Acetaminophen and Butalbital

Acetaminophen and Butalbital Brand Names

Allzital | Axocet | Bucet | Bupap | Cephadyn | Dolgic | Marten | ORBIVAN CF | Phrenilin | Phrenilin Forte | Promacet | Repan CF | Sedapap | Tencon

What is Acetaminophen and Butalbital

Acetaminophen, a non-salicylate analgesic, and butalbital, a barbiturate, are used together in oral products to treat tension headaches in adult and pediatric patients 12 years of age and older, especially when antianxiety or relaxant effects are needed.

Treatment of multiple recurrent headaches with acetaminophen; butalbital has not been well studied and extended use of these products is not recommended.

No data from randomized, placebo-controlled trials to prove or refute the efficacy of acetaminophen; butalbital for the acute treatment of migraines are available.

According to published guidelines for the acute management of migraine, the use of butalbital-containing analgesics should be limited and carefully monitored due to concerns of overuse, medication-overuse headache, abuse, and withdrawal.

All acetaminophen-containing products carry a boxed warning in their prescribing information regarding the risk for hepatotoxicity, particularly with oral doses exceeding 4 grams/day.

Indications & Dosage

  • headache

General dosing information:

  • Maximum daily dosage limits for acetaminophen are based on all routes of administration (e.g., intravenous, oral, rectal) and all products containing acetaminophen, including both single-entity and combination products. Exceeding maximum daily dosage limits can result in hepatic injury, hepatic failure, and death. In an attempt to reduce the risk of hepatotoxicity, the FDA has recommended limiting the amount of acetaminophen in prescription combination products to 325 mg per dosage unit.
  • Extended use is inadvisable due to the habit-forming and abusable nature of butalbital. The safety and efficacy of acetaminophen; butalbital for multiple, recurrent headaches is not established.

Side Effects

  1. abdominal pain
  2. acneiform rash
  3. acute generalized exanthematous pustulosis (AGEP)
  4. agitation
  5. agranulocytosis
  6. anaphylactoid reactions
  7. angioedema
  8. anorexia
  9. coma
  10. confusion
  11. constipation
  12. contact dermatitis
  13. diuresis
  14. dizziness
  15. drowsiness
  16. dyspepsia
  17. dysphagia
  18. dyspnea
  19. elevated hepatic enzymes
  20. emotional lability
  21. erythema
  22. erythema multiforme
  23. euphoria
  24. exfoliative dermatitis
  25. fatigue
  26. fever
  27. flatulence
  28. headache
  29. hemolysis
  30. hemolytic anemia
  31. hepatic encephalopathy
  32. hepatic failure
  33. hepatic necrosis
  34. hepatotoxicity
  35. hot flashes
  36. hyperhidrosis
  37. hypoprothrombinemia
  38. hypotension
  39. impaired cognition
  40. increased urinary frequency
  41. interstitial nephritis
  42. jaundice
  43. lethargy
  44. maculopapular rash
  45. malaise
  46. musculoskeletal pain
  47. nasal congestion
  48. nausea
  49. neutropenia
  50. otalgia
  51. pancytopenia
  52. paresthesias
  53. photosensitivity
  54. physiological dependence
  55. pruritus
  56. psychological dependence
  57. ptosis
  58. purpura
  59. rash
  60. renal failure (unspecified)
  61. renal papillary necrosis
  62. renal tubular necrosis
  63. respiratory depression
  64. seizures
  65. sinus tachycardia
  66. Stevens-Johnson syndrome
  67. syncope
  68. thrombocytopenia
  69. thrombocytosis
  70. tinnitus
  71. tolerance
  72. toxic epidermal necrolysis
  73. urticaria
  74. vertigo
  75. vomiting
  76. withdrawal
  77. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • abrupt discontinuation
  • acetaminophen hypersensitivity
  • acute abdomen
  • agranulocytosis
  • alcoholism
  • barbiturate hypersensitivity
  • breast-feeding
  • carbamazepine hypersensitivity
  • children
  • chronic obstructive pulmonary disease (COPD)
  • CNS depression
  • coadministration with other CNS depressants
  • depression
  • driving or operating machinery
  • ethanol ingestion
  • ethanol intoxication
  • G6PD deficiency
  • geriatric
  • head trauma
  • hepatic disease
  • hepatitis
  • hepatotoxicity
  • hydantoin hypersensitivity
  • hypovolemia
  • infants
  • malnutrition
  • neonates
  • porphyria
  • potential for overdose or poisoning
  • pregnancy
  • pulmonary disease
  • renal failure
  • renal impairment
  • respiratory depression
  • sleep apnea
  • substance abuse
  • suicidal ideation

Interactions

  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Abemaciclib
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alprazolam
  • Altretamine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Anagrelide
  • Antacids
  • Apomorphine
  • Apraclonidine
  • Apremilast
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Armodafinil
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Avapritinib
  • Avatrombopag
  • Axitinib
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Barbiturates
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendamustine
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Bicalutamide
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Bortezomib
  • Brexpiprazole
  • Brigatinib
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brivaracetam
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Busulfan
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcifediol
  • Calcitriol
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capmatinib
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Cariprazine
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Cevimeline
  • Charcoal
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorambucil
  • Chloramphenicol
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroprocaine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Cinacalcet
  • Citalopram
  • Clemastine
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobimetinib
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Cyclophosphamide
  • Cyclosporine
  • Cyproheptadine
  • Dapsone
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Delavirdine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxercalciferol
  • Doxorubicin
  • Doxycycline
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eltrombopag
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encorafenib
  • Entacapone
  • Entrectinib
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erdafitinib
  • Erlotinib
  • Escitalopram
  • Esketamine
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Exenatide
  • Ezetimibe; Simvastatin
  • Fedratinib
  • Felodipine
  • Fenoprofen
  • Fentanyl
  • Flibanserin
  • Fluconazole
  • Fluoxetine; Olanzapine
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Fosamprenavir
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gabapentin
  • Galantamine
  • Gallium Ga 68 Dotatate
  • General anesthetics
  • Glasdegib
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Green Tea
  • Griseofulvin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Hemin
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyprogesterone
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ifosfamide
  • Iloperidone
  • Imatinib
  • Indinavir
  • Insulin Glargine; Lixisenatide
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ixabepilone
  • Ketoconazole
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamotrigine
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lanthanum Carbonate
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lesinurad
  • Lesinurad; Allopurinol
  • Leucovorin
  • Levobupivacaine
  • Levocetirizine
  • Levoleucovorin
  • Levorphanol
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin
  • Linagliptin; Metformin
  • Lithium
  • Lixisenatide
  • Lofexidine
  • Lomitapide
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lorlatinib
  • Lovastatin
  • Lovastatin; Niacin
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salicylate
  • Magnesium Salts
  • Mannitol
  • Maprotiline
  • Mebendazole
  • Meclizine
  • Mefloquine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Meprobamate
  • Mestranol; Norethindrone
  • Metformin; Repaglinide
  • Methadone
  • Methazolamide
  • Methocarbamol
  • Methohexital
  • Methscopolamine
  • Methsuximide
  • Methyclothiazide
  • Methylprednisolone
  • Metoclopramide
  • Metolazone
  • Metronidazole
  • Metyrapone
  • Metyrosine
  • Mexiletine
  • Midazolam
  • Minocycline
  • Mipomersen
  • Mirtazapine
  • Mitotane
  • Modafinil
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nelfinavir
  • Neratinib
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Olanzapine
  • Olaparib
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Ondansetron
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Paclitaxel
  • Paliperidone
  • Papaverine
  • Paroxetine
  • Pemigatinib
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Pimavanserin
  • Pneumococcal Vaccine, Polyvalent
  • Pomalidomide
  • Posaconazole
  • Pralidoxime
  • Pramipexole
  • Pramlintide
  • Prednisolone
  • Prednisone
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Progestins
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Red Yeast Rice
  • Remifentanil
  • Repaglinide
  • Reserpine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rilpivirine
  • Riluzole
  • Rimegepant
  • Risperidone
  • Ritonavir
  • Roflumilast
  • Romidepsin
  • Ropinirole
  • Ropivacaine
  • Rotigotine
  • Safinamide
  • Salicylates
  • Salsalate
  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Selpercatinib
  • Selumetinib
  • Sertraline
  • Sildenafil
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Siponimod
  • Sirolimus
  • Skeletal Muscle Relaxants
  • Sodium Bicarbonate
  • Sodium Oxybate
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfinpyrazone
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Telaprevir
  • Telotristat Ethyl
  • Temazepam
  • Terbinafine
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiopental
  • Thiothixene
  • Thyroid hormones
  • Tipranavir
  • Tizanidine
  • tobacco
  • Tolcapone
  • Topiramate
  • Tramadol
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Tretinoin, ATRA
  • Triamcinolone
  • Triazolam
  • Tricyclic antidepressants
  • Trimethobenzamide
  • Trimetrexate
  • Triprolidine
  • Ubrogepant
  • Ulipristal
  • Valbenazine
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vemurafenib
  • Verapamil
  • Vigabatrin
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Warfarin
  • Zaleplon
  • Zanubrutinib
  • Ziconotide
  • Zidovudine, ZDV
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zonisamide
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