Amlodipine and Benazepril Brand Name– Lotrel
What is Amlodipine and Benazepril
Amlodipine and Benazepril are used together in an oral preparation to treat hypertension.
Amlodipine is a dihydropyridine calcium channel blocker and is a potent peripheral vasodilator, similar to nifedipine and other members of the dihydropyridine class, although amlodipine has the longest half-life of the group, thus allowing for once-daily dosing.
Benazepril is an angiotensin-converting enzyme (ACE) inhibitor. Benazepril is a prodrug that is hydrolyzed by esterases to the active metabolite benazeprilat, whose long duration of action makes benazepril suitable for once-daily dosing.
Benazepril and benazeprilat lack a sulfhydryl group, which has implications for the safety profile.
Benazepril monotherapy is less effective in black hypertensive patients (a low-renin hypertensive population), and the antihypertensive effects of the combination product are primarily attributed to the amlodipine component in this population.
Compared to the same doses of benazepril and amlodipine monotherapy, Lotrel® regimens are associated with less edema and greater antihypertensive effects.
Amlodipine and benazepril (Lotrel) was approved for hypertension in 1995.
Indications
- hypertension
For the treatment of hypertension in patients who do not respond to monotherapy
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- angina
- angioedema
- anxiety
- asthenia
- azotemia
- back pain
- chest pain (unspecified)
- cholestasis
- constipation
- cough
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- edema
- elevated hepatic enzymes
- eosinophilic pneumonia
- esophagitis
- fatigue
- flushing
- gingival hyperplasia
- gout
- gynecomastia
- headache
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hot flashes
- hyperbilirubinemia
- hyperkalemia
- hyperuricemia
- hypokalemia
- hypotension
- impotence (erectile dysfunction)
- insomnia
- jaundice
- laryngeal edema
- libido decrease
- muscle cramps
- musculoskeletal pain
- myocardial infarction
- nausea
- neuritis
- neutropenia
- oliguria
- palpitations
- pancreatitis
- pemphigus
- peripheral edema
- peripheral vasodilation
- pharyngitis
- polyuria
- rash
- renal failure (unspecified)
- sinus tachycardia
- Stevens-Johnson syndrome
- teratogenesis
- thrombocytopenia
- tinnitus
- tremor
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- ACE-inhibitor induced angioedema
- acute myocardial infarction
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- aortic stenosis
- autoimmune disease
- Black patients
- bone marrow suppression
- bradycardia
- breast-feeding
- cardiogenic shock
- cardiomyopathy
- cerebrovascular disease
- collagen-vascular disease
- coronary artery disease
- dialysis
- dihydropyridine hypersensitivity
- geriatric
- heart failure
- hepatic disease
- history of angioedema
- hymenoptera venom (insect sting) allergy desensitization
- hyperkalemia
- hyponatremia
- hypotension
- hypovolemia
- immunosuppression
- low-density lipoprotein apheresis
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- scleroderma
- surgery
- systemic lupus erythematosus (SLE)
- ventricular dysfunction
Interactions
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Aliskiren
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- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
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- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
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- Amphetamine; Dextroamphetamine Salts
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- Chlorpheniramine; Codeine
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- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
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- Ethosuximide
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- Fluconazole
- Fluorescein
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- Flurbiprofen
- Flutamide
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- Fosphenytoin
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- General anesthetics
- Ginkgo, Ginkgo biloba
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- Glipizide; Metformin
- Glyburide; Metformin
- Gold
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Losartan
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- Hydrochlorothiazide, HCTZ; Olmesartan
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- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
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- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen
- Ibuprofen; Oxycodone
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- Milrinone
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