Aspirin Citric Acid Sodium Bicarbonate

Aspirin Citric Acid Sodium Bicarbonate Brand Names

Alka-Seltzer | Alka-Seltzer Extra Strength | Pain Relief Effervescent

What is Aspirin Citric Acid Sodium Bicarbonate

Aspirin citric acid sodium bicarbonate are used together in an oral preparation for the temporary relief of dyspepsia, minor aches and pains, myalgia, or headache.

Acetylsalicylic acid (aspirin) possesses antiinflammatory, antipyretic, and analgesic properties.

The antiinflammatory and analgesic effects of aspirin are related to irreversible inhibition of platelet cyclooxygenase, thereby decreasing synthesis of prostaglandins.

When these products are dissolved in water, aspirin is converted into its soluble ionic form, sodium acetylsalicylate, and citric acid forms sodium citrate which neutralizes stomach acid.

Sodium bicarbonate reacts with and neutralizes hydrochloric acid in the stomach; sodium chloride, water, and carbon dioxide are produced during this chemical reaction.

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. anaphylactoid reactions
  5. angioedema
  6. aplastic anemia
  7. azotemia
  8. bleeding
  9. bronchospasm
  10. confusion
  11. constipation
  12. dehydration
  13. diaphoresis
  14. diarrhea
  15. disseminated intravascular coagulation (DIC)
  16. dizziness
  17. drowsiness
  18. dyspepsia
  19. dysphagia
  20. epistaxis
  21. erythema nodosum
  22. esophageal stricture
  23. esophageal ulceration
  24. esophagitis
  25. fever
  26. gastritis
  27. GI bleeding
  28. hallucinations
  29. headache
  30. hearing loss
  31. hematoma
  32. hemolytic anemia
  33. hemorrhoids
  34. hepatic encephalopathy
  35. hepatic necrosis
  36. hepatitis
  37. hyperbilirubinemia
  38. hyperglycemia
  39. hypernatremia
  40. hyperuricemia
  41. hyperventilation
  42. hypoglycemia
  43. hypokalemia
  44. hypoprothrombinemia
  45. interstitial nephritis
  46. intracranial bleeding
  47. jaundice
  48. laryngeal edema
  49. leukocytosis
  50. leukopenia
  51. maculopapular rash
  52. melena
  53. metabolic acidosis
  54. nausea
  55. odynophagia
  56. pancytopenia
  57. peptic ulcer
  58. platelet dysfunction
  59. prolonged bleeding time
  60. pulmonary edema
  61. purpura
  62. pyrosis (heartburn)
  63. renal failure (unspecified)
  64. renal papillary necrosis
  65. renal tubular necrosis
  66. respiratory depression
  67. Reye’s syndrome
  68. seizures
  69. Stevens-Johnson syndrome
  70. thrombocytopenia
  71. tinnitus
  72. toxic epidermal necrolysis
  73. urticaria
  74. visual impairment
  75. wheezing

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • acid/base imbalance
  • acute bronchospasm
  • agranulocytosis
  • alcoholism
  • aneurysm
  • anticoagulant therapy
  • ascites
  • asthma
  • bone marrow suppression
  • breast-feeding
  • coagulopathy
  • dehydration
  • esophagitis
  • G6PD deficiency
  • gastritis
  • geriatric
  • GI bleeding
  • GI disease
  • gout
  • head trauma
  • heart failure
  • hemophilia
  • hepatic disease
  • hypertension
  • hypoprothrombinemia
  • hypovolemia
  • immunosuppression
  • increased intracranial pressure
  • influenza
  • intracranial bleeding
  • intramuscular injections
  • iron-deficiency anemia
  • labor
  • metabolic acidosis
  • metabolic alkalosis
  • nasal polyps
  • neonates
  • neutropenia
  • obstetric delivery
  • peptic ulcer disease
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • respiratory acidosis
  • respiratory alkalosis
  • Reye’s syndrome
  • salicylate hypersensitivity
  • surgery
  • systemic lupus erythematosus (SLE)
  • thrombocytopenia
  • thrombolytic therapy
  • thrombotic thrombocytopenic purpura (TTP)
  • tobacco smoking
  • urticaria
  • varicella
  • viral infection
  • vitamin K deficiency

Interactions

  • Abciximab
  • Acalabrutinib
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Acidifying Agents
  • Acrivastine; Pseudoephedrine
  • Ado-Trastuzumab emtansine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminoglycosides
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxicillin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amoxicillin; Clavulanic Acid
  • Amphetamines
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Ampicillin
  • Ampicillin; Sulbactam
  • Anagrelide
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Antithrombin III
  • Antithymocyte Globulin
  • Apixaban
  • Ardeparin
  • Ascorbic Acid, Vitamin C
  • Aspirin, ASA; Dipyridamole
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Bacitracin
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Beta-blockers
  • Betrixaban
  • Bisacodyl
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bisphosphonates
  • Bosutinib
  • Bromocriptine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Buspirone
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Capreomycin
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbenicillin
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cefditoren
  • Cefixime
  • Cefotetan
  • Cefpodoxime
  • Cefuroxime
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Chromium
  • Cidofovir
  • Cilostazol
  • Ciprofloxacin
  • Citalopram
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Citric Acid; Sodium Citrate
  • Clomipramine
  • Clopidogrel
  • Colchicine
  • Colchicine; Probenecid
  • Colistimethate, Colistin, Polymyxin E
  • Collagenase
  • Corticosteroids
  • Cyclosporine
  • Cysteamine
  • Dabigatran
  • Dabrafenib
  • Dalteparin
  • Danazol
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Deferasirox
  • Defibrotide
  • Delavirdine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dichlorphenamide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicloxacillin
  • Dicyclomine
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Dirithromycin
  • Dolutegravir; Rilpivirine
  • Donepezil; Memantine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Drotrecogin Alfa
  • Edoxaban
  • Efalizumab
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eltrombopag
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enoxaparin
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Erlotinib
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Escitalopram
  • Esomeprazole; Naproxen
  • Ethacrynic Acid
  • Ethanol
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethotoin
  • Etodolac
  • Ezetimibe
  • Ezetimibe; Simvastatin
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
  • Flavoxate
  • Flecainide
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • food
  • Fosamprenavir
  • Foscarnet
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Furosemide
  • Gabapentin
  • Gallium Ga 68 Dotatate
  • Garlic, Allium sativum
  • Gastrointestinal Enzymes
  • Gefitinib
  • Ginger, Zingiber officinale
  • Ginkgo, Ginkgo biloba
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Griseofulvin
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Halofantrine
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxychloroquine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Ibrutinib
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloprost
  • Immune Globulin IV, IVIG, IGIV
  • Incretin Mimetics
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Indomethacin
  • Inotersen
  • Insulins
  • Intravenous Lipid Emulsions
  • Iron
  • Iron Salts
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lactulose
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole; Naproxen
  • Ledipasvir; Sofosbuvir
  • Lesinurad
  • Lesinurad; Allopurinol
  • Linagliptin
  • Linagliptin; Metformin
  • Lisinopril
  • Lithium
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Low Molecular Weight Heparins
  • Macimorelin
  • Magnesium Salicylate
  • Mannitol
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Mefloquine
  • Meglitinides
  • Meloxicam
  • Memantine
  • Mepenzolate
  • Mesalamine, 5-ASA
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methazolamide
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methotrexate
  • Methscopolamine
  • Methyclothiazide
  • Methylphenidate
  • Methylsulfonylmethane, MSM
  • Metoclopramide
  • Metolazone
  • Mexiletine
  • Moexipril
  • Muromonab-CD3
  • Mycophenolate
  • Nabumetone
  • Nafcillin
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nateglinide
  • Neratinib
  • Nilotinib
  • Nitazoxanide
  • Nitrofurantoin
  • Nitroglycerin
  • Norfloxacin
  • Omacetaxine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oxacillin
  • Oxaprozin
  • Oxybutynin
  • Pancrelipase
  • Paroxetine
  • Pazopanib
  • Penicillamine
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Penicillins
  • Pentosan
  • Pentoxifylline
  • Perindopril
  • Perindopril; Amlodipine
  • Phentermine; Topiramate
  • Phenytoin
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Photosensitizing agents (topical)
  • Pioglitazone
  • Piperacillin
  • Piperacillin; Tazobactam
  • Piroxicam
  • Pneumococcal Vaccine, Polyvalent
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Polymyxins
  • Polysaccharide-Iron Complex
  • Ponatinib
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prasugrel
  • Probenecid
  • Propantheline
  • Propranolol
  • Pseudoephedrine
  • Psyllium
  • Quinapril
  • Quinidine
  • Quinine
  • Ramipril
  • Repaglinide
  • Rifampin
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  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivaroxaban
  • Rosiglitazone
  • Rosuvastatin
  • Salicylic Acid
  • Salsalate
  • Saxagliptin
  • Scopolamine
  • Selective serotonin reuptake inhibitors
  • Serotonin norepinephrine reuptake inhibitors
  • Sertraline
  • Sibutramine
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium Bicarbonate
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium Fluoride
  • Sodium Hyaluronate, Hyaluronic Acid
  • Sodium Lactate
  • Sodium Polystyrene Sulfonate
  • Sodium Thiosulfate; Salicylic Acid
  • Sotalol
  • Spironolactone
  • Sucralfate
  • Sulfinpyrazone
  • Sulfonamides
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  • Thiothixene
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  • Ticagrelor
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  • Ticlopidine
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  • Tipranavir
  • Tirofiban
  • Tolazamide
  • Tolbutamide
  • Tolmetin
  • Topiramate
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamterene
  • Trihexyphenidyl
  • Tromethamine
  • Trospium
  • Valproic Acid, Divalproex Sodium
  • Vancomycin
  • Varicella-Zoster Virus Vaccine, Live
  • Verapamil
  • Verteporfin
  • Vilazodone
  • Vorapaxar
  • Vortioxetine
  • Warfarin
  • Zafirlukast
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