Risks of pregnancy in Sjogrens Syndrome

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What are the risks of pregnancy in Sjogrens Syndrome?

Pregnant women who are positive for anti-SSA and/or anti-SSB have an increased risk of delivering a fetus with neonatal lupus or congenital heart block due to transplacental passage of these antibodies.

This risk to the fetus is present regardless of whether the mother has SS, systemic lupus erythematosus, or is serologically positive for SS-A and/or SS-B but without clinical features of a rheumatic disease.

Antimalarial use in anti-SSA positive patients during pregnancy may decrease the risk of congenital heart block in the offspring

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