ANOTHER Syndrome
- A rare, genetic, ectodermal dysplasia syndrome characterized by the association of hypohidrotic ectodermal dysplasia (manifesting with the triad of hypohidrosis, anodontia/hypodontia and hypotrichosis) with primary hypothyroidism and respiratory tract ciliary dyskinesia.
- Patients frequently present urticaria pigmentosa-like skin pigmentation, increased mast cells and melanin depositions in the dermis and severe, recurrent chest infections.
- There have been no further descriptions in the literature since 1986.
Synonyms
- HEDH syndrome
- Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome
Incidence
How common is ANOTHER Syndrome
<1 / 1000000
Age of Onset
Childhood
Inheritance
Autosomal recessive
Symptoms of ANOTHER Syndrome
Very Common Symptoms
- Alopecia
- Behavioral abnormality
- Ciliary dyskinesia
- Delayed skeletal maturation
- Dystrophic fingernails
- Dystrophic toenail
- Fine hair
- Hypohidrosis
- Hypothyroidism
- Recurrent respiratory infections
- Short stature
- Sparse eyebrow
- Sparse scalp hair
Common Symptoms
- Lacrimation abnormality
- Melanocytic nevus
