Abacavir Lamivudine Zidovudine Brand Name
Trizivir
What is Abacavir Lamivudine Zidovudine
Abacavir Lamivudine Zidovudine is a combination of three nucleoside analog reverse transcriptase inhibitors (NRTIs), approved for the treatment of human immunodeficiency virus (HIV) infection.
Triple NRTI therapy is not considered highly active antiretroviral therapy (HAART). Use of a triple NRTI regimen was initially developed to preserve both protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) for later use.
However, study A5095 with the Adult AIDS Clinical Trials Group (ACTG) found that in antiretroviral treatment-naive patients, treatment with Trizivir alone was inferior to 2 other efavirenz containing treatment regimens (Trizivir plus efavirenz and Combivir (lamivudine, 3TC; zidovudine, ZDV combination tablet) plus efavirenz).
The recommendation for use of Trizivir in HIV infection was based on analysis of surrogate markers in controlled studies of abacavir in combination with lamivudine and zidovudine.
Trizivir received FDA approval in November 2000. In July 2006, a co-packaged product containing lamivudine; zidovudine tablets and abacavir tablets was approved by the FDA.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- alopecia
- anemia
- anorexia
- anxiety
- aplastic anemia
- arthralgia
- azotemia
- bone marrow suppression
- cardiomyopathy
- chills
- conjunctivitis
- depression
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- fever
- headache
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity
- hyperamylasemia
- hyperbilirubinemia
- hyperglycemia
- hypertriglyceridemia
- hypotension
- infection
- insomnia
- lactic acidosis
- lethargy
- lipodystrophy
- lymphadenopathy
- lymphopenia
- maculopapular rash
- malaise
- musculoskeletal pain
- myalgia
- myocardial infarction
- myopathy
- nausea
- neutropenia
- oral ulceration
- pancreatitis
- paresthesias
- peripheral neuropathy
- pharyngitis
- rash
- red cell aplasia
- renal failure (unspecified)
- respiratory arrest
- rhabdomyolysis
- seizures
- serious hypersensitivity reactions or anaphylaxis
- splenomegaly
- steatosis
- Stevens-Johnson syndrome
- stomatitis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vitamin B12 deficiency
- vomiting
- weakness
- wheezing
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- urinalysis
Contraindications
- abacavir hypersensitivity
- alcoholism
- anemia
- autoimmune disease
- bone marrow suppression
- breast-feeding
- cardiac disease
- children
- dental disease
- dental work
- females
- folate deficiency
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection resistance
- immune reconstitution syndrome
- in utero exposure
- infants
- myocardial infarction
- myopathy
- neonates
- neutropenia
- obesity
- peripheral neuropathy
- pregnancy
- radiation therapy
- renal failure
- renal impairment
- serious hypersensitivity reactions or anaphylaxis
- vitamin B12 deficiency
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Adefovir
- Alogliptin; Metformin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B lipid complex (ABLC)
- Atovaquone
- Atovaquone; Proguanil
- Azathioprine
- Benzhydrocodone; Acetaminophen
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bortezomib
- Cabozantinib
- Canagliflozin; Metformin
- Cidofovir
- Clarithromycin
- Clofarabine
- Colchicine; Probenecid
- Cyclophosphamide
- Dapagliflozin; Metformin
- Dapsone
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dofetilide
- Donepezil; Memantine
- Doxorubicin
- Doxorubicin Liposomal
- Echinacea
- Efavirenz; Emtricitabine; Tenofovir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Ertugliflozin; Metformin
- Ethanol
- Fluconazole
- Flucytosine
- food
- Foscarnet
- Fosphenytoin
- Ganciclovir
- Glipizide; Metformin
- Glyburide; Metformin
- Indinavir
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Interferon Gamma-1b
- Interferons
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Leflunomide
- Linagliptin; Metformin
- Lopinavir; Ritonavir
- Memantine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Nevirapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Orlistat
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Phenytoin
- Probenecid
- Procainamide
- Pyrimethamine
- Pyrimethamine; Sulfadoxine
- Ribavirin
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Sorbitol
- Stavudine, d4T
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonamides
- Telbivudine
- Teriflunomide
- Tipranavir
- Trimethoprim
- Trospium
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Voriconazole
