Carteolol Brand Names- Cartrol | Ocupress
What is Carteolol
Carteolol is a long-acting, nonselective, beta-adrenergic antagonist. It has been used orally for the treatment of hypertension; oral carteolol tablets are no longer commercially available in the US.
Carteolol is currently available as an ophthalmic agent applied topically for the treatment of chronic open-angle glaucoma or ocular hypertension.
Carteolol can be administered alone or in combination with other antiglaucomatous agents. The drug has low lipid solubility and moderate intrinsic sympathomimetic activity (ISA).
Beta-adrenergic antagonists with ISA theoretically have a reduced risk of bronchospasm, heart failure, and peripheral vasoconstriction.
The FDA approved carteolol in December 1988.
Indications
- glaucoma
- ocular hypertension
For the treatment of chronic open-angle glaucoma and ocular hypertension either alone or in combination with other intraocular pressure lowering agents
Side Effects
- asthenia
- AV block
- blepharitis
- blurred vision
- bradycardia
- bronchospasm
- conjunctival hyperemia
- conjunctivitis
- depression
- dizziness
- dysgeusia
- dyspnea
- headache
- heart failure
- hyperglycemia
- hypoglycemia
- hypotension
- insomnia
- lacrimation
- nausea
- night blindness
- ocular irritation
- palpitations
- photophobia
- ptosis
- rash
- respiratory arrest
- sinusitis
- stroke
- syncope
Monitoring Parameters
- blood pressure
- heart rate
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- acute bronchospasm
- asthma
- AV block
- bradycardia
- breast-feeding
- bronchitis
- cardiogenic shock
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- contact lenses
- depression
- diabetes mellitus
- driving or operating machinery
- emphysema
- geriatric
- heart failure
- hyperthyroidism
- hypoglycemia
- hypotension
- infants
- myasthenia gravis
- neonates
- peripheral vascular disease
- pheochromocytoma
- pregnancy
- psoriasis
- pulmonary disease
- pulmonary edema
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- sick sinus syndrome
- surgery
- thyrotoxicosis
- vasospastic angina
- ventricular dysfunction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
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- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
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- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
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- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
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