Acalabrutinib Brand Name – CALQUENCE What is Acalabrutinib Acalabrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved for the treatment of mantle cell lymphoma in adult patients who have received at least 1 prior therapy and as a single-agent or in combination with obinutuzumab in adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. …
AbobotulinumtoxinA Brand Name – Dysport What is AbobotulinumtoxinA AbobotulinumtoxinA is a botulinum toxin type A-hemagglutinin complex approved for the treatment of cervical dystonia and glabellar lines in adults, and for the treatment of spasticity in both pediatric and adult patients. Like other botulinum toxin type A formulations, abobotulinumtoxinA is an intramuscular toxin produced from fermentation …
Abiraterone Brand Names – Yonsa and ZYTIGA What is Abiraterone Abiraterone acetate inhibits 17 a-hydroxylase/C17,20-lyase (CYP17), which is an enzyme that is required for androgen biosynthesis and is expressed in testicular, adrenal, and prostatic tumor tissues. Abiraterone is used in combination with a corticosteroid for the treatment of metastatic castration-resistant prostate cancer (CRPC) either as …
Abemaciclib Brand Name – VERZENIO What is Abemaciclib Abemaciclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). It is approved in combination with fulvestrant for the treatment of women with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. Additionally, it is approved as monotherapy for women …
Abciximab Brand Name – ReoPro What is Abciximab Abciximab was the first FDA-approved platelet glycoprotein IIb/IIIa inhibitor. It is the Fab fragment of the chimeric monoclonal antibody 7E3. The substitution of human IgG for the murine IgG molecule produces a Fab fragment that causes fewer allergic and thrombocytopenic complications. Abciximab was FDA-approved in December 1994. …
Abatacept Brand Name Orencia What is Abatacept Abatacept is a fully human recombinant fusion protein categorized as a costimulatory or second-signal blocker of T cell activation. Abatacept disrupts the activation pathway of T cells causing a disturbance in key mechanisms of inflammation. Abatacept has been shown useful for a variety of inflammatory conditions, and is …
Abarelix Brand Name Plenaxis What is Abarelix NOTE: This drug is discontinued in the US. Abarelix is a synthetic antagonist of gonadotropin releasing-hormone (GnRH), which is also known as luteinizing hormone-releasing hormone (LHRH). Abarelix is the first FDA-approved sustained-release GnRH antagonist. Similar to GnRH agonists, abarelix inhibits the production of testosterone and estrogen. Indications endometriosis …