatide
- Fedratinib
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Givosiran
- grapefruit juice
- Hydantoins
- Hydroxyprogesterone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Imatinib
- Insulin Glargine; Lixisenatide
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lanthanum Carbonate
- Lasmiditan
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Linezolid
- Lixisenatide
- Lomitapide
- Lopinavir; Ritonavir
- Lorcaserin
- Magnesium Salicylate
- Memantine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methylene Blue
- Metyrapone
- Milnacipran
- Mipomersen
- Mirabegron
- Mirtazapine
- Mitotane
- Monoamine oxidase inhibitors
- Nefazodone
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Ozanimod
- Panobinostat
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pentobarbital
- Phenelzine
- Phenobarbital
- Pneumococcal Vaccine, Polyvalent
- Posaconazole
- Pramlintide
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Propafenone
- Quinine
- Rasagiline
- Rifabutin
- Rifampin
- Ritonavir
- Rolapitant
- Ropivacaine
- Safinamide
- Salsalate
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Sodium Bicarbonate
- St. John’s Wort, Hypericum perforatum
- Sulfinpyrazone
- Tedizolid
- Telaprevir
- Telotristat Ethyl
- Terbinafine
- Tetracaine
- Thiopental
- Tizanidine
- tobacco
- Tocilizumab
- Tranylcypromine
- Tricyclic antidepressants
- Trimetrexate
- Vemurafenib
- Venlafaxine
- Vilazodone
- Vortioxetine
- Warfarin
- Zidovudine, ZDV
- Zolmitriptan