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Alteplase Brand Names- Activase | Cathflo Activase
What is Alteplase
Alteplase is a parenteral thrombolytic agent.
Clinically, it is used for lysis of acute pulmonary thromboembolism, acute ischemic stroke, or acute coronary arterial thromboembolism associated with evolving transmural myocardial infarction.
It is also used to restore patency to an occluded intravenous catheter.
Alteplase is a recombinant form of human tissue plasminogen activator and is produced from genetically modified Chinese hamster ovary cells.
Indications
- acute myocardial infarction
- arterial thromboembolism
- deep venous thrombosis (DVT)
- intravascular catheter occlusion prophylaxis
- ischemic stroke
- occluded IV catheter
- percutaneous transluminal coronary angioplasty (PTCA)
- pleural effusion
- pleural empyema
- pulmonary embolism
For the treatment of acute myocardial infarction, including abrupt coronary occlusion during percutaneous transluminal coronary angioplasty (PTCA)
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- AV block
- bleeding
- bradycardia
- cardiac arrest
- cardiac tamponade
- cerebral edema
- cholesterol microembolization
- coma
- ecchymosis
- epistaxis
- fever
- GI bleeding
- heart failure
- hypertension
- hypotension
- infection
- intracranial bleeding
- laryngeal edema
- livedo reticularis
- myocardial infarction
- nausea
- pericardial effusion
- pericarditis
- pleural effusion
- premature ventricular contractions (PVCs)
- pulmonary edema
- rash
- renal failure (unspecified)
- retroperitoneal bleeding
- rhabdomyolysis
- seizures
- stroke
- thromboembolism
- thrombosis
- urticaria
- ventricular tachycardia
- vomiting
Monitoring Parameters
- creatine phosphokinase (CPK)
- ECG
- hemoglobin/hematocrit
- partial thromboplastin time (PTT)
- prothrombin time (PT)
- thrombin time
Contraindications
- aneurysm
- anticoagulant therapy
- arteriovenous malformation
- atrial fibrillation
- bleeding
- brain tumor
- breast-feeding
- children
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- diabetic retinopathy
- endocarditis
- geriatric
- GI bleeding
- head trauma
- hepatic disease
- hypertension
- infants
- infection
- intracranial bleeding
- intracranial mass
- intramuscular injections
- labor
- mitral stenosis
- neonates
- obstetric delivery
- organ biopsy
- peptic ulcer disease
- pericarditis
- pregnancy
- renal disease
- renal failure
- seizures
- stroke
- surgery
- thrombocytopenia
- thrombophlebitis
- thrombosis
- trauma
- venipuncture
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Alpha interferons
- Altretamine
- Aminocaproic Acid
- Aminosalicylate sodium, Aminosalicylic acid
- Anagrelide
- Antimetabolites
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Aprotinin
- Argatroban
- Arsenic Trioxide
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Betrixaban
- Bexarotene
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bivalirudin
- Chlorambucil
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Clofarabine
- Clopidogrel
- Dabigatran
- Dalteparin
- Danaparoid
- Danazol
- Defibrotide
- Denileukin Diftitox
- Desirudin
- Desvenlafaxine
- Dipyridamole
- Drotrecogin Alfa
- Duloxetine
- Edoxaban
- Enoxaparin
- Eptifibatide
- Estramustine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Folate analogs
- Fondaparinux
- Garlic, Allium sativum
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Green Tea
- Heparin
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Icosapent ethyl
- Intravenous Lipid Emulsions
- Lepirudin
- Levomilnacipran
- Lomustine, CCNU
- Magnesium Salicylate
- Methoxsalen
- Methylsulfonylmethane, MSM
- Milnacipran
- Nitroglycerin
- Nonsteroidal antiinflammatory drugs
- Pegaspargase
- Pentosan
- Photosensitizing agents (topical)
- Platelet Inhibitors
- Prasugrel
- Protein C Concentrate, Human
- Prothrombin Complex Concentrate, Human
- Rivaroxaban
- Salicylates
- Salsalate
- Selective serotonin reuptake inhibitors
- Sodium Hyaluronate, Hyaluronic Acid
- Sulfinpyrazone
- Thrombin Inhibitors
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tranexamic Acid
- Trazodone
- Tretinoin, ATRA
- Venlafaxine
- Verteporfin
- Vilazodone
- Vorapaxar
- Vorinostat
- Vortioxetine
- Warfarin
