Immune mechanisms that can cause vasculitis

What are the immune mechanisms that can cause vasculitis?

Cell-mediated, immune complex-mediated, and antineutrophil cytoplasmic antibody (ANCA)-associated mechanisms are involved depending on the vasculitis. Examples of cell-mediated vasculitis include giant cell arteritis (GCA), Takayasu arteritis, and primary central nervous system (CNS) vasculitis. Examples of immune complex-mediated vasculitis include polyarteritis nodosa (PAN), Henoch–Schönlein purpura, cryoglobulinemic vasculitis, and cutaneous leukocytoclastic angiitis. The ANCA-associated vasculitides, which may involve both cellular and humoral mechanisms, include granulomatosis with polyangiitis (GPA; Wegener granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA; Churg–Strauss syndrome). The immune mechanisms of the other types of vasculitis are less certain.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856