Cabergoline

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Cabergoline Brand Name– Dostinex

What is Cabergoline

Cabergoline is a synthetic ergoline-derived dopamine agonist that is indicated for the treatment of hyperprolactinemic disorders, either idiopathic or because of pituitary adenomas.

Until the availability of cabergoline in 1996, bromocriptine was the only agent approved by the FDA for the treatment of hyperprolactinemias.

Results from comparative studies of the two medications indicate that cabergoline is more effective than bromocriptine in suppressing prolactin secretion and it has a more favorable tolerability profile. In addition, the unique dosing strategy of cabergoline is a potential advantage of the drug.

Whereas bromocriptine requires multiple daily dosages for effectiveness, cabergoline has a long half-life and is administered once to twice weekly for hyperprolactinemia.

Although there is evidence for the efficacy of cabergoline in the treatment of restless legs syndrome, the drug is rarely used in clinical practice because of the risk of cardiac valvulopathy and the availability of safer alternatives.

Indications

  • hyperprolactinemia
  • pituitary adenoma
  • restless legs syndrome (RLS)

For the treatment of hyperprolactinemia, either idiopathic or due to a pituitary adenoma

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. alopecia
  4. anorexia
  5. anxiety
  6. arthralgia
  7. asthenia
  8. cardiac valvulopathy
  9. confusion
  10. constipation
  11. cough
  12. dental pain
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. dyskinesia
  17. dysmenorrhea
  18. dyspepsia
  19. edema
  20. epistaxis
  21. fatigue
  22. flatulence
  23. fluid retention
  24. hallucinations
  25. headache
  26. heart failure
  27. hot flashes
  28. hypotension
  29. impulse control symptoms
  30. insomnia
  31. libido increase
  32. malaise
  33. mastalgia
  34. musculoskeletal pain
  35. nasal congestion
  36. nausea
  37. orthostatic hypotension
  38. palpitations
  39. paresthesias
  40. peptic ulcer
  41. pericarditis
  42. peripheral edema
  43. pleural effusion
  44. pruritus
  45. psychosis
  46. pulmonary fibrosis
  47. retroperitoneal fibrosis
  48. rhinitis
  49. syncope
  50. throat irritation
  51. vertigo
  52. visual impairment
  53. vomiting
  54. weight gain
  55. weight loss
  56. xerostomia

Monitoring Parameters

  • blood pressure
  • chest x-ray
  • echocardiogram
  • LFTs
  • serum creatinine
  • serum prolactin

Contraindications

  • breast-feeding
  • children
  • constrictive pericarditis
  • eclampsia
  • ergot alkaloid hypersensitivity
  • geriatric
  • hepatic disease
  • hypertension
  • hypotension
  • impulse control symptoms
  • infants
  • orthostatic hypotension
  • preeclampsia
  • pregnancy
  • pregnancy testing
  • pulmonary fibrosis
  • retroperitoneal fibrosis
  • valvular heart disease

Interactions

  • Acebutolol
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alpha-blockers
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amyl Nitrite
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Aripiprazole
  • Asenapine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Beta-blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brexpiprazole
  • Brimonidine; Timolol
  • Bumetanide
  • Caffeine; Ergotamine
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Chlorothiazide
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Clomipramine
  • Clonidine
  • Clozapine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Deutetrabenazine
  • Dextromethorphan; Promethazine
  • Diethylpropion
  • Dihydroergotamine
  • Diltiazem
  • Dorzolamide; Timolol
  • Doxazosin
  • Droperidol
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Esmolol
  • Ethacrynic Acid
  • Felodipine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Guanfacine
  • Haloperidol
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Iloperidone
  • Indapamide
  • Irbesartan
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Isradipine
  • Labetalol
  • Levobetaxolol
  • Levobunolol
  • Lisinopril
  • Loop diuretics
  • Lorcaserin
  • Losartan
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Mecamylamine
  • Meperidine; Promethazine
  • Mesoridazine
  • Methyclothiazide
  • Methyldopa
  • Methylergonovine
  • Methysergide
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Minoxidil
  • Moexipril
  • Molindone
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nicardipine
  • Nifedipine
  • Nisoldipine
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Olanzapine
  • Olmesartan
  • Paliperidone
  • Penbutolol
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenothiazines
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine; Promethazine
  • Pimozide
  • Pindolol
  • Potassium-sparing diuretics
  • Prazosin
  • Prochlorperazine
  • Promethazine
  • Propranolol
  • Quetiapine
  • Quinapril
  • Ramelteon
  • Ramipril
  • Reserpine
  • Risperidone
  • Sacubitril; Valsartan
  • Sotalol
  • Spironolactone
  • Telmisartan
  • Terazosin
  • Tetrabenazine
  • Thiazide diuretics
  • Thiethylperazine
  • Thioridazine
  • Thiothixene
  • Timolol
  • tobacco
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamterene
  • Trifluoperazine
  • Valbenazine
  • Valsartan
  • Verapamil
  • Ziprasidone

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