Atropine Difenoxin

Atropine Difenoxin Brand Name– Motofen

What is Atropine Difenoxin

Atropine difenoxin (Motofen) is an orally administered antidiarrheal agent.

It contains difenoxin hydrochloride, a synthetic opiate agonist that is the principal active metabolite of diphenoxylate; it has a chemical structure similar to that of meperidine.

The product formulation contains small quantities of atropine to discourage deliberate abuse or overdosage of difenoxin.

Motofen is indicated as adjunctive therapy in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.

Motofen was approved by the FDA in July 1978.

Indications

  • diarrhea

For adjunctive treatment in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. anorexia
  4. blurred vision
  5. confusion
  6. constipation
  7. depression
  8. dizziness
  9. drowsiness
  10. euphoria
  11. fatigue
  12. flushing
  13. headache
  14. hyperthermia
  15. ileus
  16. insomnia
  17. nausea
  18. ocular pruritus
  19. pancreatitis
  20. pruritus
  21. respiratory depression
  22. sinus tachycardia
  23. toxic megacolon
  24. urinary retention
  25. urticaria
  26. vomiting
  27. xerosis
  28. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticholinergic medications
  • breast-feeding
  • children
  • dehydration
  • Down’s syndrome
  • driving or operating machinery
  • electrolyte imbalance
  • gastroenteritis
  • geriatric
  • hepatic disease
  • infants
  • infection
  • jaundice
  • MAOI therapy
  • neonates
  • potential for overdose or poisoning
  • pregnancy
  • pseudomembranous colitis
  • substance abuse
  • ulcerative colitis

Interactions

  • Abatacept
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Alosetron
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Ambenonium Chloride
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Antacids
  • Anxiolytics; Sedatives; and Hypnotics
  • Apraclonidine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Oxycodone
  • Atomoxetine
  • Atracurium
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzonatate
  • Bethanechol
  • Bisacodyl
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Botulinum Toxins
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Phosphate, Supersaturated
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Carisoprodol
  • Castor Oil
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cholinergic agonists
  • Cisapride
  • Cisatracurium
  • Citalopram
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Clemastine
  • Clobazam
  • Clomipramine
  • Clonidine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colesevelam
  • COMT inhibitors
  • Crofelemer
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dantrolene
  • Darifenacin
  • Desipramine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Docusate Sodium; Senna
  • Donepezil
  • Donepezil; Memantine
  • Doxacurium
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Edrophonium
  • Eluxadoline
  • Entacapone
  • Ephedrine
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Ethotoin
  • Etomidate
  • Ezogabine
  • Fentanyl
  • Fesoterodine
  • Fexofenadine; Pseudoephedrine
  • Flavoxate
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluticasone; Umeclidinium; Vilanterol
  • food
  • Fosphenytoin
  • Gabapentin
  • Galantamine
  • Glucagon
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Glycopyrronium
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Potassium Guaiacolsulfonate
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Haloperidol
  • Hetastarch; Dextrose; Electrolytes
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Imipramine
  • Indacaterol; Glycopyrrolate
  • Iodine; Potassium Iodide, KI
  • Ipratropium
  • Itraconazole
  • Ketamine
  • Lactulose
  • Lasmiditan
  • Laxatives
  • Lemborexant
  • Levocetirizine
  • Levodopa
  • Levorphanol
  • Linaclotide
  • Linezolid
  • Lofexidine
  • Loperamide
  • Loperamide; Simethicone
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lubiprostone
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
  • Maprotiline
  • Meclizine
  • Memantine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methacholine
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methohexital
  • Methscopolamine
  • Methylcellulose
  • Methyldopa
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Mineral Oil
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Mivacurium
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Naloxone
  • Naltrexone
  • Naproxen; Pseudoephedrine
  • Neostigmine
  • Neuromuscular blockers
  • Nitrofurantoin
  • Norepinephrine
  • Nortriptyline
  • Octreotide
  • Olanzapine
  • Omeprazole; Sodium Bicarbonate
  • Opiate Agonists
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Pancuronium
  • Papaverine
  • Paroxetine
  • Pegvisomant
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Physostigmine
  • Pimozide
  • Polyethylene Glycol
  • Polyethylene Glycol; Electrolytes
  • Polyethylene Glycol; Electrolytes; Ascorbic Acid
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Potassium
  • Potassium Acetate
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium Gluconate
  • Potassium Iodide, KI
  • Pramipexole
  • Pramlintide
  • Pregabalin
  • Primidone
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propoxyphene
  • Proton pump inhibitors
  • Protriptyline
  • Pseudoephedrine
  • Psyllium
  • Pyridostigmine
  • Quetiapine
  • Quinidine
  • Rapacuronium
  • Rasagiline
  • Remifentanil
  • Revefenacin
  • Risperidone
  • Ritodrine
  • Rivastigmine
  • Rocuronium
  • Secobarbital
  • Secretin
  • Sedating H1-blockers
  • Senna
  • Sildenafil
  • Sincalide
  • Sodium Bicarbonate
  • Sodium Oxybate
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Solifenacin
  • Sorbitol
  • Succinylcholine
  • Sufentanil
  • Tacrine
  • Tapentadol
  • Tegaserod
  • Tetrabenazine
  • Thiazide diuretics
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tiotropium
  • Tiotropium; Olodaterol
  • Tolcapone
  • Tolterodine
  • Topiramate
  • Tramadol
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Trospium
  • Tubocurarine
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Vecuronium
  • Zaleplon
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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