Articaine Epinephrine

Articaine Epinephrine Brand Names- Septocaine / Zorcaine with Epinephrine

What is Articaine Epinephrine

Articaine is a short-acting local anesthetic of the amide type.

The structure of articaine is similar to other amide local anesthetics except it contains an additional ester group, which is quickly hydrolyzed by esterases. The rapid breakdown of articaine leads to a low level of systemic toxicity.

Articaine is better able to diffuse through soft tissues and bone than other local anesthetics.

Articaine without epinephrine has been shown to be as effective as lidocaine or prilocaine during intravenous regional anesthesia; although, articaine may have a faster onset of action and lower peak systemic concentrations.

The FDA approved articaine-epinephrine in May 2000 for use as a local anesthetic during dental and periodontal procedures.

Articaine is widely used in Europe for dental procedures and is available as Ultracaine(R) (articaine 5%).

Indications

  • dental anesthesia
  • infiltration anesthesia
  • local anesthesia
  • peripheral nerve block

For dental anesthesia via infiltration anesthesia or local anesthesia via peripheral nerve block

Side Effects

  1. anaphylactoid reactions
  2. anxiety
  3. arrhythmia exacerbation
  4. arthralgia
  5. asthenia
  6. back pain
  7. bleeding
  8. blurred vision
  9. bradycardia
  10. cardiac arrest
  11. confusion
  12. cough
  13. diplopia
  14. dizziness
  15. drowsiness
  16. dysgeusia
  17. dyspepsia
  18. ecchymosis
  19. edema
  20. gingivitis
  21. glossitis
  22. headache
  23. hyperesthesia
  24. hypersalivation
  25. hypertension
  26. hypoesthesia
  27. hypotension
  28. infection
  29. injection site reaction
  30. lymphadenopathy
  31. malaise
  32. methemoglobinemia
  33. migraine
  34. muscle paralysis
  35. myalgia
  36. mydriasis
  37. nausea
  38. oral ulceration
  39. otalgia
  40. palpitations
  41. paresthesias
  42. pharyngitis
  43. polydipsia
  44. pruritus
  45. ptosis
  46. rash
  47. respiratory arrest
  48. respiratory depression
  49. restlessness
  50. rhinitis
  51. seizures
  52. sinus tachycardia
  53. stomatitis
  54. syncope
  55. tinnitus
  56. tissue necrosis
  57. tremor
  58. trismus
  59. urticaria
  60. vomiting
  61. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • amide local anesthetic hypersensitivity
  • asthma
  • AV block
  • breast-feeding
  • cardiac disease
  • dehydration
  • extravasation
  • G6PD deficiency
  • geriatric
  • head and neck anesthesia
  • heart failure
  • hepatic disease
  • hypertension
  • hypotension
  • hypovolemia
  • infants
  • intraarterial administration
  • intrathecal administration
  • intravenous administration
  • labor
  • MAOI therapy
  • methemoglobinemia
  • myasthenia gravis
  • neonates
  • obstetric delivery
  • peripheral vascular disease
  • pregnancy
  • pulmonary disease
  • QT prolongation
  • shock
  • sulfite hypersensitivity

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Ambenonium Chloride
  • Ambrisentan
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amobarbital
  • Amoxapine
  • Amyl Nitrite
  • Arformoterol
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atracurium
  • Atropine; Edrophonium
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  • Budesonide; Formoterol
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  • Bupivacaine; Lidocaine
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  • Caffeine
  • Caffeine; Ergotamine
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cholinesterase inhibitors
  • Cisatracurium
  • Clonidine
  • Clozapine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Cyclophosphamide
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dapsone
  • Desmopressin
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dichlorphenamide
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Dinoprostone, Prostaglandin E2
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Donepezil
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  • Enflurane
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  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergonovine
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  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin; Sulfisoxazole
  • Esmolol
  • Etomidate
  • Exenatide
  • Fentanyl
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flutamide
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Galantamine
  • Ginger, Zingiber officinale
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  • Glimepiride; Rosiglitazone
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Halothane
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  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
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  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyurea
  • Ibuprofen; Oxycodone
  • Ifosfamide
  • Iloprost
  • Incretin Mimetics
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  • Indacaterol; Glycopyrrolate
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  • Pindolol
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  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
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  • Sulfonamides
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  • Tacrine
  • Terazosin
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  • Theophylline, Aminophylline
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  • Ziprasidone
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