Benzphetamine

Benzphetamine Brand Names- Didrex | Regimex

What is Benzphetamine

Benzphetamine is an oral, indirect-acting sympathomimetic amine that is metabolized to various amphetamines (i.e., amphetamine and methamphetamine).

Benzphetamine is used as an anorectic agent for short-term (8 to 12 weeks) adjunct treatment of exogenous obesity. Appetite-suppression activity is believed to occur by direct CNS stimulation of the satiety center in the hypothalamic and limbic regions.

Benzphetamine has a high potential for abuse and addiction.According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, short-term pharmacotherapy, such as with the amphetamine anorectics, has not been shown to produce longer-term health benefits in obese and overweight patients and cannot be generally recommended and weight loss with these agents is usually not sustained.

Benzphetamine should not be used for weight management long-term.

Benzphetamine was approved by the FDA in 1960.

Indications

  • obesity

For the short-term (i.e., 8 to 12 weeks) treatment of exogenous obesity

Side Effects

  1. abdominal pain
  2. alopecia
  3. anaphylactoid reactions
  4. angioedema
  5. anorexia
  6. anxiety
  7. bradycardia
  8. cardiomyopathy
  9. delirium
  10. diarrhea
  11. dizziness
  12. dysgeusia
  13. dyspepsia
  14. dyspnea
  15. emotional lability
  16. euphoria
  17. fatigue
  18. growth inhibition
  19. hallucinations
  20. headache
  21. hyperhidrosis
  22. hypertension
  23. hyperthermia
  24. impotence (erectile dysfunction)
  25. insomnia
  26. libido decrease
  27. libido increase
  28. mania
  29. nausea
  30. palpitations
  31. paranoia
  32. peripheral edema
  33. photosensitivity
  34. physiological dependence
  35. psychological dependence
  36. psychosis
  37. pulmonary hypertension
  38. rash
  39. restlessness
  40. rhabdomyolysis
  41. seizures
  42. serotonin syndrome
  43. sinus tachycardia
  44. Stevens-Johnson syndrome
  45. syncope
  46. tolerance
  47. toxic epidermal necrolysis
  48. tremor
  49. urticaria
  50. vomiting
  51. withdrawal
  52. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate
  • weight

Contraindications

  • abrupt discontinuation
  • alcoholism
  • angina
  • anorexia nervosa
  • arteriosclerosis
  • bipolar disorder
  • breast-feeding
  • bulimia nervosa
  • cardiac arrhythmias
  • cardiac disease
  • children
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • edema
  • geriatric
  • glaucoma
  • growth inhibition
  • hypertension
  • hyperthyroidism
  • long QT syndrome
  • mania
  • MAOI therapy
  • neonates
  • obesity treatment
  • peripheral vascular disease
  • pregnancy
  • psychosis
  • pulmonary hypertension
  • radiographic contrast administration
  • Raynaud’s phenomenon
  • schizophrenia
  • seizure disorder
  • substance abuse
  • suicidal ideation
  • surgery
  • syncope
  • thyroid disease
  • tics
  • Tourette’s syndrome
  • valvular heart disease

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Ambrisentan
  • Amifampridine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amoxapine
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  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril
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  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
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  • Brompheniramine; Carbetapentane; Phenylephrine
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  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide; Formoterol
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  • Caffeine; Ergotamine
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  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
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  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorcyclizine
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  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
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  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Quinidine
  • Digitoxin
  • Digoxin
  • Diltiazem
  • Dimenhydrinate
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  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Eplerenone
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergot alkaloids
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Escitalopram
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  • Ethosuximide
  • Etomidate
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  • Felodipine
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • food
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Gabapentin
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guanabenz
  • Guanfacine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
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  • Ketamine
  • Labetalol
  • Lacosamide
  • Lamotrigine
  • Lasmiditan
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  • Levetiracetam
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lisinopril
  • Lithium
  • Lixisenatide
  • Loop diuretics
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  • Lurasidone
  • Macitentan
  • Magnesium Hydroxide
  • Maprotiline
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  • Meclizine
  • Meglitinides
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  • Meperidine; Promethazine
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methazolamide
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Metolazone
  • Metoprolol
  • Miglitol
  • Mirtazapine
  • Modafinil
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Nabilone
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  • Omeprazole; Sodium Bicarbonate
  • Ozanimod
  • Paroxetine
  • Penbutolol
  • Perampanel
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenobarbital
  • Phenoxybenzamine
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  • Phentermine; Topiramate
  • Phentolamine
  • Phenytoin
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium-sparing diuretics
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  • Prazosin
  • Pregabalin
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  • Propofol
  • Propoxyphene
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  • Quinapril
  • Quinidine
  • Racepinephrine
  • Ramipril
  • Rasagiline
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  • Rosiglitazone
  • Rufinamide
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  • Salmeterol
  • Sedating H1-blockers
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  • Serotonin-Receptor Agonists
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  • Sodium Bicarbonate
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  • Solriamfetol
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  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
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  • Theophylline, Aminophylline
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  • Tricyclic antidepressants
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