Aminocaproic Acid

Aminocaproic Acid Brand Name– Amicar

What is Aminocaproic Acid

Aminocaproic acid is an oral and parenteral inhibitor of fibrinolysis. It is indicated for enhancing hemostasis when fibrinolysis contributes to bleeding, in conditions such as aplastic anemia, abruptio placentae, hepatic cirrhosis, neoplastic disease, and in surgical complications after cardiac surgery and portavacal shunt.

Do not administer aminocaproic acid without a definite diagnosis and/or laboratory finding indicative for hyperfibrinolysis or if there is evidence of an active intravascular clotting process.

Aminocaproic acid use may theoretically result in clotting or thrombosis. However, there is no direct evidence that aminocaproic acid use has been responsible for the few reported cases of intravascular clotting after treatment.

Rather, it appears that such intravascular clotting was most likely attributable to the patient’s preexisting clinical condition, such as disseminated intravascular coagulation (DIC).

Indications

  1. angioedema prophylaxis
  2. dental bleeding
  3. hemorrhage
  4. hemorrhagic cystitis
  5. hyperfibrinolysis
  6. hyphema
  7. intracranial rebleeding prophylaxis
  8. subarachnoid hemorrhage
  9. surgical bleeding prophylaxis

For the treatment of hemorrhage caused by hyperfibrinolysis

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. arrhythmia exacerbation
  5. bradycardia
  6. confusion
  7. delirium
  8. diarrhea
  9. dizziness
  10. dyspnea
  11. edema
  12. ejaculation dysfunction
  13. fatigue
  14. hallucinations
  15. headache
  16. hypotension
  17. increased intracranial pressure
  18. injection site reaction
  19. leukopenia
  20. malaise
  21. myalgia
  22. myoglobinuria
  23. myopathy
  24. nasal congestion
  25. nausea
  26. phlebitis
  27. pruritus
  28. pulmonary embolism
  29. rash
  30. renal failure (unspecified)
  31. rhabdomyolysis
  32. seizures
  33. skin necrosis
  34. stroke
  35. syncope
  36. thrombocytopenia
  37. thrombosis
  38. tinnitus
  39. visual impairment
  40. vomiting
  41. weakness

Monitoring Parameters

  • creatine phosphokinase (CPK)

Contraindications

  • breast-feeding
  • disseminated intravascular coagulation (DIC)
  • hematuria
  • laboratory test interference
  • pregnancy

Interactions

  • Anti-inhibitor Coagulant Complex
  • Factor IX
  • Prothrombin Complex Concentrate, Human
  • Thrombolytic Agents
  • Tretinoin, ATRA
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