Atropine

Atropine Brand Names

Atreza | Atropine Care | Atropisol | Isopto Atropine | Ocu-Tropine | Sal-Tropine

What is Atropine

Atropine is a naturally occurring tertiary amine extracted from belladonna alkaloid that consists of a racemic mixture of both d- and l-hyoscyamine, which differ in their antimuscarinic potencies.

Atropine is the prototype antimuscarinic from which other antimuscarinic agents were developed. Atropine counteracts cholinergic-mediated reductions in heart rate, vascular resistance, and blood pressure.

It has many applications in clinical medicine but most commonly is used systemically to treat symptomatic bradycardia and as a preoperative agent to reduce secretions prior to surgery.

Atropine is recommended as a first-line therapy for acute symptomatic bradycardia, including atrioventricular block; it is more likely to be useful for atrioventricular block at the atrioventricular nodal level and bradycardia attributable to excess vagal tone.

Atropine is also used to produce mydriasis during ophthalmic examination.

It decreases the muscarinic cholinergic adverse reactions associated with organophosphate toxicity (e.g., lacrimation, sweating, breathing problems, bradycardia) and is well known as a useful adjunct in nerve agent and insecticide poisoning.

Indications

  1. amblyopia
  2. aspiration prophylaxis
  3. beta-blocker toxicity
  4. bradycardia
  5. calcium-channel blocker toxicity
  6. cardiac arrest
  7. cholinesterase inhibitor-induced muscarinic effects prophylaxis
  8. cycloplegia induction
  9. irinotecan-induced diarrhea
  10. iritis
  11. irritable bowel syndrome
  12. mydriasis induction
  13. organophosphate insecticide toxicity
  14. rapid-sequence intubation
  15. uveitis
  • Patients with known coronary artery disease dosing: limit the total dose of parenteral atropine to 0.03 to 0.04 mg/kg.

Side Effects

  1. abdominal pain
  2. agitation
  3. amnesia
  4. anaphylactic shock
  5. angina
  6. anxiety
  7. asystole
  8. ataxia
  9. atopic dermatitis
  10. atrial fibrillation
  11. blepharitis
  12. blurred vision
  13. bradycardia
  14. coma
  15. confusion
  16. constipation
  17. cycloplegia
  18. dehydration
  19. delirium
  20. dizziness
  21. drowsiness
  22. dysarthria
  23. dysphagia
  24. fever
  25. flushing
  26. hallucinations
  27. headache
  28. hyperreflexia
  29. hypersalivation
  30. hypertension
  31. hypertonia
  32. hypotension
  33. ileus
  34. injection site reaction
  35. insomnia
  36. laryngitis
  37. laryngospasm
  38. leukocytosis
  39. maculopapular rash
  40. mania
  41. mydriasis
  42. nasal dryness
  43. nausea
  44. oral ulceration
  45. palpitations
  46. paranoia
  47. petechiae
  48. photophobia
  49. premature ventricular contractions (PVCs)
  50. pulmonary edema
  51. QT prolongation
  52. respiratory arrest
  53. respiratory depression
  54. restlessness
  55. seizures
  56. sinus tachycardia
  57. ST-T wave changes
  58. Stevens-Johnson syndrome
  59. supraventricular tachycardia (SVT)
  60. syncope
  61. tachypnea
  62. urinary incontinence
  63. urinary retention
  64. urinary urgency
  65. urticaria
  66. ventricular fibrillation
  67. vertigo
  68. vomiting
  69. weakness
  70. xerophthalmia
  71. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • achalasia
  • acute myocardial infarction
  • ambient temperature increase
  • angina
  • anticholinergic medications
  • asthma
  • autonomic neuropathy
  • bladder obstruction
  • bleeding
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • chronic lung disease (CLD)
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • colostomy
  • contact lenses
  • coronary artery disease
  • dehydration
  • dental disease
  • diarrhea
  • driving or operating machinery
  • esophagitis
  • fever
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI disease
  • GI obstruction
  • glaucoma
  • heart failure
  • heart transplant
  • hepatic disease
  • hiatal hernia
  • hypertension
  • hyperthyroidism
  • ileostomy
  • ileus
  • increased intraocular pressure
  • infants
  • mitral stenosis
  • myasthenia gravis
  • myocardial infarction
  • neonates
  • peptic ulcer disease
  • pregnancy
  • prostatic hypertrophy
  • pseudomembranous colitis
  • pyloric stenosis
  • renal failure
  • renal impairment
  • respiratory infection
  • strenuous exercise
  • synechia
  • tachycardia
  • thyrotoxicosis
  • toxic megacolon
  • ulcerative colitis
  • urinary retention
  • urinary tract obstruction

Interactions

  • Abatacept
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albuterol; Ipratropium
  • Alfentanil
  • Alosetron
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Ambenonium Chloride
  • Amoxapine
  • Antacids
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Oxycodone
  • Atomoxetine
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Botulinum Toxins
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Butorphanol
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Cholinergic agonists
  • Cisapride
  • Clemastine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colesevelam
  • Crofelemer
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Edrophonium
  • Eluxadoline
  • Ephedrine
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Ezogabine
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluticasone; Umeclidinium; Vilanterol
  • food
  • Gabapentin
  • Galantamine
  • Glucagon
  • Glycopyrronium
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Ipratropium
  • Itraconazole
  • Lasmiditan
  • Levocetirizine
  • Levodopa
  • Levorphanol
  • Linaclotide
  • Lofexidine
  • Loperamide
  • Loperamide; Simethicone
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lubiprostone
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Hydroxide
  • Maprotiline
  • Meclizine
  • Memantine
  • Meperidine
  • Meperidine; Promethazine
  • Methacholine
  • Methadone
  • Metoclopramide
  • Mirtazapine
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Naproxen; Pseudoephedrine
  • Neostigmine
  • Nitrofurantoin
  • Norepinephrine
  • Olanzapine
  • Omeprazole; Sodium Bicarbonate
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Physostigmine
  • Potassium
  • Pramlintide
  • Pregabalin
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Proton pump inhibitors
  • Pseudoephedrine
  • Pyridostigmine
  • Quetiapine
  • Quinidine
  • Rasagiline
  • Remifentanil
  • Revefenacin
  • Ritodrine
  • Rivastigmine
  • Secretin
  • Sedating H1-blockers
  • Sincalide
  • Sodium Bicarbonate
  • Solifenacin
  • Sufentanil
  • Tacrine
  • Tapentadol
  • Tegaserod
  • Thiazide diuretics
  • Thioridazine
  • Thiothixene
  • Tiotropium
  • Tiotropium; Olodaterol
  • Tolterodine
  • Topiramate
  • Tramadol
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Triprolidine
  • Trospium
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Zonisamide
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top