Most common histologic types of breast cancer

What are the most common histologic types of breast cancer?

The most common histologic types of breast cancer are invasive ductal carcinoma, intraductal (ductal carcinoma in situ [DCIS]) carcinoma, and invasive lobular carcinoma. Subtypes of invasive ductal carcinoma include medullary, mucinous, papillary, cribriform, metaplastic, micropapillary, and tubular. Less common histologic types of breast cancer include sarcoma and lymphoma. Metastasis to the breast is rare but may occur.

Inflammatory breast carcinoma is a rare, aggressive form of breast cancer that describes a clinical presentation of breast cancer rather than a histologic diagnosis, although most of these cancers are of ductal origin. Patients present with a red, warm, swollen breast with skin dimpling (peau d’orange) mimicking the skin of an orange. Inflammatory breast cancer represents less than 5% of breast cancers.

Paget disease of the breast is a rare form of breast cancer involving the areola. It is a clinical diagnosis where patients present with itching, scaling, and redness around the nipple area. Clinically, it may be confused with dermatitis or eczema. There may be associated DCIS or invasive carcinoma, along with the nipple changes.


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