Amifampridine

Amifampridine Brand Names- FIRDAPSE | Ruzurgi

What is Amifampridine

Amifampridine is an oral aminopyridine potassium channel blocker used for the treatment of Lambert-Eaton myasthenic syndrome (LEMS).

During 2 double-blind, placebo-controlled discontinuation studies (n = 64), adult patients with LEMS randomized to placebo had statistically significantly greater worsening of muscular weakness according to Quantitative Myasthenia Gravis score change from baseline (amifampridine-placebo treatment difference least squares mean -1.7 [95% CI -3.4, 0]; p = 0.045 and -6.54 [95% CI -9.78, -3.29]; p = 0.0004).

Patients receiving placebo also had significant worsening of their impression of treatment effects on their well-being according to Subject Global Impression (SGI) score change from baseline vs. amifampridine.

The most common adverse reactions experienced by pediatric and adult patients include paresthesia, abdominal pain, dizziness, and nausea.

Seizures have been observed in patients taking amifampridine, and its use is contraindicated in patients with a history of seizure disorders.

Indications

  • Lambert-Eaton syndrome

Side Effects

  1. abdominal pain
  2. anemia
  3. anxiety
  4. arthralgia
  5. asthenia
  6. back pain
  7. blurred vision
  8. cataracts
  9. constipation
  10. cystitis
  11. depression
  12. diarrhea
  13. dizziness
  14. dysesthesia
  15. dyspepsia
  16. dysphagia
  17. dyspnea
  18. elevated hepatic enzymes
  19. erythema
  20. fever
  21. gastroesophageal reflux
  22. headache
  23. hypercholesterolemia
  24. hypertension
  25. hypoesthesia
  26. infection
  27. influenza
  28. insomnia
  29. lymphadenopathy
  30. muscle cramps
  31. myasthenia
  32. nausea
  33. paresthesias
  34. peripheral edema
  35. seizures
  36. weakness

Monitoring Parameters

  • neurologic function

Contraindications

  • breast-feeding
  • hepatic disease
  • poor metabolizers
  • pregnancy
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • slow acetylation

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Alfentanil
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Edrophonium
  • atypical antipsychotic
  • Azelastine; Fluticasone
  • Beclomethasone
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzphetamine
  • Betamethasone
  • Brexpiprazole
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Butorphanol
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Ciclesonide
  • Clomipramine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Cyclobenzaprine
  • Dalfampridine
  • Deflazacort
  • Desipramine
  • Dexamethasone
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Promethazine
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Donepezil
  • Donepezil; Memantine
  • Doxepin
  • Edrophonium
  • Fentanyl
  • Fludrocortisone
  • Flunisolide
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Galantamine
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Imipramine
  • Isocarboxazid
  • Levorphanol
  • Lisdexamfetamine
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Meperidine
  • Meperidine; Promethazine
  • Mesoridazine
  • Methadone
  • Methamphetamine
  • Methylphenidate
  • Methylprednisolone
  • Molindone
  • Mometasone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nalbuphine
  • Neostigmine
  • Nortriptyline
  • Olanzapine
  • Opiate Agonists
  • Opiate Agonists-Antagonists
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pentazocine
  • Pentazocine; Naloxone
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenothiazines
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Physostigmine
  • Prednisolone
  • Prednisone
  • Prochlorperazine
  • Promethazine
  • Propoxyphene
  • Protriptyline
  • Pyridostigmine
  • Quetiapine
  • Remifentanil
  • Risperidone
  • Rivastigmine
  • Selegiline
  • Sufentanil
  • Tacrine
  • Tapentadol
  • Theophylline, Aminophylline
  • Thiethylperazine
  • Thioridazine
  • Thiothixene
  • Tramadol
  • Tranylcypromine
  • Triamcinolone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Ziprasidone
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