Amikacin

Amikacin Brand Names- Amikin | Amikin Pediatric | ARIKAYCE

What is Amikacin

Amikacin is an aminoglycoside antibiotic that is active against aerobic gram-negative rods. It also possesses activity against certain Mycobacterium species, but is not active against any anaerobic bacteria.

Amikacin is used as part of combination treatment for gram-negative respiratory tract, abdominal, CNS infections. It is also used as part of second-line therapy for Mycobacterium avium complex (MAC) lung disease.

Amikacin is considered to be a narrow therapeutic index drug, and therefore, serum concentration monitoring is recommended for most regimens.

The major toxicities include nephrotoxicity, ototoxicity, and neurotoxicity. Amikacin liposome inhalation therapy is associated with an increased risk of respiratory adverse reactions that have led to hospitalizations in some cases.

Indications

  1. Acinetobacter sp.
  2. actinomycotic mycetoma
  3. Aeromonas sp.
  4. Bacillus anthracis
  5. bacteremia
  6. bone and joint infections
  7. burn wound infection
  8. cellulitis
  9. Citrobacter freundii
  10. Citrobacter sp.
  11. community-acquired pneumonia
  12. cystic fibrosis
  13. endocarditis
  14. Enterobacter sp.
  15. Escherichia coli
  16. febrile neutropenia
  17. Haemophilus influenzae (beta-lactamase negative)
  18. Haemophilus influenzae (beta-lactamase positive)
  19. infectious arthritis
  20. intraabdominal infections
  21. Klebsiella sp.
  22. lower respiratory tract infections
  23. meningitis
  24. Morganella sp.
  25. Mycobacterium avium
  26. Mycobacterium avium complex infection
  27. Mycobacterium fortuitum
  28. Mycobacterium intracellulare
  29. Mycobacterium tuberculosis
  30. Nocardia sp.
  31. nocardiosis
  32. nosocomial pneumonia
  33. osteomyelitis
  34. peritonitis
  35. pneumonia
  36. Proteus sp.
  37. Providencia rettgeri
  38. Providencia sp.
  39. Providencia stuartii
  40. Pseudomonas aeruginosa
  41. Pseudomonas sp.
  42. pyelonephritis
  43. Salmonella sp.
  44. sepsis
  45. Serratia marcescens
  46. Serratia sp.
  47. Shigella sp.
  48. skin and skin structure infections
  49. Staphylococcus sp.
  50. tuberculosis infection
  51. urinary tract infection (UTI)
  52. ventriculitis

Side Effects

  1. anaphylactoid reactions
  2. anemia
  3. anxiety
  4. aphonia
  5. apnea
  6. arthralgia
  7. asthenia
  8. azotemia
  9. back pain
  10. bronchospasm
  11. candidiasis
  12. cough
  13. cylindruria
  14. diarrhea
  15. dizziness
  16. dysgeusia
  17. dysphonia
  18. dyspnea
  19. encephalopathy
  20. eosinophilia
  21. epistaxis
  22. fatigue
  23. fever
  24. headache
  25. hearing loss
  26. hemoptysis
  27. hyposthenuria
  28. hypotension
  29. infection
  30. injection site reaction
  31. interstitial lung disease
  32. laryngitis
  33. maculopapular rash
  34. myalgia
  35. myasthenia
  36. nausea
  37. nephrotoxicity
  38. neurotoxicity
  39. ototoxicity
  40. paresthesias
  41. peripheral neuropathy
  42. pneumonitis
  43. pneumothorax
  44. proteinuria
  45. pseudomembranous colitis
  46. pyuria
  47. rash
  48. renal tubular acidosis (RTA)
  49. renal tubular necrosis
  50. seizures
  51. superinfection
  52. tetany
  53. throat irritation
  54. tinnitus
  55. urticaria
  56. vertigo
  57. vitamin B12 deficiency
  58. vitamin B6 deficiency
  59. vomiting
  60. weakness
  61. weight loss
  62. wheezing
  63. xerostomia

Monitoring Parameters

  • audiometry
  • serum aminoglycoside concentrations
  • serum creatinine/BUN

Contraindications

  • acute bronchospasm
  • aminoglycoside hypersensitivity
  • asthma
  • botulism
  • breast-feeding
  • chronic obstructive pulmonary disease (COPD)
  • dehydration
  • diarrhea
  • electrolyte imbalance
  • geriatric
  • GI disease
  • hearing impairment
  • inflammatory bowel disease
  • myasthenia gravis
  • neonates
  • nephrotoxicity
  • neuromuscular blockade
  • neuromuscular disease
  • neurotoxicity
  • ototoxicity
  • parkinsonism
  • pregnancy
  • premature neonates
  • pseudomembranous colitis
  • pulmonary disease
  • renal disease
  • renal failure
  • renal impairment
  • respiratory depression
  • respiratory insufficiency
  • tinnitus
  • ulcerative colitis

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Diphenhydramine
  • Acyclovir
  • Adefovir
  • Aldesleukin, IL-2
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Celecoxib
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Aprotinin
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Bacitracin
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Beractant
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bleomycin
  • Botulinum Toxins
  • Bumetanide
  • Calfactant
  • Capreomycin
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carboplatin
  • Cefepime
  • Cefotaxime
  • Cefotetan
  • Cefoxitin
  • Cefprozil
  • Ceftazidime
  • Ceftazidime; Avibactam
  • Ceftizoxime
  • Cefuroxime
  • Celecoxib
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Choline Salicylate; Magnesium Salicylate
  • Cidofovir
  • Cisatracurium
  • Cisplatin
  • Clofarabine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colfosceril; Cetyl Alcohol; Tyloxapol
  • Cyclizine
  • Cyclosporine
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Deferasirox
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxacurium
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enflurane
  • Entecavir
  • Esomeprazole; Naproxen
  • Ethacrynic Acid
  • Etodolac
  • Etomidate
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fluphenazine
  • Flurbiprofen
  • Foscarnet
  • Furosemide
  • Gallium
  • Gallium Ga 68 Dotatate
  • Ganciclovir
  • Ginger, Zingiber officinale
  • Gold
  • Halothane
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydrocodone; Ibuprofen
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibandronate
  • Ibuprofen
  • Ibuprofen lysine
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Immune Globulin IV, IVIG, IGIV
  • Indomethacin
  • Inotersen
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Isoflurane
  • Isosulfan Blue
  • Ketamine
  • Ketoprofen
  • Ketorolac
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole; Naproxen
  • Magnesium Salicylate
  • Mannitol
  • Meclizine
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Meperidine; Promethazine
  • Mesoridazine
  • Methohexital
  • Mivacurium
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Neuromuscular blockers
  • Non-Ionic Contrast Media
  • Nonsteroidal antiinflammatory drugs
  • Oral Contraceptives
  • Oxaprozin
  • Pamidronate
  • Pancuronium
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenylephrine; Promethazine
  • Piroxicam
  • Polymyxin B
  • Polymyxins
  • Poractant Alfa
  • Promethazine
  • Propofol
  • Pyridostigmine
  • Rapacuronium
  • Rocuronium
  • Rofecoxib
  • Salicylates
  • Salsalate
  • Scopolamine
  • Sevoflurane
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptozocin
  • Succinylcholine
  • Sulindac
  • Surfactants
  • Tacrolimus
  • Telavancin
  • Telbivudine
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Thioridazine
  • Tolmetin
  • Torsemide
  • Trifluoperazine
  • Trimethobenzamide
  • Tubocurarine
  • Urea
  • Valacyclovir
  • Valdecoxib
  • Valganciclovir
  • Vancomycin
  • Vecuronium
  • Warfarin
  • Zalcitabine, ddC
  • Zoledronic Acid
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