Abarelix Brand Name
Plenaxis
What is Abarelix
NOTE: This drug is discontinued in the US.
Abarelix is a synthetic antagonist of gonadotropin releasing-hormone (GnRH), which is also known as luteinizing hormone-releasing hormone (LHRH).
Abarelix is the first FDA-approved sustained-release GnRH antagonist. Similar to GnRH agonists, abarelix inhibits the production of testosterone and estrogen.
Indications
- endometriosis
- prostate cancer
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- anemia
- anorexia
- back pain
- constipation
- diaphoresis
- diarrhea
- dizziness
- dysuria
- elevated hepatic enzymes
- epistaxis
- erythema
- fatigue
- gynecomastia
- headache
- hot flashes
- hypertriglyceridemia
- hypotension
- impotence (erectile dysfunction)
- injection site reaction
- insomnia
- leukopenia
- libido decrease
- mastalgia
- nausea
- neutropenia
- osteopenia
- osteoporosis
- peripheral edema
- peripheral neuropathy
- pruritus
- QT prolongation
- rash
- syncope
- testicular atrophy
- thrombocytosis
- tinnitus
- urinary retention
- urticaria
- vomiting
- weakness
- weight loss
Monitoring Parameters
- prostate-specific antigen (PSA)
- serum testosterone concentrations
Contraindications
- alcoholism
- anticoagulant therapy
- breast-feeding
- children
- coagulopathy
- females
- Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
- hemophilia
- hepatic disease
- infants
- intravenous administration
- neonates
- obesity
- osteoporosis
- pituitary insufficiency
- pregnancy
- QT prolongation
- thrombocytopenia
- tobacco smoking
- vitamin K deficiency
Interactions
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Androgens
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Bepridil
- Beta-agonists
- Budesonide; Formoterol
- Cimetidine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Class IA Antiarrhythmics
- Clomipramine
- Clozapine
- Dasatinib
- Desipramine
- Dextromethorphan; Quinidine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Doxepin
- Droperidol
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enflurane
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Flecainide
- Fluconazole
- Fluoxetine; Olanzapine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol
- Formoterol; Mometasone
- Gemifloxacin
- Glycopyrrolate; Formoterol
- Halofantrine
- Haloperidol
- Halothane
- Ibutilide
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Isoflurane
- Ketoconazole
- Levalbuterol
- Levofloxacin
- Levomethadyl
- Maprotiline
- Mefloquine
- Metaproterenol
- Methadone
- Moxifloxacin
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Paliperidone
- Pentamidine
- Perphenazine; Amitriptyline
- Phenothiazines
- Pimozide
- Pirbuterol
- Procainamide
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Ranolazine
- Rilpivirine
- Risperidone
- Salmeterol
- Saquinavir
- Sevoflurane
- Sotalol
- Sparfloxacin
- Tacrolimus
- Telithromycin
- Terbutaline
- Tetrabenazine
- Tiotropium; Olodaterol
- Tricyclic antidepressants
- Trimipramine
- Umeclidinium; Vilanterol
- Vardenafil
- Vorinostat
- Ziprasidone
