Cefotetan Brand Name– Cefotan
What is Cefotetan
Cefotetan is a parenteral cephamycin antibiotic that is classified as a second-generation cephalosporin. Other second-generation cephamycins include cefoxitin and cefmetazole.
Cefotetan differs from most other cephalosporins in its activity against anaerobic organisms, particularly B. fragilis. It also has a somewhat longer half-life, allowing for twice-daily dosing, compared with cefoxitin which requires usual dosing of 4 times daily.
Therapeutic uses include abdominal and soft-tissue infections, respiratory tract infections, and urinary tract infections.
Cefotetan was FDA-approved in December 1985.
Indications
- Bacteroides fragilis
- Bacteroides splanchnicus
- Bacteroides vulgatus
- bone and joint infections
- Citrobacter freundii
- Citrobacter koseri
- Citrobacter sp.
- Clostridium sp.
- Escherichia coli
- Fusobacterium sp.
- gynecologic infections
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal infections
- Klebsiella pneumoniae
- Klebsiella sp.
- lower respiratory tract infections
- Moraxella catarrhalis
- Morganella morganii
- Neisseria gonorrhoeae
- pelvic inflammatory disease (PID)
- Peptococcus niger
- Peptostreptococcus sp.
- Porphyromonas asaccharolytica
- Prevotella bivia
- Prevotella disiens
- Prevotella melaninogenica
- Prevotella oralis
- Propionibacterium sp.
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Salmonella sp.
- Serratia marcescens
- Serratia sp.
- Shigella sp.
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- surgical infection prophylaxis
- tubo-ovarian abscess
- urinary tract infection (UTI)
- Veillonella sp.
- Yersinia enterocolitica
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactoid reactions
- angioedema
- aplastic anemia
- azotemia
- bleeding
- candidiasis
- cholestasis
- colitis
- diarrhea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- hemolytic anemia
- hyperbilirubinemia
- injection site reaction
- interstitial nephritis
- leukopenia
- nausea
- neutropenia
- pancytopenia
- phlebitis
- pruritus
- pseudomembranous colitis
- rash
- seizures
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- prothrombin time (PT)
- serum creatinine/BUN
Contraindications
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- diarrhea
- ethanol ingestion
- geriatric
- GI disease
- hemolytic anemia
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- sexually transmitted disease
- ulcerative colitis
- vitamin K deficiency
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Amikacin
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Choline Salicylate; Magnesium Salicylate
- Diflunisal
- Ethanol
- Gentamicin
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Kanamycin
- Loop diuretics
- Magnesium Salicylate
- Oral Contraceptives
- Paromomycin
- Plazomicin
- Salicylates
- Salsalate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Streptomycin
- Tobramycin
- Warfarin
