Carisoprodol

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Carisoprodol Brand Names- Soma | Vanadom

What is Carisoprodol

Carisoprodol is a central-acting, oral skeletal muscle relaxant indicated for relief of acute, painful musculoskeletal conditions.

It is an older drug that is less frequently used due to the availability of newer agents. One of its metabolites is meprobamate, a commercially available anxiolytic agent. It is unclear, however, whether this metabolite is generated in quantities sufficient to produce a clinical effect.

Carisoprodol is a controlled substance; abuse, dependence, withdrawal, misuse, and criminal diversion have been reported.

To limit risks associated with carisoprodol, use is recommended for no more than 2 to 3 weeks and at the lowest effective dose.

Carisoprodol (350 mg) was approved by the FDA in 1959.

A lower strength carisoprodol tablet (250 mg) received FDA approval in September 2007.

Indications

  • musculoskeletal pain

For treatment of musculoskeletal pain associated with acute, painful musculoskeletal conditions

Side Effects

  1. agitation
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angioedema
  5. asthenia
  6. ataxia
  7. bronchospasm
  8. confusion
  9. depression
  10. diplopia
  11. dizziness
  12. drowsiness
  13. dysarthria
  14. dyspepsia
  15. eosinophilia
  16. erythema multiforme
  17. euphoria
  18. fever
  19. flushing
  20. headache
  21. hypotension
  22. impaired cognition
  23. insomnia
  24. irritability
  25. lethargy
  26. leukopenia
  27. muscle paralysis
  28. mydriasis
  29. nausea
  30. orthostatic hypotension
  31. pancytopenia
  32. pruritus
  33. psychological dependence
  34. rash
  35. seizures
  36. sinus tachycardia
  37. syncope
  38. tremor
  39. urticaria
  40. vertigo
  41. visual impairment
  42. vomiting
  43. weakness
  44. withdrawal
  45. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • abrupt discontinuation
  • Asian patients
  • breast-feeding
  • carbamate hypersensitivity
  • children
  • CNS depression
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • infants
  • neonates
  • porphyria
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • substance abuse

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Alprazolam
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Apomorphine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Bacitracin
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Bortezomib
  • Botulinum Toxins
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Cimetidine
  • Clemastine
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclizine
  • Cyproheptadine
  • Delavirdine
  • Desipramine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Entacapone
  • Enzalutamide
  • Esketamine
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Fedratinib
  • Felbamate
  • Fenofibric Acid
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • Fosphenytoin
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Imipramine
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lofexidine
  • Lorazepam
  • Loxapine
  • Luliconazole
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Maprotiline
  • Meclizine
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mesoridazine
  • Methadone
  • Methohexital
  • Methscopolamine
  • Metyrapone
  • Midazolam
  • Mirtazapine
  • Modafinil
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nortriptyline
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oritavancin
  • Oxazepam
  • Oxcarbazepine
  • Oxycodone
  • Oxymorphone
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pregabalin
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Protriptyline
  • Quazepam
  • Remifentanil
  • Rifampin
  • Rucaparib
  • Secobarbital
  • Sedating H1-blockers
  • Sodium Oxybate
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Thalidomide
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Ticlopidine
  • Tolcapone
  • Tramadol
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Triprolidine
  • Valerian, Valeriana officinalis
  • Voriconazole
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem

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