Important Nuances of Pain Modulation
- 1. Nociception without emotional or cognitive/interpretative correlation is not perceived as harmful, disagreeable, or unpleasant, so protective behavior is often nullified.
- 2. C-fiber input drives the sensitization process and “wind-up” in the dorsal horn.
- 3. Preemptive blockade of nerve impulses quells the neuronal processes that result in sensitization.