Benazepril Hydrochlorothiazide Brand Name– Lotensin HCT
What is Benazepril Hydrochlorothiazide
Benazepril and hydrochlorothiazide are used together in an oral preparation to treat hypertension.
These ingredients have additive hypotensive activity. Hydrochlorothiazide is a thiazide diuretic.
Benazepril is an angiotensin-converting enzyme (ACE) inhibitor.
Benazepril can counteract the hypokalemia caused by hydrochlorothiazide. Benazepril is a prodrug that is hydrolyzed by esterases to the active metabolite benazeprilat, whose long duration of action makes benazepril suitable for once daily dosing.
Pharmacodynamically, benazepril most closely resembles fosinopril, quinapril, and ramipril. Neither benazepril nor benazeprilat contain a sulfhydryl group, which has implications regarding the drug’s adverse reactions profile.
Although benazepril monotherapy is less effective in black hypertensive patients (a low-renin hypertensive population), efficacy with benazepril; hydrochlorothiazide (Lotensin HCT®) appears to be independent of race.
Lotensin HCT® was granted FDA approval for the treatment of hypertension on May 19, 1992.
Generic benazepril hydrochlorothiazide was approved in February 2004.
Indications
- hypertension
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactoid reactions
- angioedema
- anorexia
- anuria
- aplastic anemia
- arthralgia
- asthenia
- azotemia
- back pain
- blurred vision
- bronchospasm
- chest pain (unspecified)
- chills
- constipation
- cough
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- epistaxis
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- flushing
- gout
- headache
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypertonia
- hypertriglyceridemia
- hyperuricemia
- hypoesthesia
- hypokalemia
- hypomagnesemia
- hypotension
- hypovolemia
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- influenza
- insomnia
- jaundice
- leukopenia
- libido decrease
- myalgia
- myopia
- nausea
- nephrolithiasis
- neutropenia
- ocular hypertension
- oliguria
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- pemphigus
- photosensitivity
- pneumonitis
- pruritus
- rash
- renal failure (unspecified)
- rhinitis
- sialadenitis
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- syncope
- teratogenesis
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- vertigo
- visual impairment
- vomiting
- xanthopsia
- xerostomia
Monitoring Parameters
- blood glucose
- blood pressure
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- ACE-inhibitor induced angioedema
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- anuria
- asthma
- atopy
- autoimmune disease
- Black patients
- bone marrow suppression
- breast-feeding
- cerebrovascular disease
- children
- collagen-vascular disease
- coronary artery disease
- diabetes mellitus
- dialysis
- electrolyte imbalance
- geriatric
- gout
- heart failure
- hepatic disease
- hereditary angioedema
- history of angioedema
- hymenoptera venom (insect sting) allergy desensitization
- hyperglycemia
- hyperkalemia
- hyperuricemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- immunosuppression
- low-density lipoprotein apheresis
- orthostatic hypotension
- pancreatitis
- penicillin hypersensitivity
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- scleroderma
- sulfonamide hypersensitivity
- sunlight (UV) exposure
- surgery
- sympathectomy
- syncope
- systemic lupus erythematosus (SLE)
- thiazide diuretic hypersensitivity
Interactions
- Acarbose
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alemtuzumab
- Alendronate; Cholecalciferol
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Allopurinol
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Amyl Nitrite
- Angiotensin II
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Apraclonidine
- Aprotinin
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atracurium
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azathioprine
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Beta-agonists
- Bortezomib
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Cabergoline
- Calcium
- Calcium Phosphate, Supersaturated
- Calcium; Vitamin D
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
- Carvedilol
- Celecoxib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Cholestyramine
- Cidofovir
- Cisapride
- Cisatracurium
- Citalopram
- Clindamycin; Tretinoin
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Colestipol
- Conivaptan
- Corticosteroids
- Cosyntropin
- Cyclophosphamide
- Cyclosporine
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexlansoprazole
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dicyclomine
- Diethylpropion
- Diflunisal
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dofetilide
- Dolasetron
- Donepezil; Memantine
- Dopamine
- Doxacurium
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Duloxetine
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entecavir
- Ephedrine
- Epinephrine
- Eplerenone
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergocalciferol, Vitamin D2
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethanol
- Etodolac
- Etomidate
- Everolimus
- Exenatide
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flavoxate
- Fluconazole
- Fluocinolone; Hydroquinone; Tretinoin
- Fluorescein
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Gallium Ga 68 Dotatate
- General anesthetics
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Gold
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halobetasol; Tazarotene
- Halofantrine
- Haloperidol
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen lysine
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icatibant
- Icosapent ethyl
- Iloperidone
- Iloprost
- Inamrinone
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Indomethacin
- Inotersen
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Intravenous Lipid Emulsions
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Iron Dextran
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isosulfan Blue
- Kanamycin
- Ketamine
- Ketoprofen
- Ketorolac
- Lansoprazole
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lesinurad; Allopurinol
- Levalbuterol
- Levodopa
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lixisenatide
- Loop diuretics
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin; Niacin
- Lurasidone
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Mannitol
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Meloxicam
- Memantine
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mequinol; Tretinoin
- Mestranol; Norethindrone
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methazolamide
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methotrexate
- Methoxsalen
- Methscopolamine
- Methylphenidate
- Metoclopramide
- Midodrine
- Miglitol
- Milnacipran
- Milrinone
- Mirtazapine
- Mivacurium
- Moexipril
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol; Valsartan
- Nefazodone
- Nesiritide, BNP
- Neuromuscular blockers
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Octreotide
- Olanzapine
- Olmesartan
- Olodaterol
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oprelvekin, rh-IL-11
- Oxaprozin
- Oxybutynin
- Oxycodone
- Oxymetazoline
- Oxymorphone
- Paliperidone
- Pancuronium
- Pantoprazole
- Paroxetine
- Pasireotide
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Pimozide
- Pioglitazone
- Pirbuterol
- Piroxicam
- Polycarbophil
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Porfimer
- Potassium
- Pramlintide
- Prazosin
- Pregabalin
- Prilocaine; Epinephrine
- Probenecid
- Procainamide
- Procaine
- Propantheline
- Propofol
- Pseudoephedrine
- Quetiapine
- Quinapril
- Quinidine
- Rabeprazole
- Ramipril
- Rapacuronium
- Rasagiline
- Remifentanil
- Repaglinide
- Risperidone
- Rocuronium
- Rofecoxib
- Rosiglitazone
- Sacubitril; Valsartan
- Salicylates
- Salmeterol
- Saxagliptin
- Scopolamine
- Selegiline
- Semaglutide
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Silodosin
- Simvastatin; Sitagliptin
- Sirolimus
- Sitagliptin
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Spironolactone
- Streptozocin
- Succinylcholine
- Sufentanil
- Sulfacetamide
- Sulfacetamide; Sulfur
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfinpyrazone
- Sulfonylureas
- Sulindac
- Tacrolimus
- Tapentadol
- Tazarotene
- Tegaserod
- Telavancin
- Telbivudine
- Telmisartan
- Temsirolimus
- Terbutaline
- Tetrabenazine
- Tetracaine
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tiotropium; Olodaterol
- Tizanidine
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Tolvaptan
- Topiramate
- Toremifene
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamterene
- Trihexyphenidyl
- Trimethoprim
- Trospium
- Tubocurarine
- Umeclidinium; Vilanterol
- Valdecoxib
- Valsartan
- Vecuronium
- Venlafaxine
- Verteporfin
- Vilazodone
- Vitamin D
- Vitamin D analogs
- Vorinostat
- Vortioxetine
- Yohimbine
- Ziconotide
- Ziprasidone