Characteristic histologic features of vasculitis
- • Infiltration of the vessel wall by neutrophils, mononuclear cells, and/or giant cells.
- • Fibrinoid necrosis (panmural destruction of the vessel wall
- Leukocytoclasis (dissolution of leukocytes, yielding “nuclear dust”).
Perivascular infiltration is a nonspecific histologic finding observed in a variety of disease processes and is not considered diagnostic of vasculitis even though it may coexist in vasculitic tissues.
