Amiloride

Amiloride Brand Name– Midamor

What is Amiloride

Amiloride is an oral potassium-sparing diuretic similar in action to triamterene. It is not a thiazide diuretic.

It is used in the treatment or prevention of hypokalemia associated with kaliuretic diuretics. It is also used in the management of edema and as an adjunct in hypertension.

Although amiloride has little antihypertensive or diuretic activity compared with other diuretics, some additive effects have been noted when it is used concurrently with the thiazide or loop diuretics.

The drug can be especially useful in patients who cannot tolerate or have been unresponsive to potassium supplements.

Amiloride was approved by the FDA in 1981.

Indications

  1. ascites
  2. edema
  3. heart failure
  4. hypertension
  5. hypokalemia

For the adjunctive treatment of heart failure edema, hypertension, or hypokalemia

Side Effects

  1. abdominal pain
  2. alopecia
  3. angina
  4. anorexia
  5. anxiety
  6. aplastic anemia
  7. arthralgia
  8. back pain
  9. bladder spasm
  10. chest pain (unspecified)
  11. confusion
  12. constipation
  13. cough
  14. depression
  15. diarrhea
  16. dizziness
  17. drowsiness
  18. dyspepsia
  19. dyspnea
  20. dysuria
  21. elevated hepatic enzymes
  22. encephalopathy
  23. flatulence
  24. GI bleeding
  25. gynecomastia
  26. headache
  27. hyperkalemia
  28. hypochloremia
  29. hyponatremia
  30. impotence (erectile dysfunction)
  31. increased urinary frequency
  32. insomnia
  33. jaundice
  34. metabolic acidosis
  35. musculoskeletal pain
  36. myalgia
  37. nasal congestion
  38. nausea
  39. neutropenia
  40. orthostatic hypotension
  41. palpitations
  42. peptic ulcer
  43. polyuria
  44. pruritus
  45. rash
  46. tinnitus
  47. tremor
  48. vertigo
  49. visual impairment
  50. vomiting
  51. weakness
  52. xerostomia

Monitoring Parameters

  • serum creatinine/BUN
  • serum electrolytes

Contraindications

  • acid/base imbalance
  • anuria
  • breast-feeding
  • children
  • diabetes mellitus
  • diabetic nephropathy
  • geriatric
  • hepatic disease
  • hyperkalemia
  • hyponatremia
  • metabolic acidosis
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • respiratory acidosis

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Abacavir; Lamivudine, 3TC
  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Adefovir
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  • Alemtuzumab
  • Alfentanil
  • Aliskiren
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  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alprostadil
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  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Ambrisentan
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  • Aminosalicylate sodium, Aminosalicylic acid
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  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
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  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
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  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
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  • Aspirin, ASA; Oxycodone
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  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
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  • Choline Salicylate; Magnesium Salicylate
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  • Fosinopril
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  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
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  • Hydrocortisone
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  • Tranylcypromine
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  • Trimethoprim
  • Trospium
  • Valsartan
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin
  • Yohimbine
  • Ziconotide
  • Ziprasidone
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