Abacavir Dolutegravir Lamivudine Brand Name
TRIUMEQ
What is Abacavir Dolutegravir Lamivudine
Abacavir; dolutegravir; lamivudine is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and pediatric patients weighing 40 kg or more.
This combination product consists of one integrase strand transfer inhibitor (INSTI) and two nucleoside analog reverse transcriptase inhibitors (NRTIs), and allows for once daily dosing using a single tablet.
The FDA approved package labeling contains the following Black Box warnings: fatal hypersensitivity reactions associated with abacavir, exacerbations of hepatitis B associated with discontinuation of lamivudine in patients co-infected with hepatitis B and HIV.
Indications & Dosage
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- alopecia
- angioedema
- anorexia
- anxiety
- aplastic anemia
- arthralgia
- conjunctivitis
- cough
- depression
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fatigue
- fever
- flatulence
- gastroesophageal reflux
- headache
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity
- hyperglycemia
- hypertriglyceridemia
- hypotension
- insomnia
- lactic acidosis
- lethargy
- lymphadenopathy
- lymphopenia
- maculopapular rash
- malaise
- myalgia
- myocardial infarction
- nausea
- neutropenia
- nightmares
- oral ulceration
- pancreatitis
- paresthesias
- peripheral neuropathy
- pharyngitis
- pruritus
- rash
- rhabdomyolysis
- seizures
- serious hypersensitivity reactions or anaphylaxis
- splenomegaly
- steatosis
- Stevens-Johnson syndrome
- stomatitis
- suicidal ideation
- teratogenesis
- toxic epidermal necrolysis
- urticaria
- vomiting
- weakness
- weight gain
- wheezing
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- urinalysis
Contraindications
- abacavir hypersensitivity
- alcoholism
- autoimmune disease
- Black patients
- breast-feeding
- cardiac disease
- contraception requirements
- depression
- females
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- Hispanic patients
- human immunodeficiency virus (HIV) infection resistance
- immune reconstitution syndrome
- myocardial infarction
- obesity
- peripheral neuropathy
- pregnancy
- pregnancy testing
- renal failure
- renal impairment
- reproductive risk
- serious hypersensitivity reactions or anaphylaxis
- serious rash
- suicidal ideation
Interactions
- Acalabrutinib
- Adefovir
- Alogliptin; Metformin
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bortezomib
- Bosentan
- Brigatinib
- Cabozantinib
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Canagliflozin; Metformin
- Capmatinib
- Carbamazepine
- Carvedilol
- Cenobamate
- Ceritinib
- Chromium
- Clobazam
- Cobicistat
- Conivaptan
- Daclatasvir
- Dapagliflozin; Metformin
- Darolutamide
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dofetilide
- Donepezil; Memantine
- Duvelisib
- Echinacea
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enzalutamide
- Ertugliflozin; Metformin
- Ethanol
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Etravirine
- Fedratinib
- Felbamate
- food
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Glipizide; Metformin
- Glyburide; Metformin
- Hetastarch; Dextrose; Electrolytes
- Idelalisib
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Interferon Gamma-1b
- Interferons
- Iron
- Iron Salts
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Letermovir
- Linagliptin; Metformin
- Lumacaftor; Ivacaftor
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salts
- Memantine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Mitotane
- Modafinil
- Nevirapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Orlistat
- Osimertinib
- Oxcarbazepine
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Polysaccharide-Iron Complex
- Primidone
- Procainamide
- Regorafenib
- Ribavirin
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Sapropterin
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sorafenib
- Sorbitol
- St. John’s Wort, Hypericum perforatum
- Sucralfate
- Tafamidis
- Tedizolid
- Telotristat Ethyl
- Temsirolimus
- Tipranavir
- Tolvaptan
- Topiramate
- Trospium
- Tucatinib
- Voriconazole
