Aliskiren and Valsartan

Aliskiren and Valsartan Brand Name– Valturna

What is Aliskiren and Valsartan

Aliskiren and valsartan are used together in an oral preparation for the treatment of hypertension.

Aliskiren is a direct renin inhibitor; valsartan is a specific angiotensin II receptor antagonist that selectively and competitively blocks the AT-1 receptor, which mediates the vasopressor and aldosterone effects of angiotensin II. Because valsartan does not inhibit angiotensin converting enzyme (ACE), it does not result in bradykinin accumulation, which is theorized to cause the cough and angioedema associated with ACE inhibitors.

However, angioedema has been rarely associated with valsartan and other angiotensin II antagonists.

The combination may be helpful in patients not adequately controlled on monotherapy, and in patients likely to require combination therapy to achieve their blood pressure goals.

Indications

  • hypertension

For the treatment of hypertension

for initial therapy of hypertension in patients who are likely to need multiple drugs to achieve their blood pressure goals

Side Effects

  1. alopecia
  2. anaphylactoid reactions
  3. angioedema
  4. azotemia
  5. cough
  6. diarrhea
  7. dizziness
  8. elevated hepatic enzymes
  9. fatigue
  10. gout
  11. headache
  12. hepatitis
  13. hyperkalemia
  14. hypotension
  15. impotence (erectile dysfunction)
  16. infection
  17. influenza
  18. nephrolithiasis
  19. neutropenia
  20. oliguria
  21. peripheral edema
  22. pharyngitis
  23. rash
  24. renal failure (unspecified)
  25. rhabdomyolysis
  26. seizures
  27. teratogenesis
  28. thrombocytopenia
  29. vasculitis
  30. vertigo

Monitoring Parameters

  • blood pressure
  • heart rate
  • LFTs
  • serum bilirubin (total and direct)
  • serum creatinine/BUN
  • serum potassium

Contraindications

  • ACE-inhibitor induced angioedema
  • angioedema
  • aortic stenosis
  • biliary cirrhosis
  • Black patients
  • breast-feeding
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • coronary artery disease
  • diabetes mellitus
  • geriatric
  • heart failure
  • hepatic disease
  • hereditary angioedema
  • hyperkalemia
  • hypokalemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • infants
  • myocardial infarction
  • neonates
  • pregnancy
  • renal artery stenosis
  • renal failure
  • renal impairment
  • surgery

Interactions

  • Acarbose
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Alprostadil
  • Amifostine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amphetamine; Dextroamphetamine Salts
  • Amyl Nitrite
  • Angiotensin II
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Apomorphine
  • Apraclonidine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Asenapine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzphetamine
  • Boceprevir
  • Bosentan
  • Brexpiprazole
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bumetanide
  • Cabergoline
  • Calcium Phosphate, Supersaturated
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Ciprofloxacin
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Clofarabine
  • Clozapine
  • Co-Enzyme Q10, Ubiquinone
  • Cobicistat
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Cyclosporine
  • Daclatasvir
  • Dapagliflozin; Metformin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diethylpropion
  • Diflunisal
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dronedarone
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Elexacaftor; tezacaftor; ivacaftor
  • Eltrombopag
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Ephedrine
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Esomeprazole; Naproxen
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Ethacrynic Acid
  • Etodolac
  • Etomidate
  • Famotidine; Ibuprofen
  • Fenofibric Acid
  • Fenoldopam
  • Fenoprofen
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Fosamprenavir
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Fostamatinib
  • Furosemide
  • Gemfibrozil
  • General anesthetics
  • Glecaprevir; Pibrentasvir
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Potassium Guaiacolsulfonate
  • Guaifenesin; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibritumomab Tiuxetan
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Idelalisib
  • Iloperidone
  • Iloprost
  • Incretin Mimetics
  • Indapamide
  • Indomethacin
  • Insulins
  • Intravenous Lipid Emulsions
  • Iodine; Potassium Iodide, KI
  • Irbesartan
  • Isavuconazonium
  • Isocarboxazid
  • Isoflurane
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Itraconazole
  • Ketamine
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lesinurad
  • Lesinurad; Allopurinol
  • Levodopa
  • Linagliptin; Metformin
  • Lisdexamfetamine
  • Lisinopril
  • Lithium
  • Lomitapide
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Losartan
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Lurasidone
  • Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meglitinides
  • Meloxicam
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methamphetamine
  • Methohexital
  • Methylphenidate
  • Miglitol
  • Milrinone
  • Minoxidil
  • Mitotane
  • Moexipril
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nateglinide
  • Nebivolol; Valsartan
  • Nefazodone
  • Nesiritide, BNP
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Obeticholic Acid
  • Olanzapine
  • Olmesartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Oxaprozin
  • Oxymetazoline
  • Paliperidone
  • Pazopanib
  • Pentoxifylline
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Piroxicam
  • Polyethylene Glycol; Electrolytes
  • Polyethylene Glycol; Electrolytes; Ascorbic Acid
  • Ponatinib
  • Posaconazole
  • Potassium
  • Potassium Acetate
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium Gluconate
  • Potassium Iodide, KI
  • Potassium-sparing diuretics
  • Pramlintide
  • Prazosin
  • Procainamide
  • Procaine
  • Propofol
  • Pseudoephedrine
  • Quinapril
  • Quinidine
  • Ramipril
  • Rasagiline
  • Repaglinide
  • Rifampin
  • Risperidone
  • Ritonavir
  • Rofecoxib
  • Sacubitril; Valsartan
  • Sapropterin
  • Selegiline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sildenafil
  • Silodosin
  • Simeprevir
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Spironolactone
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfonylureas
  • Sulindac
  • Telaprevir
  • Telithromycin
  • Telmisartan
  • Telotristat Ethyl
  • Tetracaine
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Tizanidine
  • Tolmetin
  • Tolvaptan
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Trimethoprim
  • Tucatinib
  • Valdecoxib
  • Valsartan
  • Vasodilators
  • Verapamil
  • Warfarin
  • Yohimbine
  • Zafirlukast
  • Ziprasidone
  • Zonisamide
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