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Aspirin Citric Acid Sodium Bicarbonate Brand Names
Alka-Seltzer | Alka-Seltzer Extra Strength | Pain Relief Effervescent
What is Aspirin Citric Acid Sodium Bicarbonate
Aspirin citric acid sodium bicarbonate are used together in an oral preparation for the temporary relief of dyspepsia, minor aches and pains, myalgia, or headache.
Acetylsalicylic acid (aspirin) possesses antiinflammatory, antipyretic, and analgesic properties.
The antiinflammatory and analgesic effects of aspirin are related to irreversible inhibition of platelet cyclooxygenase, thereby decreasing synthesis of prostaglandins.
When these products are dissolved in water, aspirin is converted into its soluble ionic form, sodium acetylsalicylate, and citric acid forms sodium citrate which neutralizes stomach acid.
Sodium bicarbonate reacts with and neutralizes hydrochloric acid in the stomach; sodium chloride, water, and carbon dioxide are produced during this chemical reaction.
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactoid reactions
- angioedema
- aplastic anemia
- azotemia
- bleeding
- bronchospasm
- confusion
- constipation
- dehydration
- diaphoresis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- dyspepsia
- dysphagia
- epistaxis
- erythema nodosum
- esophageal stricture
- esophageal ulceration
- esophagitis
- fever
- gastritis
- GI bleeding
- hallucinations
- headache
- hearing loss
- hematoma
- hemolytic anemia
- hemorrhoids
- hepatic encephalopathy
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hyperglycemia
- hypernatremia
- hyperuricemia
- hyperventilation
- hypoglycemia
- hypokalemia
- hypoprothrombinemia
- interstitial nephritis
- intracranial bleeding
- jaundice
- laryngeal edema
- leukocytosis
- leukopenia
- maculopapular rash
- melena
- metabolic acidosis
- nausea
- odynophagia
- pancytopenia
- peptic ulcer
- platelet dysfunction
- prolonged bleeding time
- pulmonary edema
- purpura
- pyrosis (heartburn)
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- respiratory depression
- Reye’s syndrome
- seizures
- Stevens-Johnson syndrome
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- urticaria
- visual impairment
- wheezing
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- acid/base imbalance
- acute bronchospasm
- agranulocytosis
- alcoholism
- aneurysm
- anticoagulant therapy
- ascites
- asthma
- bone marrow suppression
- breast-feeding
- coagulopathy
- dehydration
- esophagitis
- G6PD deficiency
- gastritis
- geriatric
- GI bleeding
- GI disease
- gout
- head trauma
- heart failure
- hemophilia
- hepatic disease
- hypertension
- hypoprothrombinemia
- hypovolemia
- immunosuppression
- increased intracranial pressure
- influenza
- intracranial bleeding
- intramuscular injections
- iron-deficiency anemia
- labor
- metabolic acidosis
- metabolic alkalosis
- nasal polyps
- neonates
- neutropenia
- obstetric delivery
- peptic ulcer disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- respiratory acidosis
- respiratory alkalosis
- Reye’s syndrome
- salicylate hypersensitivity
- surgery
- systemic lupus erythematosus (SLE)
- thrombocytopenia
- thrombolytic therapy
- thrombotic thrombocytopenic purpura (TTP)
- tobacco smoking
- urticaria
- varicella
- viral infection
- vitamin K deficiency
Interactions
- Abciximab
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Acidifying Agents
- Acrivastine; Pseudoephedrine
- Ado-Trastuzumab emtansine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Amphetamines
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Ampicillin
- Ampicillin; Sulbactam
- Anagrelide
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Ardeparin
- Ascorbic Acid, Vitamin C
- Aspirin, ASA; Dipyridamole
- Atazanavir
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- Atropine
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- Azilsartan; Chlorthalidone
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- Belladonna; Opium
- Benazepril
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- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Beta-blockers
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- Bismuth Subsalicylate
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- Bisoprolol; Hydrochlorothiazide, HCTZ
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- Bosutinib
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- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
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- Calcium
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- Chloroquine
- Chlorothiazide
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Chromium
- Cidofovir
- Cilostazol
- Ciprofloxacin
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Citric Acid; Sodium Citrate
- Clomipramine
- Clopidogrel
- Colchicine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Collagenase
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- Cyclosporine
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- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deferasirox
- Defibrotide
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazepam
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dicloxacillin
- Dicyclomine
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Dirithromycin
- Dolutegravir; Rilpivirine
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Drotrecogin Alfa
- Edoxaban
- Efalizumab
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- Eltrombopag
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Ephedrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Erlotinib
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Escitalopram
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethotoin
- Etodolac
- Ezetimibe
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fenoprofen
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
- Flavoxate
- Flecainide
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- food
- Fosamprenavir
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Furosemide
- Gabapentin
- Gallium Ga 68 Dotatate
- Garlic, Allium sativum
- Gastrointestinal Enzymes
- Gefitinib
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Green Tea
- Griseofulvin
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Halofantrine
- Heparin
- Hetastarch; Dextrose; Electrolytes
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloprost
- Immune Globulin IV, IVIG, IGIV
- Incretin Mimetics
- Indacaterol; Glycopyrrolate
- Indapamide
- Indomethacin
- Inotersen
- Insulins
- Intravenous Lipid Emulsions
- Iron
- Iron Salts
- Iron Sucrose, Sucroferric Oxyhydroxide
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lactulose
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Lesinurad
- Lesinurad; Allopurinol
- Linagliptin
- Linagliptin; Metformin
- Lisinopril
- Lithium
- Loop diuretics
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Low Molecular Weight Heparins
- Macimorelin
- Magnesium Salicylate
- Mannitol
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meglitinides
- Meloxicam
- Memantine
- Mepenzolate
- Mesalamine, 5-ASA
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methazolamide
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methotrexate
- Methscopolamine
- Methyclothiazide
- Methylphenidate
- Methylsulfonylmethane, MSM
- Metoclopramide
- Metolazone
- Mexiletine
- Moexipril
- Muromonab-CD3
- Mycophenolate
- Nabumetone
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Neratinib
- Nilotinib
- Nitazoxanide
- Nitrofurantoin
- Nitroglycerin
- Norfloxacin
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxacillin
- Oxaprozin
- Oxybutynin
- Pancrelipase
- Paroxetine
- Pazopanib
- Penicillamine
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Pentosan
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phentermine; Topiramate
- Phenytoin
- Phosphorated Carbohydrate Solution
- Phosphorus
- Photosensitizing agents (topical)
- Pioglitazone
- Piperacillin
- Piperacillin; Tazobactam
- Piroxicam
- Pneumococcal Vaccine, Polyvalent
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Polymyxins
- Polysaccharide-Iron Complex
- Ponatinib
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prasugrel
- Probenecid
- Propantheline
- Propranolol
- Pseudoephedrine
- Psyllium
- Quinapril
- Quinidine
- Quinine
- Ramipril
- Repaglinide
- Rifampin
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- Ritonavir
- Rituximab; Hyaluronidase
- Rivaroxaban
- Rosiglitazone
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- Salicylic Acid
- Salsalate
- Saxagliptin
- Scopolamine
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Sibutramine
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sodium Fluoride
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Lactate
- Sodium Polystyrene Sulfonate
- Sodium Thiosulfate; Salicylic Acid
- Sotalol
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