ANOTHER Syndrome

ANOTHER Syndrome

  • A rare, genetic, ectodermal dysplasia syndrome characterized by the association of hypohidrotic ectodermal dysplasia (manifesting with the triad of hypohidrosis, anodontia/hypodontia and hypotrichosis) with primary hypothyroidism and respiratory tract ciliary dyskinesia.
  • Patients frequently present urticaria pigmentosa-like skin pigmentation, increased mast cells and melanin depositions in the dermis and severe, recurrent chest infections.
  • There have been no further descriptions in the literature since 1986.


  • HEDH syndrome
  • Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome


How common is ANOTHER Syndrome

<1 / 1000000

Age of Onset



Autosomal recessive 

Symptoms of ANOTHER Syndrome

Very Common Symptoms

  • Alopecia 
  • Behavioral abnormality 
  • Ciliary dyskinesia
  • Delayed skeletal maturation
  • Dystrophic fingernails
  • Dystrophic toenail 
  • Fine hair
  • Hypohidrosis
  • Hypothyroidism
  • Recurrent respiratory infections
  • Short stature 
  • Sparse eyebrow 
  • Sparse scalp hair

Common Symptoms

  • Lacrimation abnormality
  • Melanocytic nevus 


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