triple negative breast cancer

What is a triple negative breast cancer, and what is its significance?

A breast cancer is termed triple-negative when it does not express receptors for estrogen, progesterone, and human epidermal growth factor receptor-2. Triple-negative cancers tend to be more aggressive, with a higher rate of recurrence than other subtypes. Studies have shown that triple-negative cancers also disproportionately affect premenopausal African American women and are more common in carriers of the BRCA1 mutation.

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