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Carisoprodol Brand Names- Soma | Vanadom
What is Carisoprodol
Carisoprodol is a central-acting, oral skeletal muscle relaxant indicated for relief of acute, painful musculoskeletal conditions.
It is an older drug that is less frequently used due to the availability of newer agents. One of its metabolites is meprobamate, a commercially available anxiolytic agent. It is unclear, however, whether this metabolite is generated in quantities sufficient to produce a clinical effect.
Carisoprodol is a controlled substance; abuse, dependence, withdrawal, misuse, and criminal diversion have been reported.
To limit risks associated with carisoprodol, use is recommended for no more than 2 to 3 weeks and at the lowest effective dose.
Carisoprodol (350 mg) was approved by the FDA in 1959.
A lower strength carisoprodol tablet (250 mg) received FDA approval in September 2007.
Indications
- musculoskeletal pain
For treatment of musculoskeletal pain associated with acute, painful musculoskeletal conditions
Side Effects
- agitation
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- asthenia
- ataxia
- bronchospasm
- confusion
- depression
- diplopia
- dizziness
- drowsiness
- dysarthria
- dyspepsia
- eosinophilia
- erythema multiforme
- euphoria
- fever
- flushing
- headache
- hypotension
- impaired cognition
- insomnia
- irritability
- lethargy
- leukopenia
- muscle paralysis
- mydriasis
- nausea
- orthostatic hypotension
- pancytopenia
- pruritus
- psychological dependence
- rash
- seizures
- sinus tachycardia
- syncope
- tremor
- urticaria
- vertigo
- visual impairment
- vomiting
- weakness
- withdrawal
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- Asian patients
- breast-feeding
- carbamate hypersensitivity
- children
- CNS depression
- driving or operating machinery
- geriatric
- hepatic disease
- infants
- neonates
- porphyria
- pregnancy
- renal disease
- renal failure
- renal impairment
- seizure disorder
- substance abuse
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alprazolam
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Apomorphine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Bacitracin
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Bortezomib
- Botulinum Toxins
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Cimetidine
- Clemastine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyproheptadine
- Delavirdine
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Entacapone
- Enzalutamide
- Esketamine
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Eszopiclone
- Ethanol
- Fedratinib
- Felbamate
- Fenofibric Acid
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Fosphenytoin
- Gabapentin
- General anesthetics
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Imipramine
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levorphanol
- Lofexidine
- Lorazepam
- Loxapine
- Luliconazole
- Lumacaftor; Ivacaftor
- Lumateperone
- Maprotiline
- Meclizine
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Methadone
- Methohexital
- Methscopolamine
- Metyrapone
- Midazolam
- Mirtazapine
- Modafinil
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nortriptyline
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Oxazepam
- Oxcarbazepine
- Oxycodone
- Oxymorphone
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Phenytoin
- Pregabalin
- Primidone
- Prochlorperazine
- Promethazine
- Protriptyline
- Quazepam
- Remifentanil
- Rifampin
- Rucaparib
- Secobarbital
- Sedating H1-blockers
- Sodium Oxybate
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tapentadol
- Temazepam
- Thalidomide
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Ticlopidine
- Tolcapone
- Tramadol
- Trazodone
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Valerian, Valeriana officinalis
- Voriconazole
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
