What is the major differential diagnosis of splenomegaly?
Major causes of splenomegaly include congestion (e.g., portal hypertension, splenic vein occlusion), malignancy (e.g., lymphoma, leukemia), hematologic disorders (e.g., thalassemia), myeloproliferative disorders (e.g., polycythemia vera, myelofibrosis), infectious and inflammatory disorders (e.g., Epstein-Barr virus infection, sarcoidosis, Felty’s syndrome), and storage disorders (e.g., Gaucher’s disease, amyloidosis).
