What is the second most common primary bone tumor after multiple myeloma?
Osteosarcoma is the second most common primary bone tumor after multiple myeloma. About 75% of osteosarcoma lesions occur around the knee and typically arise in the metaphyseal region.
The peak incidence is in the second and third decades of life, and there is a smaller second peak in patients older than 50 years; this later peak has more pelvic and craniofacial involvement.
Osteosarcoma can develop after radiation exposure, with an average latent period of 11 years.