Acetaminophen Chlorpheniramine Phenylephrine Phenyltoloxamine Brand Names – Norel SR | Trital SR
What is Acetaminophen Chlorpheniramine Phenylephrine Phenyltoloxamine
Acetaminophen Chlorpheniramine Phenylephrine Phenyltoloxamine is a prescription combination product used for the temporary relief of headache, pain, nasal congestion, rhinorrhea, and sneezing associated with allergic rhinitis.
Acetaminophen possesses analgesic and antipyretic activity similar to aspirin; however, acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function.
Acetaminophen is the preferred analgesic/antipyretic for patients in whom aspirin is contraindicated (e.g., those who have a history of gastric ulcer or a coagulation disorder). In addition, acetaminophen has been recommended by the American Lung Association as the first line treatment for aches and pains associated with the flu.
Chlorpheniramine is a first generation antihistamine (H1-blocker) commonly used for treating symptoms related to histamine release such as rhinorrhea and sneezing.
Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion. Phenyltoloxamine is aa sedating antihistamine of the ethanolamine class.
Phenyltoloxamine is used in this product as an adjunct to acetaminophen for the treatment of pain. Overall, however, its use for this purpose is questionable since some data do not indicate a substantial benefit.
Acetaminophen; chlorpheniramine; phenylephrine; phenyltoloxamine is available in an extended-release tablet formulation for adults and children.
Indications
- allergic rhinitis
- headache
- mild pain
- nasal congestion
- rhinorrhea
- sneezing
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angina
- angioedema
- anorexia
- anxiety
- aplastic anemia
- arrhythmia exacerbation
- ataxia
- AV block
- bleeding
- blurred vision
- bradycardia
- bronchial secretions
- colitis
- constipation
- contact dermatitis
- dizziness
- drowsiness
- dysuria
- elevated hepatic enzymes
- encephalopathy
- erythema
- excitability
- exfoliative dermatitis
- fever
- GI bleeding
- hallucinations
- hemolysis
- hemolytic anemia
- hepatic necrosis
- hypertension
- hypoprothrombinemia
- insomnia
- interstitial nephritis
- jaundice
- lethargy
- maculopapular rash
- methemoglobinemia
- mydriasis
- myocardial infarction
- myocarditis
- nausea
- ocular hypertension
- pallor
- palpitations
- pancytopenia
- photophobia
- pruritus
- psychosis
- purpura
- rash
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- restlessness
- seizures
- sinus tachycardia
- stroke
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urinary retention
- urticaria
- vomiting
- xerophthalmia
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN: in chronic use or acute toxicity
Contraindications
- acute myocardial infarction
- alcoholism
- aneurysm
- angina
- anticholinergic medications
- arteriosclerosis
- asthma
- atrial fibrillation
- atrial flutter
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- bronchitis
- bundle-branch block
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- constipation
- contact lenses
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- emphysema
- G6PD deficiency
- geriatric
- GI disease
- GI obstruction
- heart failure
- hepatic disease
- hepatitis
- hypertension
- hyperthyroidism
- ileus
- increased intraocular pressure
- infants
- intracranial bleeding
- labor
- MAOI therapy
- myocardial infarction
- neonates
- obstetric delivery
- organic brain syndrome
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- pyloric stenosis
- renal disease
- renal failure
- renal impairment
- status asthmaticus
- stroke
- tachycardia
- thyrotoxicosis
- ulcerative colitis
- urinary retention
- ventricular fibrillation
- ventricular tachycardia
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amantadine
- Ambenonium Chloride
- Ambrisentan
- Amikacin
- Amiloride
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- Aminoglycosides
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine
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- Amphetamine; Dextroamphetamine Salts
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- Asenapine
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- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
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- Carbetapentane; Guaifenesin; Phenylephrine
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- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Carisoprodol
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Charcoal
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- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
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- Chlorthalidone; Clonidine
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- Desloratadine
- Desloratadine; Pseudoephedrine
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- Dexamethasone
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- Diazepam
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- Digoxin
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- Dyphylline; Guaifenesin
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- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
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- Felodipine
- Fentanyl
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- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Hydroxyprogesterone
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
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- Incretin Mimetics
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- Isradipine
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