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Abacavir Lamivudine 3TC Brand Name
Epzicom
What is Abacavir Lamivudine 3TC
Abacavir Lamivudine 3TC is a combination of two nucleoside analog reverse transcriptase inhibitors (NRTIs) used for the treatment of human immunodeficiency virus (HIV) infection.
Double NRTI therapy is not considered highly active antiretroviral therapy (HAART); thus, it must be used in combination with other antiretroviral agents.
Epzicom received FDA-approval in August 2004; it was approved in pediatric patients weighing 25 kg or more in September 2015.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- alopecia
- anemia
- anxiety
- aplastic anemia
- chills
- conjunctivitis
- cough
- depression
- diarrhea
- dizziness
- dyspnea
- edema
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- fever
- gastritis
- headache
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity
- hyperglycemia
- hypertriglyceridemia
- hypotension
- insomnia
- lactic acidosis
- lethargy
- lipodystrophy
- lymphadenopathy
- lymphopenia
- maculopapular rash
- malaise
- migraine
- myocardial infarction
- nausea
- neutropenia
- oral ulceration
- pancreatitis
- paresthesias
- peripheral neuropathy
- pharyngitis
- pruritus
- rash
- renal failure (unspecified)
- respiratory arrest
- rhabdomyolysis
- seizures
- serious hypersensitivity reactions or anaphylaxis
- splenomegaly
- steatosis
- Stevens-Johnson syndrome
- stomatitis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vertigo
- vomiting
- weakness
- wheezing
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- urinalysis
Contraindications
- abacavir hypersensitivity
- alcoholism
- autoimmune disease
- breast-feeding
- cardiac disease
- children
- females
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection resistance
- immune reconstitution syndrome
- infants
- myocardial infarction
- neonates
- obesity
- peripheral neuropathy
- pregnancy
- renal failure
- renal impairment
- serious hypersensitivity reactions or anaphylaxis
Interactions
- Adefovir
- Alogliptin; Metformin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bortezomib
- Cabozantinib
- Canagliflozin; Metformin
- Dapagliflozin; Metformin
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dofetilide
- Donepezil; Memantine
- Echinacea
- Efavirenz; Emtricitabine; Tenofovir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Ertugliflozin; Metformin
- Ethanol
- food
- Glipizide; Metformin
- Glyburide; Metformin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Interferon Gamma-1b
- Interferons
- Linagliptin; Metformin
- Memantine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Orlistat
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Procainamide
- Ribavirin
- Sorbitol
- Tipranavir
- Trospium
