Atropine Benzoic Acid Hyoscyamine Methenamine Methylene Blue Phenyl Salicylate

Atropine Benzoic Acid Hyoscyamine Methenamine Methylene Blue Phenyl Salicylate Brand Names

MHP A | Prosed DS | Prosed EC | Trac Tabs 2X | UAA | Uretron | Urised | Uritract DS | Uritract-EC | Usept | U-Tran

What is Atropine Benzoic Acid Hyoscyamine Methenamine Methylene Blue Phenyl Salicylate

Atropine Benzoic Acid Hyoscyamine Methenamine Methylene Blue Phenyl Salicylate are used together in an oral preparation for suppression of the symptoms of irritative voiding, such as hypermotility and spasticity, that are associated with lower urinary tract infections or which are caused by diagnostic procedures.

Methenamine is an antiinfective agent, providing local bacteriostatic or bacteriocidal actions.

Benzoic acid is used to acidify the urine. An acidic urine is required to hydrolyze methenamine to ammonia and formaldehyde, which produces the bactericidal activity.

Atropine and hyoscyamine produce an antispasmodic effect, and methylene blue possesses weak antiseptic activity.

Phenyl salicylate provides mild analgesia. These combination products have been available on the market since before 1962, which is when Congress passed the amended Federal Food, Drug, and Cosmetic Act requiring that the FDA establish both safety and efficacy for all subsequently approved drugs.

Thus, these products are unapproved marketed drugs that have not been formally evaluated by the FDA for clinical safety and efficacy.

Indications

  • urinary acidification
  • urinary tract infection (UTI)

For the relief of discomfort associated with lower urinary tract infection (UTI) or diagnostic procedures by producing urinary acidification, reducing bacteriuria, and reducing spasmodic activity

Side Effects

  1. agitation
  2. anaphylactoid reactions
  3. angioedema
  4. blurred vision
  5. confusion
  6. constipation
  7. dizziness
  8. drowsiness
  9. dyspnea
  10. flushing
  11. nausea
  12. pruritus
  13. rash
  14. sinus tachycardia
  15. stool discoloration
  16. urinary retention
  17. urine discoloration
  18. vomiting
  19. xerostomia

Monitoring Parameters

  • serum creatinine/BUN
  • urinalysis

Contraindications

  • anticholinergic medications
  • anuria
  • benzoic acid hypersensitivity
  • bladder obstruction
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • coronary artery disease
  • dehydration
  • dementia
  • esophagitis
  • formaldehyde hypersensitivity
  • gastritis
  • geriatric
  • GI bleeding
  • GI obstruction
  • glaucoma
  • heart failure
  • hepatic disease
  • ileus
  • infants
  • labor
  • mitral stenosis
  • myasthenia gravis
  • neonates
  • oliguria
  • peptic ulcer disease
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • salicylate hypersensitivity
  • urinary retention
  • urinary tract obstruction

Interactions

  • Abatacept
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
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  • Acetaminophen; Pseudoephedrine
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