Carbamide Peroxide

Carbamide Peroxide Brand Names

Auro Ear | Auro Earache Relief | Canal + Gel | Debrox | Ear Drops 

What is Carbamide Peroxide

Carbamide peroxide, also known as urea hydrogen peroxide, is an otic and topical (oral) preparation. The otic formulations are used to remove ear wax (cerumen) impaction.

Mineral oil, olive oil, and dilute hydrogen peroxide solutions are inexpensive agents used to soften ear wax. One in-vitro study demonstrated that liquid docusate sodium had better efficacy than carbamide peroxide in dissolving ear wax.

Oral carbamide peroxide solutions are antiseptics used in the treatment of canker sores (apthous ulcers), gingivitis, and in minor irritations.

Topical carbamide peroxide can also be used as an adjunct to oral hygiene after regular brushing or when normal oral hygiene is not possible.

Safety and efficacy data for oral use of carbamide peroxide is lacking. Many cosmetic dental whitening systems contain carbamide peroxide 10—20% as the active ingredient.


  1. aphthous ulcer
  2. cerumen removal
  3. dental pain
  4. gingivitis
  5. periodontitis
  6. stomatitis

Side Effects

  1. erythema
  2. pruritus
  3. rash

Monitoring Parameters

  • laboratory monitoring not necessary


  • bleeding
  • breast-feeding
  • children
  • ear discharge
  • fever
  • hearing impairment
  • infants
  • neonates
  • otitis media
  • pain
  • pregnancy
  • tinnitus
  • tobacco smoking
  • tympanic membrane perforation


There are no drug interactions associated with Carbamide Peroxide products.


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