Abarelix

Abarelix Brand Name

Plenaxis

What is Abarelix

NOTE: This drug is discontinued in the US.

Abarelix is a synthetic antagonist of gonadotropin releasing-hormone (GnRH), which is also known as luteinizing hormone-releasing hormone (LHRH).

Abarelix is the first FDA-approved sustained-release GnRH antagonist. Similar to GnRH agonists, abarelix inhibits the production of testosterone and estrogen. 

Indications

  • endometriosis
  • prostate cancer

Side Effects

  1. anaphylactic shock
  2. anaphylactoid reactions
  3. anemia
  4. anorexia
  5. back pain
  6. constipation
  7. diaphoresis
  8. diarrhea
  9. dizziness
  10. dysuria
  11. elevated hepatic enzymes
  12. epistaxis
  13. erythema
  14. fatigue
  15. gynecomastia
  16. headache
  17. hot flashes
  18. hypertriglyceridemia
  19. hypotension
  20. impotence (erectile dysfunction)
  21. injection site reaction
  22. insomnia
  23. leukopenia
  24. libido decrease
  25. mastalgia
  26. nausea
  27. neutropenia
  28. osteopenia
  29. osteoporosis
  30. peripheral edema
  31. peripheral neuropathy
  32. pruritus
  33. QT prolongation
  34. rash
  35. syncope
  36. testicular atrophy
  37. thrombocytosis
  38. tinnitus
  39. urinary retention
  40. urticaria
  41. vomiting
  42. weakness
  43. weight loss

Monitoring Parameters

  • prostate-specific antigen (PSA)
  • serum testosterone concentrations

Contraindications

  • alcoholism
  • anticoagulant therapy
  • breast-feeding
  • children
  • coagulopathy
  • females
  • Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
  • hemophilia
  • hepatic disease
  • infants
  • intravenous administration
  • neonates
  • obesity
  • osteoporosis
  • pituitary insufficiency
  • pregnancy
  • QT prolongation
  • thrombocytopenia
  • tobacco smoking
  • vitamin K deficiency

Interactions

  • Aclidinium; Formoterol
  • Albuterol
  • Albuterol; Ipratropium
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Androgens
  • Apomorphine
  • Arformoterol
  • Aripiprazole
  • Arsenic Trioxide
  • Bepridil
  • Beta-agonists
  • Budesonide; Formoterol
  • Cimetidine
  • Ciprofloxacin
  • Cisapride
  • Clarithromycin
  • Class IA Antiarrhythmics
  • Clomipramine
  • Clozapine
  • Dasatinib
  • Desipramine
  • Dextromethorphan; Quinidine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Doxepin
  • Droperidol
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enflurane
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Flecainide
  • Fluconazole
  • Fluoxetine; Olanzapine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Gemifloxacin
  • Glycopyrrolate; Formoterol
  • Halofantrine
  • Haloperidol
  • Halothane
  • Ibutilide
  • Imipramine
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Isoflurane
  • Ketoconazole
  • Levalbuterol
  • Levofloxacin
  • Levomethadyl
  • Maprotiline
  • Mefloquine
  • Metaproterenol
  • Methadone
  • Moxifloxacin
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olodaterol
  • Paliperidone
  • Pentamidine
  • Perphenazine; Amitriptyline
  • Phenothiazines
  • Pimozide
  • Pirbuterol
  • Procainamide
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Ranolazine
  • Rilpivirine
  • Risperidone
  • Salmeterol
  • Saquinavir
  • Sevoflurane
  • Sotalol
  • Sparfloxacin
  • Tacrolimus
  • Telithromycin
  • Terbutaline
  • Tetrabenazine
  • Tiotropium; Olodaterol
  • Tricyclic antidepressants
  • Trimipramine
  • Umeclidinium; Vilanterol
  • Vardenafil
  • Vorinostat
  • Ziprasidone
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