Aliskiren and Hydrochlorothiazide

Aliskiren and Hydrochlorothiazide Brand Name– Tekturna HCT

What is Aliskiren and Hydrochlorothiazide

Aliskiren and hydrochlorothiazide are used together in an oral preparation for the treatment of hypertension.

Aliskiren is a direct renin inhibitor. Hydrochlorothiazide is a commonly used thiazide diuretic. The extent of blood pressure reduction with the combination of aliskiren and hydrochlorothiazide is additive.

The combination may be helpful in patients requiring thiazide diuretics but develop hypokalemia, in patients who experience dose-limiting adverse reactions on one of the individual components, and in patients likely to require combination therapy to achieve their blood pressure goals.

Aliskiren and hydrochlorothiazide (Tekturna HCT) was granted final FDA approval in January 2008.

Indications

• hypertension

Side Effects

1. abdominal pain
2. agranulocytosis
3. anaphylactoid reactions
4. anemia
5. angioedema
6. aplastic anemia
7. arthralgia
8. asthenia
9. azotemia
10. blurred vision
11. cough
12. diarrhea
13. dizziness
14. dyspepsia
15. elevated hepatic enzymes
16. erythema multiforme
17. exfoliative dermatitis
18. fever
19. gastroesophageal reflux
20. glycosuria
21. gout
22. headache
23. hemolytic anemia
24. hyperbilirubinemia
25. hypercalcemia
26. hypercholesterolemia
27. hyperglycemia
28. hyperkalemia
29. hypertriglyceridemia
30. hyperuricemia
31. hypochloremia
32. hypokalemia
33. hypomagnesemia
34. hyponatremia
35. hypotension
36. impotence (erectile dysfunction)
37. influenza
38. interstitial nephritis
39. jaundice
40. leukopenia
41. metabolic alkalosis
42. myopia
43. nephrolithiasis
44. ocular hypertension
45. orthostatic hypotension
46. pancreatitis
47. peripheral edema
48. photosensitivity
49. pneumonitis
50. pulmonary edema
51. purpura
52. rash
53. renal failure (unspecified)
54. restlessness
55. seizures
56. sialadenitis
57. Stevens-Johnson syndrome
58. syncope
59. teratogenesis
60. thrombocytopenia
61. toxic epidermal necrolysis
62. urticaria
63. vasculitis
64. vertigo
65. weakness
66. xanthopsia

Monitoring Parameters

• blood glucose
• blood pressure
• heart rate
• serum calcium
• serum creatinine/BUN
• serum electrolytes
• serum magnesium
• serum potassium
• serum uric acid

Contraindications

• ACE-inhibitor induced angioedema
• acid/base imbalance
• angioedema
• anuria
• aortic stenosis
• asthma
• Black patients
• breast-feeding
• cardiomyopathy
• cerebrovascular disease
• children
• coronary artery disease
• diabetes mellitus
• electrolyte imbalance
• geriatric
• gout
• heart failure
• hepatic disease
• hereditary angioedema
• hypercalcemia
• hyperkalemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• infants
• jaundice
• metabolic alkalosis
• neonates
• orthostatic hypotension
• pancreatitis
• penicillin hypersensitivity
• pregnancy
• renal artery stenosis
• renal failure
• renal impairment
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• surgery
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity

Interactions

• Acarbose
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acetohexamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alemtuzumab
• Alendronate; Cholecalciferol
• Alfentanil
• Aliskiren; Valsartan
• Allopurinol
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Alprostadil
• Amifostine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
• Amiodarone
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine; Dextroamphetamine Salts
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Amyl Nitrite
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Apraclonidine
• Aprepitant, Fosaprepitant
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atorvastatin
• Atorvastatin; Ezetimibe
• Atracurium
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Benztropine
• Beta-agonists
• Boceprevir
• Bortezomib
• Bosentan
• Brexpiprazole
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide; Formoterol
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Cabergoline
• Calcium
• Calcium Phosphate, Supersaturated
• Calcium; Vitamin D
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
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• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
• Cariprazine
• Celecoxib
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpropamide
• Cholestyramine
• Cidofovir
• Ciprofloxacin
• Cisapride
• Cisatracurium
• Citalopram
• Citric Acid; Potassium Citrate
• Citric Acid; Potassium Citrate; Sodium Citrate
• Clindamycin; Tretinoin
• Clozapine
• Co-Enzyme Q10, Ubiquinone
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine; Probenecid
• Colestipol
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• Daclatasvir
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• Darunavir
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• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Desloratadine; Pseudoephedrine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexlansoprazole
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Quinidine
• Diazoxide
• Dichlorphenamide
• Diclofenac
• Diclofenac; Misoprostol
• Dicyclomine
• Diethylpropion
• Diflunisal
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dobutamine
• Dofetilide
• Dolasetron
• Donepezil; Memantine
• Dopamine
• Doxacurium
• Dronedarone
• Droperidol
• Drospirenone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Dulaglutide
• Duloxetine
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Ephedrine
• Epinephrine
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergocalciferol, Vitamin D2
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esomeprazole
• Esomeprazole; Naproxen
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Ethacrynic Acid
• Ethanol
• Etodolac
• Etomidate
• Exenatide
• Famotidine; Ibuprofen
• Fenoldopam
• Fenoprofen
• Fentanyl
• Fexofenadine; Pseudoephedrine
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Flavoxate
• Fluconazole
• Fluocinolone; Hydroquinone; Tretinoin
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurbiprofen
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosamprenavir
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Fostamatinib
• Furosemide
• Gallium Ga 68 Dotatate
• General anesthetics
• Glecaprevir; Pibrentasvir
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Potassium Guaiacolsulfonate
• Guaifenesin; Pseudoephedrine
• Halobetasol; Tazarotene
• Halofantrine
• Haloperidol
• Halothane
• Hetastarch; Dextrose; Electrolytes
• Homatropine; Hydrocodone
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
• Ibuprofen
• Ibuprofen lysine
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Icosapent ethyl
• Idelalisib
• Iloperidone
• Iloprost
• Inamrinone
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Indomethacin
• Inotersen
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Intravenous Lipid Emulsions
• Iodine; Potassium Iodide, KI
• Irbesartan
• Isavuconazonium
• Isocarboxazid
• Isoflurane
• Isoproterenol
• Isosorbide Dinitrate, ISDN
• Isosorbide Mononitrate
• Itraconazole
• Ketamine
• Ketoconazole
• Ketoprofen
• Ketorolac
• Lansoprazole
• Lansoprazole; Naproxen
• Lesinurad
• Lesinurad; Allopurinol
• Levalbuterol
• Levodopa
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Lomitapide
• Loop diuretics
• Lopinavir; Ritonavir
• Loratadine; Pseudoephedrine
• Losartan
• Lovastatin; Niacin
• Lumacaftor; Ivacaftor
• Lurasidone
• Magnesium Salts
• Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
• Mannitol
• Meclofenamate Sodium
• Mefenamic Acid
• Meglitinides
• Meloxicam
• Memantine
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mepivacaine
• Mepivacaine; Levonordefrin
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methotrexate
• Methoxsalen
• Methscopolamine
• Methylphenidate
• Metoclopramide
• Midodrine
• Miglitol
• Milnacipran
• Milrinone
• Minoxidil
• Mirtazapine
• Mitotane
• Mivacurium
• Moexipril
• Morphine
• Morphine; Naltrexone
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Nebivolol; Valsartan
• Nefazodone
• Nesiritide, BNP
• Neuromuscular blockers
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nitrates
• Nitroglycerin
• Nitroprusside
• Nonsteroidal antiinflammatory drugs
• Norepinephrine
• Octreotide
• Olanzapine
• Olmesartan
• Olodaterol
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oprelvekin, rh-IL-11
• Oxaprozin
• Oxybutynin
• Oxycodone
• Oxymetazoline
• Oxymorphone
• Paliperidone
• Pancuronium
• Pantoprazole
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentoxifylline
• Perindopril
• Perindopril; Amlodipine
• Phendimetrazine
• Phenelzine
• Phenothiazines
• Phentermine
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
• Pimozide
• Pioglitazone
• Pirbuterol
• Piroxicam
• Polycarbophil
• Polyethylene Glycol; Electrolytes
• Polyethylene Glycol; Electrolytes; Ascorbic Acid
• Ponatinib
• Porfimer
• Posaconazole
• Potassium
• Potassium Acetate
• Potassium Bicarbonate
• Potassium Chloride
• Potassium Citrate
• Potassium Gluconate
• Potassium Iodide, KI
• Potassium-sparing diuretics
• Pramlintide
• Prazosin
• Prilocaine; Epinephrine
• Probenecid
• Procainamide
• Procaine
• Propantheline
• Propofol
• Pseudoephedrine
• Quetiapine
• Quinapril
• Quinidine
• Rabeprazole
• Ramipril
• Rapacuronium
• Rasagiline
• Remifentanil
• Repaglinide
• Risperidone
• Ritonavir
• Rocuronium
• Rofecoxib
• Rosiglitazone
• Sacubitril; Valsartan
• Salicylates
• Salmeterol
• Sapropterin
• Saxagliptin
• Scopolamine
• Selegiline
• Semaglutide
• Serotonin norepinephrine reuptake inhibitors
• Sertraline
• Sevoflurane
• Sildenafil
• Silodosin
• Simvastatin; Sitagliptin
• Sitagliptin
• Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Solifenacin
• Spironolactone
• Streptozocin
• Succinylcholine
• Sufentanil
• Sulfacetamide
• Sulfacetamide; Sulfur
• Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
• Sulfinpyrazone
• Sulfonylureas
• Sulindac
• Tapentadol
• Tazarotene
• Tegaserod
• Telaprevir
• Telmisartan
• Telotristat Ethyl
• Terbutaline
• Tetrabenazine
• Tetracaine
• Thiazolidinediones
• Thiothixene
• Tiotropium; Olodaterol
• Tizanidine
• Tolazamide
• Tolbutamide
• Tolmetin
• Tolterodine
• Tolvaptan
• Topiramate
• Toremifene
• Torsemide
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Treprostinil
• Tretinoin, ATRA
• Triamterene
• Trihexyphenidyl
• Trospium
• Tubocurarine
• Umeclidinium; Vilanterol
• Valdecoxib
• Valsartan
• Vasodilators
• Vecuronium
• Venlafaxine
• Verapamil
• Verteporfin
• Vilazodone
• Vitamin D
• Vitamin D analogs
• Vorinostat
• Vortioxetine
• Warfarin
• Yohimbine
• Ziconotide
• Ziprasidone
• Zonisamide