Abacavir Dolutegravir Lamivudine

Abacavir Dolutegravir Lamivudine Brand Name

TRIUMEQ

What is Abacavir Dolutegravir Lamivudine

Abacavir; dolutegravir; lamivudine is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults and pediatric patients weighing 40 kg or more.

This combination product consists of one integrase strand transfer inhibitor (INSTI) and two nucleoside analog reverse transcriptase inhibitors (NRTIs), and allows for once daily dosing using a single tablet.

The FDA approved package labeling contains the following Black Box warnings: fatal hypersensitivity reactions associated with abacavir, exacerbations of hepatitis B associated with discontinuation of lamivudine in patients co-infected with hepatitis B and HIV.

Indications & Dosage

  • human immunodeficiency virus (HIV)
  • human immunodeficiency virus (HIV) infection

Side Effects

  1. abdominal pain
  2. alopecia
  3. angioedema
  4. anorexia
  5. anxiety
  6. aplastic anemia
  7. arthralgia
  8. conjunctivitis
  9. cough
  10. depression
  11. diarrhea
  12. dizziness
  13. dyspepsia
  14. dyspnea
  15. elevated hepatic enzymes
  16. eosinophilia
  17. erythema multiforme
  18. fatigue
  19. fever
  20. flatulence
  21. gastroesophageal reflux
  22. headache
  23. hepatic failure
  24. hepatitis B exacerbation
  25. hepatomegaly
  26. hepatotoxicity
  27. hyperglycemia
  28. hypertriglyceridemia
  29. hypotension
  30. insomnia
  31. lactic acidosis
  32. lethargy
  33. lymphadenopathy
  34. lymphopenia
  35. maculopapular rash
  36. malaise
  37. myalgia
  38. myocardial infarction
  39. nausea
  40. neutropenia
  41. nightmares
  42. oral ulceration
  43. pancreatitis
  44. paresthesias
  45. peripheral neuropathy
  46. pharyngitis
  47. pruritus
  48. rash
  49. rhabdomyolysis
  50. seizures
  51. serious hypersensitivity reactions or anaphylaxis
  52. splenomegaly
  53. steatosis
  54. Stevens-Johnson syndrome
  55. stomatitis
  56. suicidal ideation
  57. teratogenesis
  58. toxic epidermal necrolysis
  59. urticaria
  60. vomiting
  61. weakness
  62. weight gain
  63. wheezing

Monitoring Parameters

  • blood glucose
  • CBC with differential
  • CD4+ T cell count
  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • pregnancy testing
  • serum bilirubin (total and direct)
  • serum cholesterol
  • serum creatinine/BUN
  • serum lipid profile
  • urinalysis

Contraindications

  • abacavir hypersensitivity
  • alcoholism
  • autoimmune disease
  • Black patients
  • breast-feeding
  • cardiac disease
  • contraception requirements
  • depression
  • females
  • Graves’ disease
  • Guillain-Barre syndrome
  • hepatic disease
  • hepatitis B and HIV coinfection
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • hepatotoxicity or lactic acidosis
  • Hispanic patients
  • human immunodeficiency virus (HIV) infection resistance
  • immune reconstitution syndrome
  • myocardial infarction
  • obesity
  • peripheral neuropathy
  • pregnancy
  • pregnancy testing
  • renal failure
  • renal impairment
  • reproductive risk
  • serious hypersensitivity reactions or anaphylaxis
  • serious rash
  • suicidal ideation

Interactions

  • Acalabrutinib
  • Adefovir
  • Alogliptin; Metformin
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bortezomib
  • Bosentan
  • Brigatinib
  • Cabozantinib
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Canagliflozin; Metformin
  • Capmatinib
  • Carbamazepine
  • Carvedilol
  • Cenobamate
  • Ceritinib
  • Chromium
  • Clobazam
  • Cobicistat
  • Conivaptan
  • Daclatasvir
  • Dapagliflozin; Metformin
  • Darolutamide
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dofetilide
  • Donepezil; Memantine
  • Duvelisib
  • Echinacea
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enzalutamide
  • Ertugliflozin; Metformin
  • Ethanol
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Etravirine
  • Fedratinib
  • Felbamate
  • food
  • Fosamprenavir
  • Fosphenytoin
  • Fostamatinib
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Hetastarch; Dextrose; Electrolytes
  • Idelalisib
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Interferon Beta-1a
  • Interferon Beta-1b
  • Interferon Gamma-1b
  • Interferons
  • Iron
  • Iron Salts
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Letermovir
  • Linagliptin; Metformin
  • Lumacaftor; Ivacaftor
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Magnesium Salts
  • Memantine
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Mitotane
  • Modafinil
  • Nevirapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Orlistat
  • Osimertinib
  • Oxcarbazepine
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Peginterferon beta-1a
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Polysaccharide-Iron Complex
  • Primidone
  • Procainamide
  • Regorafenib
  • Ribavirin
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Sapropterin
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sorafenib
  • Sorbitol
  • St. John’s Wort, Hypericum perforatum
  • Sucralfate
  • Tafamidis
  • Tedizolid
  • Telotristat Ethyl
  • Temsirolimus
  • Tipranavir
  • Tolvaptan
  • Topiramate
  • Trospium
  • Tucatinib
  • Voriconazole
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