Aspirin Carisoprodol Codeine

Aspirin Carisoprodol Codeine Brand Name– Soma Compound with Codeine

What is Aspirin Carisoprodol Codeine

Aspirin, carisoprodol, and codeine are used together in an oral preparation to treat pain and painful musculoskeletal conditions.

Aspirin is a salicylate analgesic. Codeine is an opiate analgesic. Carisoprodol is a central-acting skeletal muscle relaxant.

One metabolite of carisoprodol is meprobamate, which is a commercially available anxiolytic agent. It is unclear, however, whether this metabolite is generated in quantities sufficient to produce a clinical effect.

Dependence, withdrawal, and abuse of both carisoprodol and codeine has been reported with prolonged use; a 2 to 3 week maximum therapy duration is recommended for this combination. Due to metabolism of carisoprodol to meprobamate via CYP2C19 and codeine to morphine via CYP2D6, drug interactions and variable patient response are possible.

Codeine is a prodrug that must be hepatically metabolized to morphine to provide effective analgesia.

Codeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.

Codeine use is contraindicated in pediatric patients younger than 12 years.

The American Academy of Pediatrics (AAP) recommends against the use of codeine and codeine-containing products in all pediatric patients for any indication.

Indications

  • muscle spasm
  • musculoskeletal pain

For the treatment of acute, painful musculoskeletal conditions (e.g., musculoskeletal pain, muscle spasm)

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactoid reactions
  4. anorexia
  5. ataxia
  6. bronchospasm
  7. constipation
  8. depression
  9. dizziness
  10. drowsiness
  11. elevated hepatic enzymes
  12. flushing
  13. gastritis
  14. GI bleeding
  15. GI obstruction
  16. GI perforation
  17. headache
  18. hematemesis
  19. insomnia
  20. interstitial nephritis
  21. intracranial bleeding
  22. irritability
  23. leukopenia
  24. melena
  25. miosis
  26. nausea
  27. neonatal opioid withdrawal syndrome
  28. orthostatic hypotension
  29. pancytopenia
  30. peptic ulcer
  31. physiological dependence
  32. pruritus
  33. psychological dependence
  34. purpura
  35. rash
  36. renal failure (unspecified)
  37. respiratory arrest
  38. respiratory depression
  39. seizures
  40. sinus tachycardia
  41. stool discoloration
  42. syncope
  43. tinnitus
  44. tremor
  45. vertigo
  46. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • accidental exposure
  • acute abdomen
  • adenoidectomy
  • alcoholism
  • anticoagulant therapy
  • Asian patients
  • asthma
  • biliary tract disease
  • Black patients
  • bradycardia
  • breast-feeding
  • carbamate hypersensitivity
  • Caucasian patients
  • children
  • chronic obstructive pulmonary disease (COPD)
  • CNS depression
  • coadministration with other CNS depressants
  • constipation
  • dehydration
  • driving or operating machinery
  • geriatric
  • GI bleeding
  • GI disease
  • GI obstruction
  • GI perforation
  • head trauma
  • hepatic disease
  • Hispanic patients
  • hypotension
  • hypovolemia
  • ileus
  • increased intracranial pressure
  • infants
  • inflammatory bowel disease
  • influenza
  • labor
  • MAOI therapy
  • nasal polyps
  • neonatal opioid withdrawal syndrome
  • neonates
  • neurological disease
  • obesity
  • obstetric delivery
  • orthostatic hypotension
  • pancreatitis
  • peptic ulcer disease
  • porphyria
  • potential for overdose or poisoning
  • pregnancy
  • pulmonary disease
  • renal impairment
  • respiratory depression
  • respiratory infection
  • respiratory insufficiency
  • Reye’s syndrome
  • seizure disorder
  • seizures
  • sleep apnea
  • substance abuse
  • tonsillectomy
  • ulcerative colitis
  • urinary retention
  • varicella
  • viral infection

Interactions

  • Abciximab
  • Abiraterone
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Acidifying Agents
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  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
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  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroprocaine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cidofovir
  • Cilostazol
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  • Codeine; Phenylephrine; Promethazine
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  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
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  • Dextromethorphan; Guaifenesin; Phenylephrine
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  • Diazepam
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  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
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  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
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  • grapefruit juice
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  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Penicillins
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Pentosan
  • Pentoxifylline
  • Perampanel
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Photosensitizing agents (topical)
  • Pimozide
  • Pioglitazone
  • Piperacillin
  • Piperacillin; Tazobactam
  • Piroxicam
  • Pneumococcal Vaccine, Polyvalent
  • Polymyxins
  • Posaconazole
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prasugrel
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Probenecid
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propofol
  • Protriptyline
  • Psyllium
  • Quazepam
  • Quetiapine
  • Quinapril
  • Quinidine
  • Quinine
  • Ramelteon
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Repaglinide
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Risperidone
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivaroxaban
  • Rizatriptan
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rosiglitazone
  • Rotigotine
  • Rucaparib
  • Safinamide
  • Salicylic Acid
  • Saquinavir
  • Saxagliptin
  • Secobarbital
  • Sedating H1-blockers
  • Selective serotonin reuptake inhibitors
  • Selegiline
  • Selpercatinib
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Sildenafil
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Skeletal Muscle Relaxants
  • Sodium Bicarbonate
  • Sodium Hyaluronate, Hyaluronic Acid
  • Sodium Lactate
  • Sodium Oxybate
  • Sodium Thiosulfate; Salicylic Acid
  • Solifenacin
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sufentanil
  • Sulfinpyrazone
  • Sulfonamides
  • Sulfonylureas
  • Sulindac
  • Sumatriptan
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Terbinafine
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thrombin Inhibitors
  • Thrombolytic Agents
  • Ticagrelor
  • Ticarcillin
  • Ticarcillin; Clavulanic Acid
  • Ticlopidine
  • Tinzaparin
  • Tipranavir
  • Tirofiban
  • Tizanidine
  • Tolazamide
  • Tolbutamide
  • Tolcapone
  • Tolmetin
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Tromethamine
  • Trospium
  • Tucatinib
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vancomycin
  • Varicella-Zoster Virus Vaccine, Live
  • Venlafaxine
  • Verapamil
  • Verteporfin
  • Vigabatrin
  • Vilazodone
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Warfarin
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
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