Carbenicillin Brand Name– Geocillin
What is Carbenicillin
Carbenicillin is an oral, extended-spectrum penicillin. It was the first semisynthetic, extended-spectrum penicillin marketed.
At that time, carbenicillin had increased activity against aerobic gram-negative rods than did other available penicillins.
Since then, clinical use of carbenicillin has been replaced by other extended-spectrum penicillins such as mezlocillin and piperacillin, which are more effective against gram-negative organisms.
Parenteral carbenicillin is no longer available. Oral carbenicillin occasionally is used when an oral agent is needed for the treatment of Pseudomonas UTIs.
Carbenicillin was approved by the FDA in 1970.
Indications
- Bacillus anthracis
- Enterobacter sp.
- Enterococcus faecalis
- Enterococcus sp.
- Escherichia coli
- Gardnerella vaginalis
- Haemophilus influenzae (beta-lactamase negative)
- Listeria monocytogenes
- Moraxella sp.
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Pasteurella multocida
- prostatitis
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Pseudomonas sp.
- Salmonella sp.
- Shigella sp.
- Staphylococcus sp.
- Streptococcus sp.
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- arthralgia
- bleeding
- bullous rash
- candidiasis
- chills
- diarrhea
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema nodosum
- exfoliative dermatitis
- fever
- flatulence
- fluid retention
- glossitis
- headache
- hypernatremia
- hyperthermia
- hypokalemia
- interstitial nephritis
- leukopenia
- maculopapular rash
- malaise
- myalgia
- nausea
- nephrotic syndrome
- neutropenia
- ocular pruritus
- platelet dysfunction
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- purpura
- rash
- renal tubular necrosis
- seizures
- serum sickness
- Stevens-Johnson syndrome
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vasculitis
- vomiting
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- children
- coagulopathy
- colitis
- cystic fibrosis
- diarrhea
- eczema
- geriatric
- GI disease
- hemophilia
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- ulcerative colitis
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Betrixaban
- Bivalirudin
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Digoxin
- Edoxaban
- Enoxaparin
- Ethacrynic Acid
- Fondaparinux
- Furosemide
- Heparin
- Indomethacin
- Lepirudin
- Magnesium Salicylate
- Methotrexate
- Oral Contraceptives
- Pentosan
- Probenecid
- Rivaroxaban
- Salsalate
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tetracyclines
- Tinzaparin
- Typhoid Vaccine
- Warfarin
