Important Nuances of Pain Modulation

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 Important Nuances of Pain Modulation

  • 1. Nociception without emotional or cognitive/interpretative correlation is not perceived as harmful, disagreeable, or unpleasant, so protective behavior is often nullified.
  • 2. C-fiber input drives the sensitization process and “wind-up” in the dorsal horn.
  • 3. Preemptive blockade of nerve impulses quells the neuronal processes that result in sensitization.

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