Arthritis of primary Sjogrens Syndrome
The distribution of arthritis in SS is similar to that of RA. Symmetric arthralgias and/or arthritis of the wrists, metacarpophalangeal, and proximal interphalangeal joints, frequently associated with morning stiffness and fatigue, is characteristic. In contrast to RA, Sjögren’s arthritis is nonerosive and tends to be mild. Anti-citrullinated protein antibodies may be seen in 8% to 10% of patients with primary SS and may predict a more severe phenotype or progression to RA.