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Acetaminophen Dichloralphenazone Isometheptene Brand Names
Amidrine | Diacetazone | Duradrin | I.D.A. | Midrin | Migquin | Migragesic IDA | Migratine | Migrazone | Migrin-A | Nodolor
What is Acetaminophen Dichloralphenazone Isometheptene
Acetaminophen Dichloralphenazone Isometheptene are used together in an oral preparation to treat migraine or tension-type headaches.
Acetaminophen is a non-salicylate analgesic with similar analgesic potency to NSAIDs.
Dichloralphenazone (also known as Dichloralantipyrine) is a complex of chloral hydrate and phenazone (antipyrine) and is present for its mild sedative effects and for reducing the emotional stimulation of headaches.
Isometheptene is a sympathomimetic that possesses primarily indirect alpha- and beta-adrenergic action.
Acetaminophen; dichloralphenazone; isometheptene combination products have been in use since before 1938.
Indications
- headache
- migraine
NOTE: In January 2011, the FDA mandated that all acetaminophen-containing combination prescription medications will have a maximum of 325 mg of acetaminophen per dosage unit (i.e., capsule, tablet, or other dose unit). This action has been taken to reduce the risk of liver damage and severe hypersensitivity reactions associated with acetaminophen.
Manufacturers will have 3 years to comply. In the interim, healthcare providers are encouraged to instruct patients to limit acetaminophen use to no more than 4 grams daily and to avoid alcohol while taking acetaminophen.
Further, advise patients to check all over-the-counter and prescription medications for acetaminophen content and to consult their healthcare provider with any questions.
Patients may continue current medications as prescribed and should seek medical help if excess acetaminophen is consumed or if symptoms of hypersensitivity or other adverse events occur.
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- contact dermatitis
- dizziness
- drowsiness
- elevated hepatic enzymes
- encephalopathy
- erythema
- exfoliative dermatitis
- fever
- headache
- hearing loss
- hemolysis
- hemolytic anemia
- hepatic necrosis
- hypoprothrombinemia
- interstitial nephritis
- jaundice
- maculopapular rash
- nausea
- neutropenia
- ototoxicity
- pancytopenia
- pruritus
- purpura
- rash
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombocytosis
- tolerance
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- acetaminophen hypersensitivity
- alcoholism
- anemia
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- diabetes mellitus
- driving or operating machinery
- G6PD deficiency
- geriatric
- glaucoma
- head trauma
- hepatic disease
- hepatitis
- hypertension
- immunosuppression
- infection
- MAOI therapy
- myocardial infarction
- peptic ulcer disease
- peripheral vascular disease
- porphyria
- pregnancy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- thyroid disease
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Ambrisentan
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Antacids
- Apraclonidine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Beta-blockers
- Betaxolol
- Bethanechol
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Bretylium
- Brexpiprazole
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Busulfan
- Butabarbital
- Caffeine
- Caffeine; Ergotamine
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
- Carisoprodol
- Carteolol
- Carvedilol
- Charcoal
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chloroprocaine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Clemastine
- Clobazam
- Clomipramine
- Clonidine
- Clozapine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desipramine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Diflunisal
- Digitoxin
- Digoxin
- Dimenhydrinate
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disulfiram
- Dorzolamide; Timolol
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Dyphylline
- Dyphylline; Guaifenesin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eltrombopag
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Eplerenone
- Epoprostenol
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Exenatide
- Fentanyl
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol
- Formoterol; Mometasone
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glycopyrrolate; Formoterol
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Hydroxyzine
- Iloperidone
- Iloprost
- Imatinib
- Imipramine
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Labetalol
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lanthanum Carbonate
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Lidocaine; Prilocaine
- Linezolid
- Liothyronine
- Liraglutide
- Lithium
- Lixisenatide
- Lomitapide
- Loop diuretics
- Lopinavir; Ritonavir
- Lumateperone
- Lurasidone
- Macitentan
- Magnesium Salicylate
- Maprotiline
- Mecamylamine
- Meclizine
- Meglitinides
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Metaproterenol
- Metaxalone
- Metformin; Pioglitazone
- Metformin; Rosiglitazone
- Methohexital
- Methyldopa
- Metoclopramide
- Metoprolol
- Metyrapone
- Miglitol
- Mipomersen
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Nabilone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nitrates
- Nortriptyline
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Orphenadrine
- Oxybutynin
- Ozanimod
- Paliperidone
- Penbutolol
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Pindolol
- Pioglitazone
- Pirbuterol
- Pneumococcal Vaccine, Polyvalent
- Posaconazole
- Pramipexole
- Pramlintide
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propranolol
- Protriptyline
- Quetiapine
- Rasagiline
- Reserpine
- Rifabutin
- Rifampin
- Riociguat
- Risperidone
- Ritonavir
- Ropivacaine
- Rosiglitazone
- Safinamide
- Salmeterol
- Salsalate
- Secobarbital
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selexipag
- Semaglutide
- SGLT2 Inhibitors
- Sibutramine
- Skeletal Muscle Relaxants
- Sodium Bicarbonate
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sulfinpyrazone
- Sulfonylureas
- Tapentadol
- Telaprevir
- Telotristat Ethyl
- Terbutaline
- Tetrabenazine
- Tetracaine
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Timolol
- Tizanidine
- tobacco
- Tranylcypromine
- Treprostinil
- Tricyclic antidepressants
- Trifluoperazine
- Trimetrexate
- Trimipramine
- Triprolidine
- Umeclidinium; Vilanterol
- Vasodilators
- Vemurafenib
- Vigabatrin
- Vilazodone
- Warfarin
- Zaleplon
- Ziconotide
- Zidovudine, ZDV
- Ziprasidone
- Zolmitriptan
