Azelastine Fluticasone

Azelastine Fluticasone Brand Name– Dymista

What is Azelastine Fluticasone

Azelastine fluticasone is a combination of an antihistamine and a corticosteroid administered by nasal inhalation for treating the symptoms of seasonal allergic rhinitis.

Clinical trials compared azelastine fluticasone combination therapy to monotherapy with azelastine nasal spray, monotherapy with fluticasone nasal spray, or placebo.

Combination treatment demonstrated a statistically significant greater decrease in the reflective nasal symptom score compared with the single agents alone or placebo.

Combined treatment may increase compliance in patients who require treatment with both azelastine and fluticasone. Dymista nasal spray was approved in May 2012 for adult and adolescent patients >= 12 years; in February 2015, approval was expanded to pediatric patients as young as 6 years of age.

Indications

  • allergic rhinitis
  • seasonal allergies

Side Effects

  1. abdominal pain
  2. adrenocortical insufficiency
  3. anaphylactoid reactions
  4. angioedema
  5. anosmia
  6. atrial fibrillation
  7. blurred vision
  8. bronchospasm
  9. candidiasis
  10. cataracts
  11. chest pain (unspecified)
  12. Churg-Strauss syndrome
  13. confusion
  14. conjunctivitis
  15. cough
  16. dental pain
  17. diarrhea
  18. dizziness
  19. drowsiness
  20. dysgeusia
  21. dysosmia
  22. dysphonia
  23. dyspnea
  24. eosinophilia
  25. epistaxis
  26. erythema
  27. fatigue
  28. fever
  29. growth inhibition
  30. headache
  31. hoarseness
  32. hypertension
  33. hypothalamic-pituitary-adrenal (HPA) suppression
  34. immunosuppression
  35. impaired wound healing
  36. infection
  37. myalgia
  38. nasal congestion
  39. nasal dryness
  40. nasal irritation
  41. nasal septum perforation
  42. nausea
  43. ocular hypertension
  44. ocular irritation
  45. osteopenia
  46. osteoporosis
  47. palpitations
  48. paresthesias
  49. parosmia
  50. pharyngitis
  51. pruritus
  52. rash
  53. rhinalgia
  54. rhinitis
  55. rhinorrhea
  56. sinus tachycardia
  57. sinusitis
  58. sneezing
  59. throat irritation
  60. tolerance
  61. urinary retention
  62. urticaria
  63. visual impairment
  64. vomiting
  65. weight gain
  66. wheezing
  67. xerophthalmia
  68. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • cataracts
  • children
  • corticosteroid hypersensitivity
  • driving or operating machinery
  • glaucoma
  • growth inhibition
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • immunosuppression
  • increased intracranial pressure
  • increased intraocular pressure
  • infants
  • infection
  • nasal septal perforation
  • nasal surgery
  • nasal trauma
  • neonates
  • ocular exposure
  • ophthalmic administration
  • osteoporosis
  • pregnancy
  • tuberculosis
  • varicella
  • viral infection

Interactions

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